Nitro

N-(4-Nitrophenyl)-3-oxobutyramide is a drug candidate for the treatment of tuberculosis. It has been shown to have antitubercular activity in vitro. In this study, N-(4-nitrophenyl)-3-oxobutyramide was synthesized and screened for antitubercular activity using an enzyme linked immunosorbent assay (ELISA) technique. The molecular weight of this compound is 215.2 g/mol and its elemental analysis showed that it consists of carbon, hydrogen, nitrogen and oxygen. The chemical structure of N-(4-nitrophenyl)-3-oxobutyramide is a carboxamide moiety with two imidazole substituents on either side. This compound can also be classified as a dicyclohexyl proton because it contains a carbonyl group (-C=O) attached to a ring system containing two other rings which are both five members in size (

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4-Methylphenylnitropropene is a psychostimulant drug that has been shown to have a high binding affinity for dopamine transporters. It is also known to increase the level of dopamine in the synaptic cleft and can be used as a research tool for understanding the function of dopamine in neuronal synapses. 4-Methylphenylnitropropene has been shown to cause an increase in locomotor activity and is able to induce euphoria when administered to rats. This drug is not thought to cause any physical dependence, although it may lead to psychological dependence.

Bis-(4-nitrophenyl)amine (NPPA) is a primary amine that is used as a precursor in the production of dyes, plastics, and pesticides. It can be synthesized by the reaction of nitric acid with aniline. NPPA exists in two forms: uncomplexed and complexed. The uncomplexed form is a white solid at room temperature and soluble in organic solvents such as dimethylformamide. The complexed form has a particle size of less than 0.2 micrometers and is insoluble in organic solvents. When heated to temperatures below its melting point, NPPA decomposes into nitric oxide, nitrogen dioxide, and water vapor. In an acidic environment, NPPA undergoes bond cleavage to produce cyanate ions.

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1,3-Dichloro-2-methyl-5-nitrobenzene is a chiral reagent used for the preparation of α-chloroamino acids. It is prepared by chlorinating 1,3-dichlorobenzene with a mixture of chlorine and methyl chloride in the presence of an acidic catalyst. This reaction yields a mixture of 2,4-dichlorobenzoic acid and 1,3-dichloro-2,5-dimethylaniline. The methyl group can be removed by catalyzed hydrogenation to give 1,3-dichloro-2-methylbenzene. The compound crystallizes from ether in needles that melt at 110°C and boils at 190°C.

3-Methyl-4-nitrobenzeneamine is a chemical compound that can be used as a reagent in the identification of proteins and peptides. It reacts with sulfonic acids to form 3-methyl-4-nitrobenzenesulfonic acid, which can be identified using chromatography. The 3-methyl group on the nitrobenzeneamine is an orthophosphate mimic that facilitates the formation of an insoluble salt with bovine serum albumin. This reaction is shown by the change in morphology from crystallised to amorphous and by increased turbidity due to precipitation of the protein. 3-Methyl-4-nitrobenzeneamine has been synthesised for use in molecular response studies and can be oriented for peptide mass fingerprinting. This chemical compound reacts with amines, such as tryptic, producing nitrosamines.

2-Bromo-6-methyl-4-nitroaniline is a fine chemical that is used in the preparation of other chemicals and as a reagent. It can be used as an intermediate for organic synthesis, such as the conversion of 2-bromoindole to indoxyl, or as a building block for the preparation of more complex compounds. This chemical is also versatile in that it can be used in reactions with different reactants, including amines, carboxylic acids, thiols, and alcohols.

1-N-Acetyl-3-nitro-p-phenylenediamine is a hydrolytic product of 1,4-diaminobenzene. It is an intermediate in the preparation of naphthalene diamine and has been shown to hydrolyze in acidic solutions.

4-Nitro-3-iodoanisole is a bauerine that is used as a ligand in asymmetric catalysis. It is an atropisomeric compound, meaning it can exist in two different forms. The two forms of 4-nitro-3-iodoanisole are identical except for the orientation of the axial ligands on opposite sides of the molecule. The axial ligands on one form are biphenyl and nitrous oxide, while the axial ligands on the other form are nitrous oxide and biphenyl. 4-Nitro-3-iodoanisole has been used to catalyze reactions such as alkylation and coupling reactions with a variety of substrates, including β-carbolines, phenols, and amines.

