Antivirals

Potent and selective inhibitor of influenza A and B sialidases. Zanamivir belongs to the class of drugs known as neuraminidase inhibitors. This compound is a sialic acid analogue that occupies viral neuraminidase active site, inhibits enzyme’s hydrolytic activity and cleavage of sialic acid residues from host cell surface glycans. It therefore prevents shedding newly produced virions from infected cell surface and reduces infection of surrounding cells. In in vitro studies with influenza A and B virus isolates, zanamivir inhibited the plaque formation by 50% in canine cells (MDCK) with concentrations between 0.004 and 0.014 μM and 0.02 and 16 μM, respectively. Zanamivir hydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.

Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.

Applications Oseltamivir Acid Hydrochloride is a metabolite of Oseltamivir (O701000), an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product. References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

A competitive inhibitor of HCV NS3/4A protease that blocks viral replication. Efficacious in treating HCV-infected patients in combination with daclatasvir. Asunaprevir-resistant replicons are sensitive to NS5A replication complex inhibitor, suggesting potential combination therapy.

Applications Lopinavir D-Valine Diastereomer-d9 is the isotope labelled analog of Lopinavir D-Valine Diastereomer. Lopinavir D-Valine Diastereomer is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product. References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

Impurity Oseltamivir EP Impurity F; Applications 3-Des(1-ethylpropoxy)-3-(1-methylpropoxy) Oseltamivir (Oseltamivir EP Impurity F) is an impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.

ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.

Impurity Atazanavir Impurity (Pyridinyl Benzoic Acid) Applications Reactive metabolite of Atazanavir (A790051). Atazanavir Impurity (Pyridinyl Benzoic Acid) References Li, F. et al. Drug Metab. Disp., 39, 294 (2011);

Applications A new antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza. References Whitley, R., et al.: Pediatr. Infect. Dis. J., 20, 127 (2001), Bright, R., et al.: Lancet., 366, 1175 (2005), Deyde, V., et al.: J. Infect. Dis., 196, 249 (2007), Lee, N., et al.: Clin. Infect. Dis., 46, 1323 (2008),

Applications Protected Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research. References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Cephalotaxine (ZINC19795976) is an antiviral and an antitumor agent.

Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral. References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),

Applications A model compound for studies of binding of influenza virus hemaglutinin and metal ions. References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989), Sharon, N., et al.: Science, 246, 227 (1989), Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992), Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)

Anti-viral; RNA polymerase inhibitor; sofosbuvir metabolite

Applications Ritonavir O-Sulfate is a metabolite of Ritonavir (R535000); a selective HIV protease inhibitor. It is a COVID19-related research product. References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Denissen, J.F., et al.: Drug Metab. Dispos., 25, 489 (1997)

Applications Reactant used in the synthesis of many anthocyanins and anti-HIV agents. References Xie, L. et al.; J. Med. Chem. 42, 2662 (1999).

Cletoquine, Hydroxychloroquine's active metabolite, fights CHIKV, has antimalarial properties, and may treat autoimmune diseases.

Inhibitor of viral neuraminidase enzyme, effective against influenza A and B viruses. This antiviral compound inhibits neuraminidase-mediated cleavage of host cell sialic acids, which interact with newly synthesised virions from the host cell. This prevents virion budding from the host, resulting in inhibition of virion release and viral infection overall.

Stability Hygroscopic Applications Tenofovir (T018500) impurity.

Nucleoside reverse transcriptase inhibitor; anti-Hepatitis B virus

Applications Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product. References Vacca, J.P., et al.: Proc. Nat. Acad. Sci. USA, 91, 4096 (1994), Dorsey, B. D., et al.: J. Med. Chem., 37, 3443 (195), Balani, S.K., et al.: Drug Metab. Dispos., 23, 266 (1995)

DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture.

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product. References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Stability Moisture Sensitive Applications Tenofovir Alafenamide-d5 Fumarate (diastereomers), is labeled GS 7171. Tenofovir Alafenamide (T018555) is an isomer of GS 7171.

Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities

YM-53403: Antiviral that combats both RSV subgroup A/B, treats respiratory infections.

Applications Intermediate in the synthesis of ent-Emtricitabine (E525005).

Stability Hygroscopic Applications Tenofovir Disopropyl Ethyl Diester is an impurity of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis. Cidofovir dihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Dasabuvir is a non-nucleoside NS5B polymerase inhibitor with action on hepatitis C virus RNA replication and is used for treating hepatitis C in combination therapies.

Esculin (Aesculin) is a glucoside found in horse chestnuts.

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis. Cidofovir anhydrous is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

DPPG is a useful organic compound for research related to life sciences. The catalog number is TF0060 and the CAS number is 200880-41-7.

Impurity Ribavirin EP Impurity D Applications N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research. References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Aristeromycin is an adenosine analog and an antibiotic and. It is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor.

Imiquimod 2HCl is a toll-like receptor 7 (TLR7) agonist and an immunomodulator with antiviral and antitumor activity.

BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.

Foscarnet sodium is a pyrophosphate analog antiviral agent with action on viral DNA polymerase and is used for treating cytomegalovirus and herpes simplex virus infections.