Antifungals

Pyrimorph is a fungicide with high activity against the plant pathogen Phytophthora capsici.

Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.

A fungicide

Faltan (Folpet), a widely used dicarboximide fungicide, induces tumors in the mouse gastrointestinal tract, primarily in the duodenum.

View and buy Ferrostatin-1 from TargetMol.Ferrostatin-1 is a potent ferroptosis inhibitor (EC50: 60 nM).Cited in 49 publications.

Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols.

Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin.

41-Oxo-rapamycin is a synthetic derivative of rapamycin, which is a macrocyclic lactone. It is derived from Streptomyces hygroscopicus, a gram-positive bacterium known for producing various bioactive compounds. The mode of action of 41-Oxo-rapamycin involves binding to the FK506-binding protein (FKBP12), forming a complex that subsequently inhibits the mammalian target of rapamycin (mTOR) pathway. This inhibition results in the suppression of T-cell proliferation and modulation of immune responses. The compound is primarily used in research settings to explore its potential applications in immunosuppressive therapies and organ transplantation. It is also a valuable tool for investigating the mTOR signaling pathway in cancer research, as it has implications in controlling cell growth and proliferation. Moreover, its role in metabolic regulation and potential neuroprotective effects are topics of ongoing study, providing insights into therapeutic approaches for various diseases, including neurodegenerative disorders and metabolic syndromes.

Fludazonium chloride (NSC-351149) is an antifungal agent.

Luliconazole (NND 502) is an Azole Antifungal. The mechanism of action of luliconazole is as a Cytochrome P450 2C19 Inhibitor.

Tolnaftate is a thiocarbamate antifungal agent with action on fungal cell membrane disruption and is used for treating fungal infections like athlete's foot, jock itch, and ringworm.

Applications (5E)-5-(3-Bromopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is an intermediate in the synthesis of 10-Hydroxy (E)-Amitriptyline (D462790). (5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).

Clotrimazole is an azole antifungal medication with action on fungal cell membrane disruption and is used for treating fungal infections like athlete's foot, ringworm, and vaginal yeast infections.

Colutehydroquinone is an antifungal isoflavonoid from Colutea arborescens.

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the

Exalamide is an arenecarboxamide antifungal agent with action on fungal growth inhibition and is used for research on fungal infections.

2-Butyl-1,2-benzisothiazolin-3-one is an orally available antimicrobial agent with antimicrobial activity commonly used in the pharmaceutical profession and

2,4,6-Tribromophenyl caproate is a potent antifungal agent.

Levofloxacin is a fluoroquinolone antibiotic with a mode of action that inhibits bacterial DNA gyrase and topoisomerase IV. It is used for treating bacterial infections like pneumonia and urinary tract infections.

Potassium acetate (Diuretic salt) with antibacterial and antifungal properties.

Kakuol inhibits Botrytis cinerea at 5µg/ml and Cladosporium cucumerinum at 3µg/ml; blocks human DNA relaxation.

Inhibitor of squalene epoxidase

Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients. Posaconazole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Ametoctradin is a Qo-site inhibitor of mitochondrial respiratory complex III and is used in the study of oomycete diseases.

Mancozeb is a fungicide of ethylene-bis-dithiocarbamate.

Stilbamidine (Ba 2652) has antifungal and anticancer activity and can be used to study multiple myeloma and bladder migratory cell carcinoma.

Ketoconazole is an azole antifungal compound with a mode of action that inhibits ergosterol synthesis, disrupting fungal cell membranes. It is used for treating fungal infections of the skin and scalp.

Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.

SQLE-IN-1 is a SQLE inhibitor with antitumor activity that inhibits the proliferation of Huh7 and the protein expression of PI3K and AKT.

Fuberidazole is an antifungal agent.

Beta-Amyrin acetate: HMGCR & sEH inhibitor (IC50 3.4 μM), anti-inflammatory, antifungal, antioxidant, anti-hyperlipidemic.

Vincetoxicoside B from Polygonum paleaceum exhibits synergistic antifungal effects with quercetin, kaempferol, and epicatechin (FICI < 0.5).

6-Chloro-7-deazapurine-β-D-riboside shows antifungal activity.

Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.

Lanoconazole is an antifungal imidazole that is potent and orally available and acts by inhibiting the synthesis of ergosterol in fungal cell membranes.

AN2718, a benzoxaborole, halts fungi protein synthesis by inhibiting LeuRS in molds/yeasts; IC50: 2 μM (A. fumigatus), 4.2 μM (C. albicans).

Metabolite of voriconazole; sterol 14?-demethylase inhibitor

Pyrimethanil is a strobilurin fungicide belonging to the anilinopyrimidine class.

Isoprothiolane is a foliar spray fungicide with eradicant and protectant activities against fungal diseases of rice plant caused by Pyvioutavia oryzae Cav.

Applications Intermediate in the preparation of insecticides, fungicides, and other pesticides. References Wilkinson, C., et al.: J. Agric. Food Chem., 14, 73 (1966), Zhong, W., et al.: J. Chem. Res., 6, 370 (2009),

Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

Solasodine, a toxic alkaloid from Solanaceae, kills HeLa cervical cancer and U937 leukemia cells.

Fengycin is a cyclic lipopeptide from Bacillus subtilis acts as a biosurfactant and antifungal. As a fungicide, it has a mode of action that involves the formation of ion channels in the fungal lipid membrane, leading to membrane leakage This activity is negatively correlated to cholesterol levels, and may explain why mammalian cells, with higher cholesterol present, are not sensitive to fengycin.

Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.

Penthiopyrad (MTF-753) shows a broad spectrum of antifungal activity and suppresses fungal respiration.

Applications Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. Alamethicin contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Afonin, S., et al.: Chembiochem., 4, 1151 (2003), Henriques, S., et al.: Biochem. J., 399, 1 (2006), Almeida, P., et al.: Biochemistry, 48, 8083 (2009), Heitz, F., et al.: Br. J. Pharmacol., 157, 195 (2009),

Applications 2-[(6-Chloro-4-pyrimidinyl)oxy]-α-(dimethoxymethyl)benzeneacetic Acid Methyl Ester is an impurity of Azoxystrobin (A965150), an strobilurin fungicide. References Liu H.J., et al.: J. Chin. Chem. Soc., 60, 27 (2013);

Exalamide (2-(Hexyloxy)benzamide) is an aromatic amide with antifungal activity used in the study of dermatophytes.

Ipconazole is a fungicide with a mode of action that inhibits ergosterol biosynthesis, disrupting fungal cell membranes. It is used for seed treatment to protect crops like cereals and vegetables from fungal diseases.

Prothioconazole (Proline 480 SC Fungicide) is a chiral triazole fungicide in plant pathogen control.

α-Terpinene is a terpenoid,has acaricidal, antiprotozoal, and antioxidant properties

Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).

Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity.

2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1].

Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.

Flumorph (SYP-L190) (SYP-L190) is a carboxylic acid amide fungicide.

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.

2-Methyl-4-isothiazolin-3-one HCl , also known as MIT hydrochloride is often used as a preservative in personal care products and other industrial applications. The product has shown to act as an antimicrobial and antifungal agent.