2-Amino-4-methyl-5-nitropyridine is a chemical compound with the molecular formula C6H8N6. It is a white solid that can be used as a precursor to a variety of other compounds. This compound has been used for the synthesis of 2,5-dihydroxybenzoic acid and protonated 2,5-dihydroxybenzoic acid. The acidity of this compound is dependent on pH, with an acidic pH resulting in protonation of the amine group. 2Amino-4-methyl-5-nitropyridine is used as a precursor for many other chemicals, including 2,5-dihydroxybenzoic acid and protonated versions of this molecule. The compound's acidity depends on pH; at acidic pH levels it will be protonated.

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3,4-(Methylenedioxy)-6-nitrocinnamic acid is a cytotoxic molecule that inhibits the growth of cells by interfering with the synthesis of proteins. It binds to DNA and prevents the transcription process from occurring. This molecule has been shown to inhibit endoplasmic reticulum and Golgi apparatus functions in plant cells. 3,4-(Methylenedioxy)-6-nitrocinnamic acid has also been used as a polymerization agent for polyacrylamide gels. A number of modifications have been made to this molecule in order to increase its effectiveness, such as methyl esterification and mutagenesis. This compound has also been shown to enhance Taxol's anti-cancer effects on cell cultures.

3-Nitrosopyridine-2,6-diamine is a fluorometric assay for the detection of nitrite in urine. The reaction mechanism is based on the reaction of 3-nitrosopyridine-2,6-diamine with nitrite to form a fluorescent product that can be measured using a fluorometer. This assay is sensitive and selective, and has been used to measure nitrite levels in biological fluids such as urine and saliva. 3-Nitrosopyridine-2,6-diamine was first described by German chemist Fritz Haber in 1907. In this experiment, Haber reacted the chemical with potassium hydroxide (KOH) to produce an acid solution that contains nitrite ions. When mixed with water containing an indicator dye such as phenolphthalein or methyl red, it produces a pink color that can be quantified using the fluorescence technique.

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4-(2-Nitrovinyl)phenol is a monoclinic crystalline solid that belongs to the group of nitrophenols. It has been shown to form nanoparticles with diameters between 10 and 100 nm, which are suitable for surface functionalization. 4-(2-Nitrovinyl)phenol has been used as a catalyst for the production of biosensors, highlighting its potential in biomedicine and advancements in nanotechnology research. This compound has also been used for surface functionalization, and it is currently being studied for use as a catalyst in the development of biosensors.

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(1-(4-Diethylamino)phenyl)-2-nitroethene is a fluorescent probe that can be used to measure the growth rate of microorganisms. It is also a polarizable fluorescent molecule that is sensitive to environmental effects such as pH, temperature, and light intensity. This compound has been used as a chromophore in optical devices and has been observed to have linear responses to changes in time constants. The fluorescence of (1-(4-diethylamino)phenyl)-2-nitroethene is proportional to the molecular response of the protein or nucleic acid it binds to. This compound is also an inorganic compound with dipole moments, which are properties that allow it to interact with other compounds.

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4-Nitrobenzenediazonium Hexafluorophosphate is a diazonium salt that can be used as a reagent for the conversion of alcohols to nitriles. It can also be used in the synthesis of organic compounds and pharmaceuticals. 4-Nitrobenzenediazonium Hexafluorophosphate is soluble in methanol and other polar solvents, but insoluble in water. Its elemental composition is C6H5N2O2F6P. The chemical's IR spectrum shows a strong absorption band at 1640 cm-1. A series of NMR spectra show two signals at 8.8 ppm and 8.0 ppm, respectively, corresponding to the protons on the aromatic ring and the nitro group, respectively. This compound has been shown to undergo electrochemical transfer reactions with electron acceptors such as tetrafluoroborates (BF4).

2-Cholro-5-nitrothiazole is an effervescent pharmaceutical preparation with antifungal, antiprotozoal, and antibacterial properties. It has been used to treat vaginal infections caused by Trichomonas vaginalis. 2-Cholro-5-nitrothiazole is an active form of the drug thiocarbamate, which inhibits the synthesis of fatty acids in microorganisms. This drug also inhibits the growth of bacteria that are resistant to nitrothiazole and formamide, such as methylacetamido and metal ion. The coordination chemistry of this compound is oleaginous and fatty acid.

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Ethyl 7-nitroindole-2-carboxylate is a supramolecular molecule that has two binding sites: one for the pyrrole and one for the nitro group. It can be dimerised to form a dimer. The molecule has a x-ray crystal structure, which shows that it interacts with itself in the crystal lattice. This structure also reveals that the molecule exists as monomers in solution. Supramolecular chemistry involves the interaction of molecules on an atomic or molecular level, leading to self-assembly and formation of functional materials with unique properties.

