Amides

2-Phenylbenzamide (2PB) is a drug that belongs to the class of anthelmintics. It binds to the nicotinic acetylcholine receptor and inhibits the release of acetylcholine at neuromuscular junctions, leading to paralysis and death of the parasite. 2PB also has been shown to have anti-inflammatory properties in mice with colitis, which may be due to its ability to inhibit prostaglandin synthesis. The molecular docking analysis showed that 2PB binds covalently with nitro-containing molecules, such as nitrosamines, which are found in cigarette smoke and are known carcinogens. This binding may contribute to the development of cancer through inhibition of DNA repair mechanisms.

1H-Imidazole-2-carboxamide is a purine derivative that can inhibit the activity of certain molecules. It has been shown to have an inhibitory effect on the metabolism of fatty acids and metabolism disorders, as well as the physiological effects of insulin resistance. The molecule also inhibits uptake and cross-linking in cells, which may be useful in treating cancer or other metabolic disorders.