Antivirals

Alamifovir is an antiviral agent, which is synthetically derived. The mode of action of Alamifovir involves the inhibition of viral replication within host cells by targeting specific viral enzymes crucial for the replication process. This interference with the viral life cycle diminishes the ability of the virus to propagate and spread within the host organism. Alamifovir is primarily used in the treatment of viral infections, potentially offering therapeutic benefits for diseases caused by DNA viruses. Its effectiveness is contingent upon its ability to selectively target viral components with minimal cytotoxic effects on host cells, ensuring a beneficial therapeutic index. The applications of Alamifovir in antiviral therapy highlight its relevance in the continuous search for effective treatments against viral pathogens that pose significant clinical challenges. Research into Alamifovir's pharmacokinetics, safety profile, and resistance patterns is ongoing, with the aim of optimizing its use in clinical settings and expanding its utility across a broader spectrum of viral infections.

Applications Darunavir intermediate. References Ghosh, A., et al.: J. Med. Chem., 39, 3278 (1996), Ghosh, A., et al.: Bioorg. Med. Chem. Lett., 1998, 8, 687 (1998), Richman, D., et al.: Nature, 410, 995 (2001), Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003),

LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.

Applications A highly reactive thiol-specific spin-label. A specific conformational probe of thiol site structure by virtue of its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study.

EIDD 2801 is an orally bioavailable prodrug of β-D-N4-hydroxycytidine and was shown to inhibit SARS-CoV-2 replication in human airway epithelial cells. EIDD 2801 was also tested in mice infected with SARS-CoV and MERS-CoV viruses. EIDD 2801 targets the RNA-dependent RNA polymerase (RdRp) and reduces virus titer and improved pulmonary function in experimental animals when used in prophylactic and therapeutic regime.

Applications Tenofovir (T018500) derivative.

Stability Hygroscopic Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.

Azvudine hydrochloride (RO-0622 hydrochloride) is an NRTI inhibitor with antiviral activity, inhibiting HIV, HBV and HCV.

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

Applications Atazanavir intermediate. Enantiomer S. References Vassar, R., et al.: Science, 286, 735 (1999), Maillard, M., et al.: J. Med. Chem., 50, 776 (2007), Stauffer, S., et al.: Bioorg. Med. Chem. Lett., 17, 1788 (2007),

Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

Tenofovir alafenamide (free base) is a prodrug of tenofovir with action on viral reverse transcriptase to block replication and is used for treating HIV/AIDS and chronic hepatitis B with improved safety profile.

BMS 806 is an antiretroviral agent and is used for the treatment of HIV. It inhibits the fusion of the HIV virus with the host cell membrane.

Arg-AMS is an arginine tRNA synthetase inhibitor with antiviral activity for the study of viral infections and myeloma.

Anti-viral; inhibitor of cytomegalovirus-terminase complex

Cytarabine is also known as cytosine arabinoside (ara-C) and is a chemotherapy drug that works by inhibiting DNA synthesis. It acts as a nucleoside analogue, which is incorporated into the growing DNA chain during replication. Cytarabine combines a cytosine base with an arabinose sugar (1β-arabinofuranosylcytosine) and is an analog for human deoxycytosine. Cytarabine interferes with DNA synthesis as it is rapidly converted to cytosine arabinoside triphosphate, damaging DNA when cells are in the synthesis phase (S phase). Tumor cells which are highly mitotic and growing rapidly are therefore preferably targeted. Cytarabine also inhibits nucleotide reductase enzymes as well as nuclear polymerases, leading to interruption and inhibition of synthesis, strand breaks and cell death. Cytarabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Famciclovir (BRL 42810) inhibits Herpes virus DNA polymerase by mimicking nucleosides.

Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性,可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。

Tropone is a non-benzene aromatic organic compound antiviral and antifungal.Tropolone derivatives inhibit the replication of HBV at the submicromolar level.

GSK 2838232 is a HIV-1 maturation inhibitor with action on HIV-1 Gag protein cleavage and is used for research on HIV treatment.

