Antivirals

Anti-viral; inhibitor of NS5A protein

2-Hydroxy myristic acid, found in milk, cheese, fish, and wool, blocks enterovirus and Junin/Tacaribe virus replication; weak myristoylation inhibitor.

3’-O-Methyladenosine is an antiviral compound with inhibitory activity against West Nile Virus and can be used for the treatment of viral infections.3’-O-

A compound with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 µM.

Stability Hygroscopic Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.

Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.

Stability Hygroscopic Applications (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate. References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

Anti-viral; HIV protease inhibitor

UC-781, a potent NNRTI, inhibits HIV-1 with a C50 of 5 nM and is stable across pH and temperatures.

Cidofovir dihydrate: Injectable anti-CMV; suppresses CMV by inhibiting viral DNA polymerase; treats CMV retinitis in AIDS.

Epetirimod (S-30563) is a small molecule immunomodulator with antitumor and anti-infective activity for the study of papillomavirus infections.

Adenosine analogue with antiviral activity

Applications (2'R)-2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

Sinapaldehyde glucoside is a glycoside isolated from the bark of Ilex rotunda, demonstrating antioxidant activity, inhibiting bacterial and fungal growth.

EIDD-2749 (4'-Fluorouridine), an oral drug, inhibits RdRp, halts RSV/SARS-CoV-2 replication, and fights HCV/LCMV.

Applications Des(isopropylthiazolyl)-N-methyl Ritonavir is a a product of the decomposition of Ritonavir (R535000). It is a COVID19-related research product. References Tiwari, R.N., Bonde, C.G.: Anal. Method, 3, 1674 (2011)

Applications Cladribine 5’-Monophosphate Ammonium Salt can be used as an antiviral, antibacterial and antileukemic agent. References Cook, P., et al.: U.S., US 4719295 A 19880112 (1988);

SE 563 is a biocontrol agent, which is an organism-based product derived from natural sources. It is sourced from a specific strain of entomopathogenic nematodes known for their effectiveness in targeting and controlling insect pests. The mode of action involves the nematodes seeking out their insect hosts in the soil, entering through natural openings, and releasing symbiotic bacteria that kill the host from within. SE 563 is primarily utilized in integrated pest management (IPM) programs for agriculture. Its applications include controlling a wide range of soil-dwelling insect pests, such as grubs and larvae, which can cause significant damage to crops. By targeting pests specifically and reducing the reliance on chemical pesticides, SE 563 contributes to sustainable agriculture and environmental health. Scientists and agricultural experts employ SE 563 to enhance crop yields while minimizing ecological impact, offering a promising solution in the realm of agricultural pest management.

Viramidine hydrochloride is an antiviral prodrug with action as a precursor to ribavirin, targeting viral RNA synthesis and is used for research on hepatitis C and other viral infections.

Darunavir is an HIV protease inhibitor that is used in the treatment of HIV-1 infection. This drug inhibits HIV-1 protease from binding and catalyzing by attaching to the enzyme and preventing HIV replication. Darunavir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Applications Atazanavir-8-(N-methoxycarbonyl)-L-tert-leucine Ester is an impurity of the drug Atazanavir (A790051). Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavir References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

Applications An intermediate for the synthesis of Atazanavir and the preparation of some peptide analogs. References Martin, J., et al.: Prog. Med. Chem., 32, 239 (1995), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998).

Ganoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities.

Anti-viral; HIV protease inhibitor

Applications Tenofovir (T018500) impurity. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005);

Impurity Lopinavir EP Impurity K Applications Lopinavir D-Valine Diastereomer (Lopinavir EP Impurity K) is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product. References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

8-epiAtazanavir is a stereoisomer of the antiretroviral drug Atazanavir, which is derived from synthetic sources. It acts as an HIV-1 protease inhibitor, where it binds to the active site of the viral protease enzyme, thereby preventing the cleavage of precursor proteins required for the maturation of infectious viral particles. This interference with viral replication is achieved by the structural mimicry of the natural substrate of the protease, allowing it to competitively inhibit the enzyme's activity. The applications of 8-epiAtazanavir are primarily in the field of HIV research, where it is utilized to investigate the stereochemistry and efficacy of protease inhibitors. Researchers may employ this compound in studies that assess the impact of stereochemistry on drug action and resistance profiles. Additionally, it provides insights into the design and development of novel therapeutics targeting viral proteases, contributing to the optimization of antiretroviral therapies. Its specific role as an isomer makes it a valuable tool in comparative analyses with the more widely used Atazanavir.

Voxilaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease.

Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product. References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)

Carbovir triphosphate triethylamine is a nucleotide analog, which is a derivative of nucleoside analogs designed for antiviral applications. It is synthesized through chemical modification of guanosine analogs, resulting in its active triphosphate form. This compound functions as a potent antiretroviral agent by mimicking natural nucleotides and interfering with viral DNA synthesis. The active triphosphate impedes the action of viral reverse transcriptase by incorporating itself into the viral DNA chain, causing premature termination and effectively halting viral replication. In scientific research, Carbovir triphosphate triethylamine is primarily explored for its efficacy against HIV-1. Its mechanism of action provides insights into developing therapeutic strategies to manage retroviral infections. The compound’s ability to inhibit viral replication makes it a valuable tool in the study of drug resistance mutations and antiviral drug development. Researchers focus on its pharmacokinetics, metabolic stability, and potential to overcome existing challenges in antiviral therapy. The detailed study of such compounds aids in the advancement of novel treatments and the enhancement of current antiviral regimens.

Applications (+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties. References Ganatra, S.H., et al.: J. Comp. Sys. Biol., 5, 68 (2012); Abaza, M.S. I., et al.: Tumor. Biol., 33, 1951 (2012); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Shishido, T., et al.: J. Virol., 86, 9055 (2012);

Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);

ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.

Impurity Ribavirin EP Impurity C Applications 1,2,4-Triazole-3-carboxylic Acid (Ribavirin EP Impurity C) is a major metabolite of the antiviral agent Ribavirin (R414475). References Miller, J.P. et al.: Ann. N.Y. Acad. Sci., 284, 211 (1977); Catlin, D. et al.: Ribavirin: Broad Spec. Antivir. Ag., 83 (1980); Lin, C.C. et al.: Antimicrob. Ag. Chemother., 50, 2368 (2006);

JNJ-49095397 (RV568) is a p38 MAPK-α and p38 MAPK-γ kinase inhibitor for the study of respiratory syncytial virus infection.

PI4KIII beta inhibitor

SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.

Zalcitabine (also known as dideoxycytidine or ddC) is a nucleoside analogue reverse transcriptase inhibitor (NRTI) medication used in the treatment of human immunodeficiency virus (HIV) infections. It works by blocking reverse transcriptase, an enzyme essential for replication of the HIV virus, thereby preventing the virus from multiplying and spreading. Zalcitabine is often used in combination with other antiretroviral drugs to effectively treat HIV/AIDS. Zalcitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL

Applications Labelled Pleconaril (P580350). Picornavirus replication inhibitor. Antiviral. References Kearns, G.L., J. Clin. Pharmacol., 39, 613 (1999), Schmidtke, M. et al.: Antiviral Res. 81, 56 (2009)

Applications 2-Fluoro-3-methoxyaniline is a reagent that is used in the structure-activity relationship studies on a series of cyclopentane-containing macrocyclic inhibitors of hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Raboisson, R., et al.: Bioorg. Med. Chem. Lett., 18, 4853 (2008)

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Applications An impurity of Tenofovir (T018500(P)). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Applications An intermediate in the synthesis of Ritonavir.

6'-O-Galloylsalidroside has antiviral activity and inhibits HIV.

MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits H1N1 virus strain high pathogenic avian influenza H5N1 virus strain.