Amides

Intermediate in the synthesis of vildagliptin

Cefpiramide is a sulfonamide antibiotic that belongs to the group of cephalosporin antibiotics. It is an experimental drug which has been shown in vitro to be soluble in human serum and tissue. Cefpiramide inhibits bacterial growth by binding to the 50S ribosomal subunit, similar to other cephalosporins. The drug has been shown to have antimicrobial properties against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens. Cefpiramide has also demonstrated activity against Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae. This drug is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

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4-Amino-N-(3-methoxyphenyl)benzenesulfonamide is a molecule that has been proposed as a possible acceptor for organic photovoltaic cells. It has been shown to be a good electron donor, and it has the ability to form dimers with other molecules. The FTIR spectrum of 4-amino-N-(3-methoxyphenyl)benzenesulfonamide shows peaks at 1728 cm−1, 1678 cm−1, and 1269 cm−1. The first peak corresponds to the stretching vibration of the C=O group in an ester bond. This peak is shifted upfield when compared to those of other sulfonamides due to the electron withdrawing methoxy group on the phenyl ring. The second peak corresponds to the stretching vibration of the C=C bonds in the benzene ring. The third peak corresponds to the bending vibration of NH2 groups in am

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Dimethylisobutyramide is a functional molecule that belongs to the group of amides. It has been shown to be active in multigrams, and can be used for the synthesis of other bioactive molecules. Dimethylisobutyramide is synthesized from an organic solvent such as tetramethylurea and dimethylamine. The reaction is catalyzed by a metal ion such as palladium, nickel or copper and a halogen such as chlorine, bromine or iodine. The reaction is performed in an inert atmosphere such as nitrogen or argon with triphosgene or phosphorus oxychloride as the oxidizing agent.

Carboxyphosphamide is a cytotoxic drug that belongs to the class of nitrogen mustards. It is used as an antineoplastic agent in the treatment of cancer. Carboxyphosphamide has been shown to inhibit DNA synthesis and protein synthesis, which are vital for cell division. The stability of this drug is due to its chemical structure, which prevents it from undergoing hydrolysis by esterases or glucuronidases. Carboxyphosphamide has been shown to be effective against autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This drug also inhibits the production of enzymes such as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX).

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