Fatty Acids

Applications rac 1,2-Bis-palmitoyl-3-chloropropanediol-D5 was useful for establishing an analytical method for quantifying free and ester bound 2-​, 3-​MCPD, and esterified glycidol in fishery products. References Karl, H., et al.: Eur. J. Lipid Sci. Technol., 118, 406 (2016)

Applications Labelled lipids. New lipids in food protein hydrolyzates.

Stability Moisture Sensitive Applications Palmitoyl Chloride was used as a polymeric carriers for plasmid DNA (pDNA) delivery to 293T cells. References Remant, B.K.C., et al.: J. Biomaterials. Sci. Poly. Ed., 22, 873 (2011); Allard, E., et al.: Int. J. Pharma., 379, 217 (2009);

Propargyl chloride is a chemical that is used as an inhibitor in organic synthesis. It can be used to synthesize compounds with reactive groups such as alkenes, ketones, and amines. Propargyl chloride reacts with the hydroxyl group of an alcohol to form a propargyl alcohol. The reaction mechanism involves intramolecular hydrogen bonding between the hydroxyl group of the propargyl chloride and the carbon atom adjacent to it. Kinetic energy is required for this reaction to occur. The product of this reaction can then react with other molecules in order to form new compounds. Propargyl chloride has been shown to have therapeutic effects on chronic coughs due its ability to reduce the amount of kinetic energy needed for respiratory tract cells, which may have reduced coughing frequency. END>>

Applications 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester is used in the synthesis of antibacterials. References Phillips, O. et al.: Exp. Opin. Ther. Pat., 19, 529 (2009);

Clindamycin palmitate hydrochloride is an antimicrobial agent that has been used to treat infectious diseases, such as streptococcal pharyngitis. It binds to the 50S ribosomal subunit through a covalent linkage with the amino acid palmitate. The structural analysis of this drug has shown that it is a prodrug form of clindamycin, which is activated by hydrolysis in vivo. Clindamycin palmitate hydrochloride has been shown to be effective against Streptococcus pyogenes, and its efficacy may be due to the high affinity of clindamycin for binding to streptococci.