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4-[1-(4-Iodophenyl)-5-(4-nitrophenyl)-formaz-3-yl]-1,3-benzene disulfonate, disodium salt (WST) is a cell proliferation assay that uses formazan to measure the activity of cytosolic enzyme NADH:oxidoreductase (NADH:oxygen oxidoreductase). WST is used to assess the cytotoxicity of compounds in vitro and can be used to validate the cytotoxicity of compounds. The assay quantifies cellular metabolism by measuring the conversion of NADH into formazan. The monosodium salt, formazan product is measured by measuring absorbance at 450 nm. The disodium salt, formazan product is measured by using a uv detector set at 254 nm. Acetonitrile and chromatography are used for purification and validation steps.

4-Nitro-2-(1,1,2,2-Tetrafluoroethyl)-6-(Trifluoromethyl)-1H-Benzimidazole is a novel fluorinated benzimidazole that has been shown to have immune modulating properties. It can induce the production of proinflammatory cytokines and chemokines in vitro by stimulating the immune system. 4-Nitro-2-(1,1,2,2-Tetrafluoroethyl)-6-(Trifluoromethyl)-1H-Benzimidazole also induces DNA repair and can protect against oxidative damage. This drug has been shown to be non-toxic to rats and mice at doses up to 2 g/kg body weight.

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5-Nitro-2-aminophenol is an aminophenol that has been shown to be a carcinogen in animal studies. It can cause allergic reactions and has been shown to have oxidative DNA damage, which can lead to cancer. 5-Nitro-2-aminophenol is used as a chemical intermediate in the preparation of other chemicals and pharmaceuticals. This chemical has been studied extensively for its analytical properties and is used as a reagent in chromatography. The coordination geometry of 5-nitro-2-aminophenol is octahedral, with nitro groups occupying one axial site each. The toxicity of this compound in animals has been studied extensively, including carcinogenic potential and mutagenicity studies, and it has been shown to inhibit the growth of cultured cells at high concentrations.

The active ingredient of Speciosa is the (5E)-2-mercapto-5-(4-nitrobenzylidene)-1,3-thiazol-4(5H)-one, which has been shown to have anti-aging effects. This compound is found in kidney beans and has been recrystallized and activated before use. It also contains speciosa, a mixture of alkaloids that includes indoles, such as tryptamine and 5-methoxyindole. The alcohol extract of Speciosa contains impurities and organic solvents. The complex enzyme system in this plant extract breaks down carbohydrates into sugars that are then absorbed by the body. The residue left over after extraction is rich in hyperglycemia.

5-Fluoro-2-nitrobenzoic acid is a phosphotungstic acid and an anti-inflammatory agent. It has been shown to exhibit apoptotic activity in vitro, which may be due to its ability to induce the release of cytochrome c from mitochondria. 5-Fluoro-2-nitrobenzoic acid has also been shown to inhibit the production of inflammatory cytokines such as tumor necrosis factor alpha (TNFα), interleukin 1β (IL1β) and IL6 in vitro. Its pharmacokinetic properties have been studied in rats and mice, with an oral bioavailability of 100%. The drug has also been shown to cross the blood brain barrier, with a high degree of uptake into the brain tissue.

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Applications trans-β-Nitrostyrene, and its derivatives such as 3,4-methylenedioxy-β-nitrostyrene (MNS) and 4-O-benzoyl-3-methoxy-β-nitrostyrene (BMNS), has shown to exhibit potent anti-platelet activities and cytotoxicity. References Hsieh, P. W., et al.: Bioorg. Med. Chem., 18(21), 7621 (2010);

1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) can be used as a source of diazomethane on very small scales. An initial rearrangement of MNNG occurs as the N-nitrosyl oxygen cleaves the guanidine group, subsequent deprotonation of the methyl group with aqueous base results in the formation of diazomethane and N-nitrourea. The advantages of MNNG are that it is an easily handled solid with a long shelf life, however it is a potential carcinogen and a skin sensitiser. MNNG also finds application as a DNA alkylating agent used to probe DNA base damage repair mechanisms.

