Antivirals

Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Impurity Ritonavir EP Impurity L Applications Desthiazolylmethyl Ritonavir (Ritonavir EP Impurity L) is an analogue of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product. References Brittain, H., et al.: Pharm. Res., 8, 963 (1991), Sham, H., et al.: J. Med. Chem., 39, 392 (1996), Phadnis, N., et al.: J. Pharm. Sci.,86, 1256 (1997), Bauer, J., et al.: Pharma. Res., 18, 859 (2001),

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment

Tenofovir disoproxil is a nucleotide analog reverse transcriptase inhibitor that is used to treat infections such as Hepatitis-B and HIV. This drug is an antiretroviral agent that blocks reverse transcriptase, blocking viral replication. Tenofovir disoproxil fumarate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

R 61837 is a novel rhinovirus inhibitor, a substituted phenylpyridazinamine, with antiviral activity.

Stability Hygroscopic Applications An impurity of Tenofovir Disoproxil (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. It is used as an anti-HIV agent and an antiviral. References Gan, L., et al.: Drug Metab. Dispos., 24, 344 (1996), Annaert, P., et al.: Pharm. Res., 14, 492 (1997), Naesens, L., et al.: Antimicrob. Agents Chemother., 42, 1568 (1998), Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Impurity Atazanavir Impurity C Applications Atazanavir intermediate. Enantiomer R. Atazanavir Impurity C References Vassar, R., et al.: Science, 286, 735 (1999), Maillard, M., et al.: J. Med. Chem., 50, 776 (2007), Stauffer, S., et al.: Bioorg. Med. Chem. Lett., 17, 1788 (2007),

Impurity Aciclovir EP Impurity J Applications O-(Guanin-9-yl)methyl Acyclovir (Aciclovir EP Impurity J) is a dimer impurity of the antiviral agent Acyclovir (A192400). References Ashton, D.S. et al.: J. Chrom. A, 707, 367 (1995);

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

CpG ODN 10101 (CPG 10101) is an oligodeoxynucleotide agonist of TLR9 with antiviral activity for the treatment of chronic infections.

1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.

Applications (R)-Telaprevir-d4 is the labeled analog of (R)-Telaprevir, an enantiomer of Telaprevir (T015650). Telaprevir is an known inhibitor of the hepatitis C virus NS3-4A protease. It is a COVID19-related research product. References Francois, J., et al.: J. Medn. Chem., 52. 7993 (2009); Kieffer, T., et al.: Hepatology, 46, 631 (2007), Zhou, Y., et al.: Antimicrob. Agents Chemother., 52, 110 (2008), Hezode, C., et al.: N. Engl. J. Med., 360, 1839 (2009);

Paederoside deters beetles, isolated from aphids, and inhibits tumor-promotion in Epstein-Barr virus.

Ombitasvir is a NS5A inhibitor antiviral agent with action on hepatitis C virus replication and is used for treating chronic hepatitis C in combination therapies.

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) medication used in the treatment of human immunodeficiency virus (HIV) infections. It works by blocking reverse transcriptase, an enzyme essential for replication of the virus, thereby preventing the virus from multiplying and spreading. Etravirine is often used in combination with other antiretroviral drugs to effectively treat HIV/AIDS. It is commonly prescribed for patients with virus strains that are resistant to other NNRTI medications due to mutations that confer resistance- mutations K103N and Y181C. Etravirine is a diarylpyrimidine (DAPY) and has conformational isomerism meaning that it binds reverse transcriptase in an fleible manner, under multiple conformations. The impact of specific point mutations in the virus is therefore lessened. Etravirine is part of our Bio-X™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Valacyclovir is a guanine nucleoside antiviral drug that is used to treat herpes exacerbations. This drug inhibits DNA polymerase and prevents viral DNA synthesis. Valacyclovir is the L-valine ester of acyclovir. L-Valacyclovir HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir.

Applications N-De-4-ethyl-2-isopropylthiazole Ritonavir N-(Thiazol-5-ylmethyl ((2S,3S)-3-Hydroxy-1,6-diphenylhexan-2-yl)carbamate) is an impurity of Ritonavir (R535000), a selective HIV protease inhibitor. It is a COVID19-related research product. References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003); Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)

Glaucine: antitussive, antioxidative, antiviral, may fight arthritis, boosts IL-10, hinders breast cancer cell spread by inhibiting MMP-9 and NF-κB.

