Ketones

Intermediate in the synthesis of empagliflozin

1-(2-Fluorobenzyl)-1H-indole-2,3-dione (1) is a new antibacterial agent that has been shown to have affinity for the cell wall of Staphylococcus aureus. It also has anti-cancer activity and is capable of catalysis in an active site. 1-(2-Fluorobenzyl)-1H-indole-2,3-dione can be modified by thiosemicarbazide and 4-hydroxycoumarin to form derivatives with increased antibacterial activity against faecalis and methicillin resistant enterobacter. The analytical method used to measure the antimycobacterial activity of 1-(2-fluorobenzyl)-1H-indole-2,3-dione is hydrogen bond titration.

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2-Hexanone is a ketone that is used as a solvent in chemical analysis. It is also used for the treatment of wastewater and for sample preparation in tissue culture. 2-Hexanone has been shown to increase the activity of complex enzymes such as cytochrome P450, which metabolize drugs and other xenobiotics. 2-Hexanone has also been shown to enhance the metabolism of methyl n-butyl ketone and locomotor activity in CD-1 mice. This compound has been shown to have water vapor permeability properties, which may be due to its hydroxyl group. The metabolic products of 2-hexanone include trifluoroacetic acid, which can lead to kidney damage when consumed orally or inhaled.

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2,6-Dimethyl-4-heptanone (DMH) is a ketone that can be used as a substrate for the production of films. DMH is also a good candidate for use in the manufacture of water-vapor sensors because it has been shown to produce low levels of water vapor. The reaction mechanism of DMH has been studied using mass spectroscopy and found to involve zirconium oxide and sodium carbonate. DMH has been shown to be an effective reagent for the extraction of hydroxyl groups from human serum proteins. It also reacts with picolinic acid, which is found in plant cell walls, to form metal chelates.