Antivirals

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Yadanziolide A is a natural product isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against

Applications Labelled Biliverdine is a precursor of Bilirubin. Biliverdine is formed in the body from hemoglobin. The bile of amphibians and of birds contains Biliverdine only. It is also an inhibitor for hepatitis C virus. References Lemberg et al.: Biochem. J., 35, 363 (1941); Gutierrez-Grobe, Y. et al.: Annals. Hepatol., 10, 105 (2011);

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

Nucleoside analog with antiviral activity against coronaviruses, hepatitis and influenzas viruses. EIDD 1931 inhibited the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the murine hepatitis virus (MHV) replication in vitro at submicromolar concentrations. EIDD 1931 is able to evade the proofreading exonuclease ExoN and presents with high barrier to development of drug resistance.

Anti-viral; thymidine analogue; DNA plymerase inhibitor

Applications Dasabuvir is an antiviral drug used in the treatment of chronic hepatitis C virus (HCV) infection. References Khatri, A., et al.: J. Hepatol., 63, 805 (2015);

Anti-viral; HIV integrase inhibitor

Dalimycin (Oxytetracycline Hydrochloride), from Streptomyces rimosus, blocks tRNA binding, hindering protein synthesis.

Inhibitor of viral protein NS5B

MK-28 is a PERK agonist that reduces toxicity in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.

Non-nucleoside inhibitor of reverse transcriptase; anti-viral

Stability Hygroscopic Applications Tenofovir (T018500) impurity.

Stability Moisture sensitive Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),

Ledipasvir D-tartrate is an antiviral compound, which is a direct-acting antiviral agent used in the treatment of hepatitis C virus (HCV) infection. It originates from synthetic sources designed to inhibit the replication of specific viral proteins. Ledipasvir functions by targeting the NS5A protein of the hepatitis C virus, a key component necessary for viral replication. By binding to this protein, Ledipasvir disrupts and inhibits the HCV replication complex, effectively suppressing the viral load in patients. Utilized primarily in the context of chronic hepatitis C treatment, Ledipasvir D-tartrate is typically employed in combination with other antiviral medications, such as sofosbuvir, to enhance therapeutic efficacy. This combination therapy has shown significant success in achieving sustained virologic response in various genotypes of HCV, reducing morbidity and preventing progression to liver-related complications. The use of Ledipasvir D-tartrate in clinical settings underscores its importance in modern antiviral strategies against chronic HCV infection, representing a critical advancement in the management of this pervasive viral disease.

6-Fluoro-3-hydroxypyrazine-2-carboxamide is a potent RNA polymerase inhibitor, active against both RNA viruses in vitro and in vivo. A four-step approach to the synthesis of 6-Fluoro-3-hydroxypyrazine-2-carboxamide was reported in 2014. 6-Fluoro-3-hydroxypyrazine-2-carboxamide is commercialized and has recently been suggested for the treatment of mild cases of COVID-19.

Inhibitor of HIV-1 integrase strand transfer; antiviral

Zapnometinib (ATR-002) is a MEK inhibitor.

RNA polymerase (RdRp) inhibitor

FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).

Rociclovir PM (2-[(2-aminopurin-9-yl)methoxy]propane-1,3-diol) is a compound with antiviral activity

Applications N,9-O-Diacetylneuraminic Acid is a primary receptor determinant of influenza C virus. References Rogers, G., et al.: J. Biol. Chem., 261, 5947 (1986); Herrler, G., et al.: EMBO J., 4, 1503 (1985);

Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.

Impurity Tenofovir Impurity Stability Light Sensitive Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Tirilazad mesylate (U 74006F) is a lipid peroxidation inhibitor with antiviral activity.Tirilazad mesylate is used in the study of neurological disorders.

Applications Oseltamivir EP Impurity E Glucose Adduct is a byproduct in the synthesis of Oseltamivir Glucose Adduct 1 (O701035), which is derived from Oseltamivir Phosphate (O701000), which is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite (an antiviral drug). It is a COVID19-related research product. References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

Stability Hygroscopic Applications Oseltamivir 5-Desamino 5-(2-Formyl 5-Hydroxymethylpyrrol-1-yl) is derived from Oseltamivir Phosphate (O701000), which is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product. References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

Applications 2'-Fluoro-2'-deoxyuridine-5,6-d2 (CAS# 362049-50-1) is a useful isotopically labeled research compound.

Anti-viral; capsid inhibitor

SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.

Applications Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV). References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Applications 2-Hydroxy-2-methylpropanethioamide is an thioamide compound integrated as an constituent in the synthesis of Ritonavir (R535000) and its derivatives.

Peramivir is a neuraminidase inhibitor used to treat influenza by preventing virus release from cells.

Tenofovir diphosphate is an antiviral compound, which is a key active metabolite derived from the prodrugs tenofovir disoproxil fumarate and tenofovir alafenamide, both originating from chemical synthesis. Its mode of action involves inhibiting the activity of HIV-1 reverse transcriptase by competing with the natural substrate, deoxyadenosine 5’-triphosphate, and causing chain termination after incorporation into viral DNA. This mechanism effectively prevents the replication of retroviral DNA, thus halting the progression of the infection. The primary uses and applications of Tenofovir diphosphate focus on the treatment and prevention of human immunodeficiency virus (HIV) infection. It plays a crucial role in antiretroviral therapy regimens due to its potency and high barrier to resistance. Additionally, it is employed in pre-exposure prophylaxis (PrEP) strategies for individuals at high risk of contracting HIV. The inclusion of Tenofovir diphosphate in combination therapies enhances the overall efficacy and durability of the antiviral response in patients, contributing significantly to the management of HIV/AIDS.

CBS1117: influenza A entry inhibitor; blocks HA fusion, IC50=70 nM for H1N1.

Applications A reactant used in the preparation of carbocyclic deoxyguanosine analog with potent and selective anti-hepatitis B virus. References Bisacchi, G. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997)

Ethacrysta hydrochloride (GNS561 hydrochloride) is a PPT1 inhibitor with antifibrotic properties and may be used in studies of hepatocellular carcinoma.

Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

ABI-1968 has antiviral and antitumor activity and can be used to study immune system diseases.

Stability Hygroscopic Applications Digallic Acid is an intermolecular ester of Gallic acid (G188900), a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities. References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981)

Anti-viral; non-nucleoside reverse transcriptase inhibitor

Abacavir sulfate is an antiviral drug that belongs to the class of HIV protease inhibitors. It is used in combination with other antiretroviral drugs to treat HIV-1 infection. Abacavir sulfate inhibits viral replication by blocking the activity of HIV-1 protease, which is necessary for the production of new virus particles. Abacavir sulfate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Daclatasvir (EBP 883/BMS-790052) is a potent HCV NS5A inhibitor with EC50 9-50 pM across various genotypes. Phase 3.

Atazanavir is a HIV-1 protease inhibitor, used in the anti-retroviral therapy of adult and sometimes paediatric patients infected with HIV. In in vitro studies with human pulmonary epithelial cells, atazanavir has been studied as a potential inhibitor of SARS-CoV-2 Mpro protease, with the aim of halting viral replication.

Stability Hygroscopic Applications Oseltamivir-d5 Phosphate is the isotope labelled analog of Oseltamivir (O701000); an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. Also an antiviral drug. It is a COVID19-related research product. References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

AMC-01 has potential antiviral activity and induces dose- and time-dependent inactivation of eIF2-α via phosphorylation of serine residue 51.