Antiparasitics

Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.

UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).

Diethyltoluamide (DEET) is the most general active composition in insect repellents.

Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.

Nifuratel (SAP 113) is a local antiprotozoal and antifungal agent that may also be given orally.

Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence.

TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

Diloxanide furoate treats mild intestinal Amebiasis and is preferred for asymptomatic cyst carriers.

Applications Farnesal is a reagent in the synthesis of farnesylpyrophosphate analogues which acts as bisubstrate inhibitors of protein farnesyltransferase and has antiparasitics properties. References Duez, S. et al.: Bioorg. Med. Chem., 18, 543 (2010);

Compound 31 (compound 7k) is an orally active inhibitor of Plasmodium falciparum aspartic protease, plasmepsin X (PMX), with antimalarial properties [1].

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Applications 3-Hydroxy Niclosamide is a metabolite of Niclosamide(N395500) which is used as an anthelmintic drug (Cestodes). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Anti-malarial quinine analogue; effective against Covid-19 infection in vitro

Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.

Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Stability Hygroscopic, Temperature Sensitive Applications Ivermectin B1 Aglycon is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178

Fexinidazole, an antiparasitic, targets T. cruzi, T. foetus, T. vaginalis, E. histolytica, T. brucei, L. donovani. Active forms: sulfoxide, sulfone.

Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.

Pirimiphos-methyl: organophosphorus insecticide/acaricide; inhibits AChE; controls beetles, moths, weevils in stored grains.

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

CCOE-5 is a chalcone derivative with antimalarial activity, exhibiting an IC50 of 1.4 μg/mL against P. falciparum (3D7) and an IC50 of less than 5 μg/mL against P. falciparum (INDO). CCOE-5 shows potential for research in the anti-infective domain.

Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen

CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1, respectively.CpCDPK1/TgCDPK1-IN-2 can

Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and

Clopidol (WR-61112) is a very effective anticoccidial agent used in poultry.

Applications N-Didestethyl Chloroquine-d4 Phthalimide is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate, which is an antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product. References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),

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SpdSyn binder-1 weakly inhibits malaria by binding to Plasmodium falciparum's spermidine synthase. Used for research.

Applications The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product. References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite. The compound is primarily used to control a variety of parasitic worms and arthropods in both agricultural and veterinary contexts. Its specificity for invertebrate nerve cells over those of vertebrates makes it particularly effective with minimal toxicity to the host species. This precision in action helps maintain ecological balance while preserving host health. It is a critical tool in managing parasitic resistance, providing a reliable option for controlling infestations that are prone to adapt to other treatment strategies.

Antiparasitic Agent-20 (Compound 1p) exhibits broad-spectrum activity as a parasitic inhibitor, demonstrating efficacy against T.

Robenidine hydrochloride (Robenidine Hydrochoride) is an anticoccidial agent mainly used in poultry.

Decoquinate (Deccox) is a coccidiostat for poultry.

Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.

Compound 42 (Compound 2), an antimalarial agent, effectively inhibits Plasmodium falciparum during the asexual blood stages (IC 50 <0.5μM) and gametocytes (IC 50 is 0.14 μM).

Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial