Nitro

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5-Nitro-1H-imidazole-4-carboxylic acid is a hydrophobic natural product that can be used in cancer therapy. It has been shown to inhibit the growth of tumor cells and induce apoptosis. This compound is also active against leukemia, ovarian cancer, and breast cancer cell lines. 5NICA inhibits protein synthesis by blocking purine uptake and inhibiting the enzyme ribonucleotide reductase, which converts ribose into deoxyribose nucleotides. This inhibition leads to the depletion of ATP and an increase in reactive oxygen species (ROS) levels, which ultimately leads to apoptosis. 5NICA has been shown to bind strongly to the active site of ribonucleotide reductase with high affinity, thereby preventing substrate binding and catalysis.

L-Leucine 4-nitrophenyl ester hydrochloride is a reaction component, reagent, and useful scaffold that is used in the synthesis of complex compounds. It is a versatile building block and useful intermediate that can be used to synthesize fine chemicals such as pharmaceuticals, agrochemicals, or dyes. L-Leucine 4-nitrophenyl ester hydrochloride has CAS number 75691-76-8.

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4-Nitrobenzonitrile is an organic compound that has been identified as a potential precursor to the explosive RDX. It can be synthesized by nitration of benzene with nitric acid, followed by reduction of the nitro group with hydrogen chloride. 4-Nitrobenzonitrile is soluble in organic solvents such as ethers and chloroform. It has three functional groups: aryl halide, nitro, and ester. It is a colorless solid that has a boiling point of 204 °C. IR spectra show that it has four absorption bands at 1710 cm−1, 1595 cm−1, 1225 cm−1, and 1085 cm−1. The chemical shifts for these bands are indicative of the presence of electron-withdrawing substituents on the aromatic ring (e.g., chlorine). Nitrogen NMR spectra show signals at δ 2.5 ppm and δ 3.

(4-Nitrophenyl)methanesulfonylchloride is an inhibitor of the enzyme nitrate reductase, which is found in many bacteria. It also inhibits chloride ion uptake by gram-negative bacteria. (4-Nitrophenyl)methanesulfonylchloride is used as a carbonic anhydrase inhibitor and for the treatment of epilepsy. This drug has been shown to inhibit the growth of gram-positive bacteria such as Staphylococcus aureus and Escherichia coli, but not against gram-negative bacteria such as Pseudomonas aeruginosa or Acinetobacter baumannii. The drug has been shown to have antibacterial effects against these gram-negative bacteria in vitro, but studies in vivo have been inconclusive.

3-Amino-2-nitropyridine is a heterocyclic compound that is an oxidation product of 2,4,6-trinitrotoluene. 3-Amino-2-nitropyridine is a potent inhibitor of the d4 receptor and has been shown to be active in animal models of cancer and autoimmune diseases. The mechanism of action of this drug is not well understood, but it has been found to inhibit cell proliferation in vitro by binding to nucleophilic sites on the receptor. Nitrobenzoic acid may also contribute to its activity. 3-Amino-2-nitropyridine inhibits inflammatory responses by inhibiting cell proliferation and migration.

Applications N-Nitrosodipropylamine is a a N-nitrosamine derivative. The mutagenic activities of the carcinogenic N-nitrosamines were studied on both S. typhimurium TA100 and TA98, revealing moslty mutagenic activities on TA100 with few exceptions on TA98 (1). Water contaminant (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Yahagi, T. et al.: Mutat. Res. Fund. Mol. Mech. Mut. 1977. Apr:48(2) p121-1292. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20