Stability Hygroscopic Applications Lamivudine-13C1,d2, is the labeled analogue of Lamivudine (L172502). A reverse transcriptase inhibitor. Antiviral. References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977),

Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),

Applications T-705RMP TEA Salt is a metabolite of T-705RMP (CAS# 356783-08-9), which is a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections. T-705 (Favipiravir) [F103350] gets converted to T-705RMP by host cells, but T-705RMP has little inhibitory effect on the replication of the host cells based on biological studies. References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014); Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005)

Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.

Applications An antiviral agent; nucleoside analog with antihepatitis B activity. References Watanabe A., et al.: J. Med. Chem., 22, 21 (1979), Colacino, J.M., et al.: Antimicrob. Agents Chemother., 24, 505 (1983), Staschke, K.A., et al.: Antiviral Res., 23, 45 (1994), Cui, L., et al.: J. Clin. Invest., 95, 555 (1995),

Isomyosmine inhibits nitrate reductase and reduces oxidative stress. Isomyosmine is used to study inflammation and virus infection related to oxidoreductase.

Applications Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir is an intermediate for the synthesis of Atazanavir (A790051) and the preparation of some peptide analogs. References Martin, J., et al.: Prog. Med. Chem., 32, 239 (1995), Jadhav, P., et al.: J. Med. Chem., 40, 181 (1997), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998);

Impurity USP Ribavirin Related Compound A Applications Ribavirin Carboxylic acid is an impurity of Ribavirin (R414475). Ribavirin impurity A. References Lertora, J., et al.: Clin. Pharmacol. Ther., 50, 442 (1991), Connor, E., et al.: Antimicrob. Agents Chemother., 37, 532 (1993), Manns, M., et al.: Lancet, 358, 958 (2001),

Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

(S)-HPMPA is a nucleotide analogue, which is a chemically synthesized compound designed to mimic nucleotides. It acts as both an antiviral and an antitumor agent, sourced primarily through synthetic chemistry involving the modification of naturally occurring nucleotide structures. The mode of action of (S)-HPMPA involves mimicking natural substrates of various viral polymerases and cellular enzymes, thereby inhibiting viral DNA synthesis and disrupting the replication cycle of DNA viruses. Additionally, it can interfere with certain cellular pathways contributing to its antitumor effects. The primary applications of (S)-HPMPA include research in virology, particularly focused on understanding viral replication mechanisms and developing new antiviral therapies. It has shown activity against a range of DNA viruses, including herpesviruses and cytomegaloviruses, and has potential uses in oncology as a supportive agent in antitumor research. The compound's ability to integrate into ongoing biochemical pathways provides valuable insights into enzyme-substrate interactions and cellular responses to analog interference, making it a significant tool in molecular biology and pharmaceutical research.

Stability Hygroscopic Applications Tenofovir (T018500) impurity.

PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .

Antiviral; nonpeptidic HIV-1 protease inhibitor

FV-100 (Valnivudine HCl), API for CF-1743, is a potent, oral anti-vaxx-zoster drug with low in vivo toxicity.

DDX3-IN-2 is a potent DDX3 inhibitor with an IC50 of 0.3 μM and shows broad antiviral effects, including against HIV resistance.

Pimodivir is a non-nucleoside-derived inhibitor of the polymerase basic protein 2 (PB2) subunit found in the polymerase complex of the influenza A virus. In general, pimodivir is indicated for the treatment of patients with severe influenza although knowledge about possible rise of resistance is not available.

Applications An impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.

Anti-viral; NS3/4A protease inhibitor_x000D_

Darizmetinib (HRX215) is an MKK4 inhibitor.

Dapivirine is a non-nucleoside reverse transcriptase inhibitor with action on HIV-1 reverse transcriptase and is used for preventing HIV infection through vaginal rings.

Stability Very Hygroscopic and Temperature Sensitive Applications Tenofovir Disoproxil impurity. References Cheng, G., et al.: Chem. Res. Toxicol., 16, 145 (2003),

Rociclovir has antiviral activity and is used to treat viral infections.

Chelidonine from Chelidonium majus triggers HeLa cell apoptosis, may reverse MDR, boost chemotherapeutics against leukemia, and inhibit cancer cell metastasis.

Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product. References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),