Antifungals

5-Heneicosylresorcinol inhibits β-hexosaminidase, prevents fat in 3T3-L1 cells, kills nematodes with ED50: 80, 30, 180 ug/mL.

Applications [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (cas# 345637-71-0) is a useful research chemical. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

PNU288034 is a potent oxazolidinone antibiotic with antimicrobial activity for the prevention and treatment of Gramnegative infections.

2-Methyl-4-isothiazolin-3-one or MIT is a powerful antimicrobial and antifungal agent which is widely used in personal care products. It is also used in industrial applications as a preservative and antifouling agent.

Enilconazole, also known as Imazalil, is a fungicide for citrus agriculture.

Efinaconazole (KP-103)(KP-103) is an Azole Antifungal currently under development as a topical treatment for onychomycosis.

Delafloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating acute bacterial skin and skin structure infections.

ACHE-IN-38, an Acetylcholinesterase inhibitor, can be used to synthesize compounds with anti-inflammatory activity.

Micafungin, as one of three echinocandina, has been proven to be a successful antifungal therapeutic in treating general Candida fungus infections. The treatment of immunocompromised patients is particularly important as Candida infections cause high mortality rates in patients in intensive care units, receiving chemotherapy, or stem cell transplants. This product acts as an anti-fungal by inhibiting the 1,3-beta-D-glucan synthase enzyme. As a result the production of 1,3-beta-D-glucan, which is crucial to the fungal cell wall, is hindered. Thus, the fungal cell wall loses integrity allowing for osmotic instability and cell lysis to occur. Micafungin sodium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Difenoconazole, a broad-spectrum triazole fungicide, blocks ergosterol production, disrupting fungal cell membranes and causing cell death.

iKIX1 reactivates Pdr1 genes, reversing C. glabrata's azole antifungal resistance in vitro and in vivo.

Fungicide

Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities.

QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.

Applications 3(2H)-Isoxazolone is a 3-hydroxyisoxazole with fungicidal activity. 3(2H)-Isoxazolone is an impurity of Cycloserine (C988800). References Takahi, Y.: San. Kenk. Nen., 25, 8 (1973);

Filastatin is a long-lasting inhibitor of Candida albicans filamentation, and has potent antifungal effect.

Anthelmintic; inhibitor of tubulin polymerization

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. Caspofungin acetate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

21-Norrapamycin is a macrocyclic lactone antibiotic, which is derived from the bacterium Streptomyces hygroscopicus. Its chemical structure is closely related to that of rapamycin, a well-known immunosuppressant. The mode of action of 21-Norrapamycin involves the inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway. By binding to the FK506-binding protein 12 (FKBP12), it forms a complex that then inhibits mTOR, a crucial regulator of cell growth, proliferation, and survival. This compound is pivotal in research focused on cellular and molecular biology, particularly in understanding processes related to cancer, aging, and metabolic disorders. Due to its ability to inhibit mTOR signaling, 21-Norrapamycin has been utilized in studies exploring novel therapeutic approaches for diseases where aberrant mTOR activity is implicated. It provides a valuable tool for dissecting the intricate pathways that govern cell metabolism and proliferation, offering insights that could lead to the development of new pharmacological interventions.

Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci,

FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. 

Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.

Filipin is a polyene macrolide antifungal agent with action on cholesterol in cell membranes and is used for histochemical staining and research on cholesterol metabolism.

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Fluazinam: a pyridinamine fungicide, broad-spectrum, strongly inhibits S. sclerotiorum mycelial growth.

Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect against

1-(6-Amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a fluoroquinolone antibiotic, engineered through synthetic chemistry. It is derived from chemical sources involving complex organic synthesis, highlighting its intricate molecular architecture. Its mode of action is distinctive, as it inhibits bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription. This interference with bacterial DNA processes results in bactericidal effects, effectively eliminating susceptible bacterial strains. This compound serves primarily in the treatment of various bacterial infections, demonstrating utility against a range of gram-positive and gram-negative bacteria. Its application extends to clinical settings where resistant bacterial strains pose significant challenges, making it a critical tool in antimicrobial therapy. The structural sophistication of this compound allows it to maintain efficacy where other antibiotics may fail, due to its enhanced binding affinity and resistance to common resistance mechanisms.

Thifluzamide is a fungicide widely used to control crop diseases.

Anti-fungal; glucan synthase inhibitor

Myclobutanil (Systhane) is a triazole chemical used as a fungicide.

Fenticonazole nitrate is an imidazole antifungal agent with action on fungal cell membrane disruption and is used for treating fungal infections like vaginal thrush and athlete's foot.

Triticonazole is a triazole pesticide and fungicide. Triticonazole shows endocrine disrupting activities.

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human.

Activator of the two-pore domain potassium channel TASK3

Prodigiosin is a secondary metabolite of Symbiotic bacteria. It also has anti-fungal and anti-cancer activity.

Chlormidazole hydrochloride (Clomidazole hydrochloride) has inhibitory activity against many fungi and some gram-positive cocci.

Atovaquone is an antimicrobial drug that is used for the treatment of Pneumocystis jirovecii pneumonia. This drug is an analog of ubiquinone and has good in vitro activity against Toxoplasma gondii. Atovaquone is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Xanthoxylin (Brevifolin) is a borneol and camphor tasting compound and can be found in a number of food items such as fats and oils, herbs and spices,

PC945 (Opelconazole) is an antifungal compound that inhibits CYP51A/CYP51B and can be used to study fungal infections of the lungs.

Applications Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase. References Arch. Biochem. Biophys., 221, 593 (1983), Clin. Biochem., 17, 3 (1984), Trends Bio. Sci., 9, 32, (1984), J. Biol. Chem., 260, 15873-15879 (1985), FEBS, 1985, 28 (1986)

Flutrimazole: a dual-action imidazole with anti-inflammatory and antifungal effects; ideal for topical use due to limited skin penetration.

Applications CSA (cationic steroid antibiotics) is a class of facial amphiphiles with same mechanism of antimicrobial action as that of CPAs (cationic peptide antibiotics). References Sundriyal, S., et al.: J. Mol. Model, 14, 265 (2008).

SDZ285428 is a CYP24A1 inhibitor.

Amorolfine is an antifungal drug that inhibits fungal enzymes (D14 reductase and D7-D8 isomerase). Its inhibition has an affect on fungal sterol synthesis pathways, and it depletes ergosterol. This drug can be used as a treatment for inflammatory lesions such as Tinea corporis, Tinea pedis, and Tinea cruris due to its ability to penetrate the skin barrier with ease. Amorolfine HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.