Aldehydes

4-Chloro-2-fluorobenzaldehyde is an aryl aldehyde that belongs to the class of chemical compounds known as chloroaldehydes. It can be synthesized from 4-chlorophenylacetic acid and 2,3-dichloroacetone. The compound is chiral and has two enantiomers. One enantiomer is less reactive than the other, which is more reactive. 4-Chloro-2-fluorobenzaldehyde can be used in the synthesis of a variety of organic compounds, such as pharmaceuticals, herbicides, pesticides, and dyes. This compound can also be used for microbial strain identification by liquid chromatography (LC) with ultraviolet (UV) detection. The yields are typically high (>90%), and the process can be performed at room temperature without any need for vacuum or pressure conditions.

3,5-Dimethylpyrrole-2-carboxaldehyde is a molecule that has been shown to bind to the receptor tyrosine kinase (RTK) and inhibit its activity. This inhibition prevents the RTK from activating downstream pathways that promote cell proliferation. 3,5-Dimethylpyrrole-2-carboxaldehyde can also be used for the treatment of renal cell carcinomas, pancreatic stromal tumours, and neuroendocrine tumours. It has been shown to inhibit DNA synthesis in cultured cells. 3,5-Dimethylpyrrole-2-carboxaldehyde is activated by metal ions such as copper or iron to form a reactive radical species which reacts with oxygen to form superoxide radicals that are cytotoxic.

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2-Phenoxyacetaldehyde is a reactive molecule that has been shown to inhibit the growth of hematopoietic cells. It also inhibits the production of active enzymes, such as amylase, by interfering with the nucleophilic attack and oxidation of 2-phenoxyacetaldehyde. The synthesis methods for 2-phenoxyacetaldehyde include homogeneous catalysts and chemical reactions. This molecule has been used in detergent compositions, but it is not suitable for use in food contact materials because of its toxicity.

2-Hydroxy-7-methylquinoline-3-carbaldehyde is an imine with antibacterial activity. This compound has been shown to inhibit the growth of Gram-positive and Gram-negative bacteria in a biological screening. It also inhibits the growth of S. aureus, S. epidermidis, and E. coli isolates resistant to methicillin, penicillin, oxacillin, and erythromycin. 2-Hydoxy-7-methylquinoline-3-carbaldehyde is able to bind metal ions such as copper(II) or silver(I) by chelation with its carbonyl group and nitrogen atom in the imine moiety. 2HQLA also has coordination properties that can be used as a biocide or disinfectant.

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5-Hydroxypyridine-2-carbaldehyde is a glucuronide conjugate of 5-hydroxypyridine. It is an analog of the nucleotide uridine and has been used to study protein synthesis in mammalian cells. The compounds inhibitory properties are high cytotoxicity and inhibit enzyme preparations, mitochondrial membrane potential, and DNA duplexes. 5-Hydroxypyridine-2-carbaldehyde also has antitumour activity and can be used as an antiviral drug against herpes simplex virus. This compound has been shown to have a strong inhibitory effect on leukemic mice in vivo.