Halogenated Compounds

Stability Hygroscopic Applications Labelled analogue of Chlorocholine Chloride, a plant growth regulator that is primarily used on ornamental plants. References Pinto, A.C.R. et al.: Acta Horticult., 683, 399 (2005); Gu, Z. et al.: Hun. Nong. Dax. Xueb., 35, 383 (2009); Xing, S. et al.: J. Med. pLant Res., 5, 1962 (2011);

Applications 3-Chloro-N-methylpropan-1-amine Hydrochloride can be used as reactant/reagent in oxidative metabolism of ferrocene analogs of tamoxifen: characterization and antiproliferative activities of metabolites. References Richard, M. A., et al.: ChemMedChem, 10, 981-990 (2015)

Applications N1-(3-Aminopropyl)-N1-(2-bromoethyl)propane-1,3-diamine is a useful research chemical.

Applications (3R)-3-Fluoropyrrolidine-1-sulfonyl Chloride is used as a reagent in the preparation of heterocyclic compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides. References Crew, A. P., et al.: PCT Int. Appl. 1014pp. (2018)

Applications p-Chloroaniline-d4 Deuterium Chloride is an intermediate in synthesizing N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide-d4 (C377537), an isotope labelled analog of N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide. N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide is an impurity of Chlorhexidine Digluconate (C292770). Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouth rinses. References Addy, M. & Wright, R.: J. Clin. Periodont., 5, 198 (1978); Kuruvilla, J. & Kamath, M.: J. Endododont., 24, 472 (1998); Maki, D., et al.: Lancet, 338, 339 (1991); Popovich, K., et al.: Inf. Cont. Hosp. Epidem., 30, 959 (2009); Rosenberg, A., et al.: Surg. Gyn. Obst., 143, 789 (1976)

Applications 4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity. References Singh, S. et al.: Eur. J. Pharm. Sci., 25, 255 (2005); Tewari, A. et al.: Indian. J. Chem. B., 41B, 664 (2002);

Applications 2-iodo-4-methylphenol is a useful research chemical for organic synthesis and other chemical processes. References Liu, Y., et al.: RSC Advances, 8, 28637 (2018); Xu, S., et al.: Mol. Catal., 452, 264 (2018); Alonso-Maranon, L., et al.: J. Org. Chem., 83, 7970 (2018)

Applications 6-Fluoro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful research chemical.

Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow. References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)