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Applications Methyl 2-fluoro-3-nitrobenzoate

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Isonitrosoacetophenone is a plant metabolite that has been found in the leaves of some plants. It is a chlorogenic acid that is a redox potential, which means it can either act as an electron donor or electron acceptor. Isonitrosoacetophenone has been shown to have neurologic effects in rats and mice, with symptoms including head nodding, circling, and muscle tremor. These effects were observed after intraperitoneal injections of the compound. The mechanism of action for these neurotoxic effects may be due to inhibition of protein synthesis and oxidative stress. Isonitrosoacetophenone has also been found to inhibit the activity of p-nitrophenyl phosphate (PNPP) reductase in rat liver homogenates with an IC50 value of 1 μM. This effect was found to be reversible by addition of NADPH and GSH, suggesting that this compound may cause oxidative stress through depletion of glutathione

4-Chloro-7-methoxy-6-nitroquinazoline is an inhibitor of protein kinases and growth factors. It has been shown to have inhibitory activities against tyrosine phosphorylation, which may be due to its ability to bind to the ATP binding site of the enzyme. 4-Chloro-7-methoxy-6-nitroquinazoline also has inhibitory effects on cellular proliferation in a variety of cancer cell lines, including melanoma, prostate cancer, breast cancer, and pancreatic cancer. This drug has also been shown to induce regression in mouse xenografts and rat tumors.

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1,1,2-Trifluorotrinitroethane (TFE) is a fluorinated nitroalkane that can be synthesized by the reaction of dipotassium difluoroacetylnitrate and trinitrofluoroethane. The chemical name for TFE is 1,1,2-trifluoro-2-(trinitromethyl)-1,2-dihydroethane. TFES is a solid at room temperature. The synthesis of TFES involves two steps: first the reaction of dipotassium difluoroacetylnitrate with trinitrofluoroethane to produce 2-diazo-1,3,3-trimethylcyclobutane; then the reaction of 2-diazo-1,3,3-trimethylcyclobutane with potassium fluoride to produce TFES.

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2-(Acetylamino)-5-nitrobenzoic acid is a carboxylic acid with a molecular weight of 194.2. It has an acidic profile and a nucleophilic carboxylate group that can form hydrogen bonds with water molecules. 2-(Acetylamino)-5-nitrobenzoic acid will react with electrophilic nitro groups in the presence of buffers to produce a stable molecule, which is a buffer itself. This reaction will also produce an amide group, which stabilizes the molecule by intramolecular hydrogen bonding. The 2-(acetylamino)-5-nitrobenzoic acid can be used as a buffer or as an intermediate in other reactions involving nucleophilic and electrophilic groups.

5-Nitro-1,2,3-benzenetricarboxylic acid is a coordination compound that has been used as a luminescent probe for the detection of anions. This compound is an ancillary ligand with a carboxylate group. It has been shown to inhibit leukemia cells by hydrogen bonding interactions and to have a structural analysis technique. 5-Nitro-1,2,3-benzenetricarboxylic acid has also been shown to have an inhibitory effect on structural analysis and supramolecular studies.

4-Nitroquinoline-N-oxide is a polymerase chain reaction (PCR) inhibitor that blocks the activity of methyltransferases, which are enzymes involved in DNA replication and repair. The mechanism of action has been shown to be due to the inhibition of the activities of these enzymes in cancer tissues. The efficacy of 4-Nitroquinoline-N-oxide has been demonstrated using an experimental model system composed of cells from Candida glabrata and other cancers, as well as a model system for carcinogenesis in vitro. This compound also shows antiinflammatory activity and can be used as a natural compound for chemotherapy. Chromatographic analysis has revealed that 4-Nitroquinoline-N-oxide is not toxic to wild type strains, but it is toxic to cancer cells with mutations in their DNA repair mechanisms.

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2-Cyclohexyl-4,6-dinitrophenol is a chemical that inhibits the synthesis of viral DNA. It has been shown to have minimal toxicity in animal models and may be used for the treatment of metabolic disorders, such as hepatic steatosis or hepatitis. 2-Cyclohexyl-4,6-dinitrophenol has also been shown to inhibit the toll-like receptor (TLR) pathway and induce an antiviral state in vitro. In addition, it was found to have an effect on mitochondrial membrane potential, which may explain its antiviral activity. 2-Cyclohexyl-4,6-dinitrophenol has also been shown to inhibit viral replication in cells infected with HIV and other viruses such as Hepatitis C virus.

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Methyl 3,5-dinitrosalicylate is an efficient method for glycosylation of oligosaccharides. It is a stereoselective reaction that occurs in the presence of carbon disulphide as a solvent and topoisomerase as a catalyst. The reaction proceeds by nucleophilic attack of the glycosyl donor on the electrophilic nitro group of methyl 3,5-dinitrosalicylate to form a glycosyl-enzyme intermediate. This intermediate is then hydrolyzed to release an enzyme-bound sugar product. The reaction proceeds efficiently at room temperature and can be used in solid phase synthesis.