Nitro

4-Fluoro-7-nitrobenzofurazan (4FNBF) is a fluorescent derivative of the amino acid GABA, which is a neurotransmitter. 4FNBF has been used as a potential biomarker to detect the presence of gamma-aminobutyric acid in human serum and as an analytical reagent for the detection of lysophosphatidic acid (LPA). The fluorescence intensity of 4FNBF increases when it binds to LPA, and this can be detected using a photomultiplier tube. A sample preparation method involving liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has also been reported for the analysis of fatty acids in biological samples. This compound has been shown to have antimicrobial properties against Gram-positive bacteria such as Staphylococcus aureus and Gram-negative bacteria such as Escherichia coli.

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6-Methoxy-8-nitroquinoline is a nitroquinoline derivative that inhibits the growth of malaria parasites in vitro. It has been shown to inhibit the polymerase activity of malarial DNA polymerase in mammalian cells. 6-Methoxy-8-nitroquinoline has also been shown to be an effective antimalarial agent, but is not active against chloroquine or pyrimethamine resistant strains of Plasmodium falciparum. It binds to calcium in the parasite's acidic environment, which prevents it from dissolving and thereby inhibits its activity. This drug also has an effect on human erythrocytes and can be used as a treatment for malaria.

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N-Nitrosobis(2-hydroxypropyl)amine is a polymerase chain reaction (PCR) enhancer that has been shown to be carcinogenic in experimental animals. It is used as a synthetic retinoid, which results in the conversion of thyroxine to triiodothyronine by the thyroid gland. N-Nitrosobis(2-hydroxypropyl)amine is also used as an experimental model for squamous cell carcinoma and tumors. It causes tumor development by inhibiting DNA synthesis and increasing cellular proliferation, which leads to liver lesions and carcinomas in animal models.

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5-Bromo-2-methoxy-3-nitropyridine is a potent inhibitor of phosphoinositide 3-kinase (PI3K) that has tumor growth inhibition activity. It is also an inhibitor of cellular activities, such as cell proliferation and cell migration. 5-Bromo-2-methoxy-3-nitropyridine inhibits the activation of mammalian PI3K, which is necessary for the production of phosphatidylinositol phosphate (PIP) in cells. This drug also exhibits anti-tumor activity in hepatocellular carcinoma and other cancers with PI3K activation. 5Bromo2 methoxy 3 nitropyridine binds to the active site of mammalian PI3K and blocks the production of PIP, leading to tumor growth inhibition.

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1,3-Diiodo-2-methoxy-5-nitrobenzene is an acetyl derivative of a nitrobenzene. It has been shown to have a hydrogen bond with the acetyl group, as well as interactions with other substances. The structural parameters and interactions of this molecule have been analyzed using X-ray crystallography. The supramolecular arrangement of 1,3-diiodo-2-methoxy-5-nitrobenzene can be described by the following parameters: hydrogen bonds, steric effects, and ionic interactions.