5-Fluorocytidine with antiviral activity

Applications Bifendate is a synthetic intermediate of Schisandrin C and also a anti-HBV drug used in the treatment of chronic hepatitis B. References Pan, S.Y., et al.: Euro. J. Pharmacol. 522, 170 (2006); Zeng, Y., et al.: Acta. Pharmacol. Sinica., 30, 478 (2009);

Rupintrivir is a peptidomimetic antiviral with action on rhinovirus 3C protease to inhibit viral replication and is used for research on rhinovirus and other viral infections.

GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.

BMS 806 is used as an anti-viral agent. It has been shown to inhibit the replication of HIV. BMS 806 inhibits viral life by binding to the surface glycoproteins and inhibiting viral entry into cells. The drug also inhibits viral replication by preventing DNA transcription and translation. BMS 806 is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Baloxavir marboxil is a selective inhibitor of the cap-dependent endonuclease of RNA polymerase, an acidic protein in influenza A and B viruses. In patients, baloxavir marboxil reduces the time to recovery by alleviating the symptoms of the influenza A and B infection, in both adults and children.

2'-beta-C-Methyl inosine (2'-C-Methyl inosine) is an HCV RNA polymerase inhibitor with antiviral activity and may be used in studies to treat hcv infections.

Oxamisole TFA is an orally available T-cell immune repair agent.

Viroxime has anti-rhinoviral activity and may be used to study poliovirus infections.

WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and may be used in the study of small ribonucleic acid virus infections.

Applications (S)-(5S,6S,8S)-5,8-Dibenzyl-12,12-dimethyl-3,10-dioxo-1-(thiazol-5-yl)-2,11-dioxa-4,9-diazatridecan-6-yl 2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate is an protected prodrug of Ritonavir (R535000), which is a selective HIV protease inhibitor.

Selective and potent inhibitor of sialidases (neuraminidases) in influenza A and B viruses. The compound binds tightly to the viral neuraminidase active site in late stages of viral life-cycle. It inhibits shedding sialic acids from host cell surface glycans, which interact with viral hemagglutinin, and consequently prevents release of new viral particles from the host cell surface.

Applications A Cobicistat (C633150) impurity. Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. It inhibits the activity of HIV-1 integrase, which impedes the insertion of HIV-1 DNA into the host cell genome. Raltegravir also inhibits resistant mutants of HIV-1 that are associated with disease activity and progression. Raltegravir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Cannabigerolic acid has antiviral activity and inhibits the TRPM7 ion channel, and is used in the study of acute respiratory syndrome.

Applications The N-dealkylated metabolite (M1) of Atazanavir (A790051), a HIV protease inhibitor. References Heine, R., et al.: Drug Metab. Dispos., 37, 1826 (2009),

Potent antiviral against HCMV and Epstein-Barr virus (EBV)

Applications 1-[2-Deoxy-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]-1H-1,2,4-triazole-3-carboxamide is an intermediate in the synthesis of 2’-Deoxyribavirin-5’-triphosphate (D2149940) Triethylamine Salt, a potential new inhibitor for HIV-1 replication. References Vivet-Boudou, V., et al.: Nucleos. Nucleot. Nucl., 26, 743 (2007);

SHEN26 has antiviral activity and can be used in research on the treatment of viral infections.

Acetyl daclatasvir is a direct-acting antiviral agent, which is chemically derived from a series of small-molecule inhibitors. The source of this compound lies in rational drug design, focusing on targeting specific viral proteins involved in the replication of hepatitis C virus (HCV). Its mode of action involves inhibiting the NS5A protein, a non-structural protein essential for HCV RNA replication and virion assembly. By binding to NS5A, acetyl daclatasvir disrupts the replication complex, effectively halting the virus's ability to multiply within the host cells. The primary uses and applications of acetyl daclatasvir are centered around its role in hepatitis C research, where it is utilized to study viral life cycles and evaluate antiviral efficacy in laboratory settings. Given its specificity and potency, acetyl daclatasvir serves as a critical tool in the development of therapeutic strategies and understanding HCV biology.

Applications Stavudine-alpha,alpha,alpha,6-d4 (CAS# 1219803-67-4) is a useful isotopically labeled research compound.

Applications 2-Acetoxy-N-(2-thiazolyl)-benzamide is used in the synthesis of thiazolides as novel antiviral agents. Used in the inhibition of hepatitis C virus replication. Nitazoxanide Impurity References Edwards, G. et al.: J. Med. Chem., 54, 8670 (2011);

Famciclovir is a guanosine analogue antiviral agent that is used for the treatment of various herpesvirus infections, most commonly for herpes zoster. It works by inhibiting the replication of the herpes virus. Famciclovir prevents viral DNA synthesis by inhibiting the viral DNA polymerase and by blocking viral DNA replication. Its active form is penciclovir. Famciclovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

GFP16 is a compound with potential prion antiviral activity, used in prion research.