Steroids

Natural alkaloid

25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.

Applications Sitostanol-d7 is a compound useful in organic synthesis.

Impurity Clobetasol Propionate EP Impurity A / Betamethasone Dipropionate EP Impurity B Applications Betamethasone 17-Propionate (Clobetasol Propionate EP Impurity A) is a degradation product of Betamethasone. Glucocorticoid. References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

Applications Labelled Deoxycorticosterone. A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700). References Bohl, C., et al.: J. Med.Chem., 47, 3765 (2004), Smith, J., et al.: Steroids, 73, 1160 (2008),

2,3-Didehydrosomnifericin is a compound isolated from Pteris oleifera, a plant of the Solanaceae family.

Impurity Cyproterone Acetate EP Impurity F Applications Cyproterone (Cyproterone Acetate EP Impurity F) is an antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals. References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications A labelled anabolic steroid.Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

Stability Hygroscopic Applications Glycocholic Acid Sodium Salt is a biochemical formed by the conjugation of cholic acid (C432600) with glycine (G615990). References Monalisa, M., et al.: Langmuir, 27 (2011);

Ophiopogonin D is a steroidal glycoside, which is a secondary metabolite sourced from the plant Ophiopogon japonicus. This compound is characterized by its presence in the roots, commonly referred to as radix Ophiopogonis, and is part of the broader group of ophiopogonins. Its mode of action primarily involves exerting anti-inflammatory and antioxidant effects. Ophiopogonin D has been shown to modulate signaling pathways that influence cellular oxidative stress and inflammatory responses, which are key in various pathological conditions. The uses and applications of Ophiopogonin D are diverse, extending to both traditional and modern pharmacological contexts. In traditional Chinese medicine, this compound is utilized for its purported benefits in cardiovascular health and respiratory functions. In contemporary research, Ophiopogonin D is being investigated for its potential neuroprotective effects and its role in modulating glucose metabolism, with implications for treating neurodegenerative diseases and diabetes. Its multifunctional properties make it a subject of interest for developing novel therapeutic agents targeting oxidative and inflammatory pathways.

Impurity Rocuronium EP Impurity A Applications (2β,3α,5α,16β,17β)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane (Rocuronium EP Impurity A) is a compound is used in the synthesis of the neuromuscular blocking agent rocuronium bromide. References Srinivasan, N. et al.: Orient. J. Chem., 24, 989 (2008);

1. Pseudoprotodioscin has moderate cytotoxicity.

Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.

Coumestrol is a phytoestrogen compound, which is a naturally occurring compound found in a variety of plants, such as soybeans, clover, and alfalfa. It is derived from the metabolic processes within these plants. Coumestrol exhibits estrogenic activity, acting as an agonist for estrogen receptors. This biological activity enables coumestrol to mimic the action of endogenous estrogens, thereby influencing estrogen-responsive pathways. Researchers extensively study coumestrol for its potential effects on human health, particularly in understanding estrogenic impact in various physiological processes. It is of interest in exploring alternatives to hormone replacement therapies and in cancer research, especially concerning breast and prostate cancers. Due to its ability to interact with estrogen receptors, there is significant interest in understanding how it may modulate hormonal balances and contribute to health outcomes in both preclinical and clinical settings.

Applications Epoxy Metradiene is an impurity from synthesis of Fluorometholone (F593145),a glucocorticoid; anti-inflammatory. References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982); Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984);

Applications Melengestrol Acetate derivative, an orally active progestational steroid. References Patton, M., et al.: Zoo Biol., 26, 311(2007), Sellin, M., et al.: Environ. Toxicol. Chem., 28, 2443 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Sanseverino, J., et al.: Toxicol. Sci., 107, 122 (2009),

Natural glycoside

Pregnenolone is a steroidal hormone precursor, which is synthesized from cholesterol in the mitochondria of adrenal glands and other tissues. Its mode of action involves serving as a precursor for other critical steroid hormones, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As a neurosteroid, it plays a significant role in modulating synaptic function and neurogenesis. Pregnenolone is utilized in research to understand hormone synthesis pathways and its effects on cognitive functions, memory enhancement, and neuroprotection. It is involved in studies focusing on stress response, aging, and neurological conditions such as Alzheimer's disease, due to its impact on neuroplasticity and cell signaling pathways. It is also being examined for its potential role in mood regulation and the modulation of inflammatory processes.

Lactone

Taurochenodeoxycholate-3-sulfate (TCDCS) is a top-ranking classifier on the receiver operating characteristic curve for severe and non-severe COVID-19 patients.

Dihydrowithaferin A, a withanolide from Withania somnifera, inhibits AChE and may reduce tumor growth.

Applications Metabolite of 5α-Androst-16-en-3β-ol References Gower, D., et al.: J. Steroid Biochem. Mol. Biol., 63, 81 (1997), Zorko, M., et al.: Steroids, 65, 46 (2000), Diel, P., et al.: Toxicol. Lett., 169, 64 (2007),

Sterol

Applications A labelled metabolite of 17β-Estradiol. References Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995), D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1994), Forsis, T., et al.: Nature, 368, 237 (1994)

Applications Testosterone Palmitate-d31 is the labeled analogue of Testosterone Palmitate (T155140) which is found in male serum. References Addo, S.B., et. al.: Steroid, 54, 257 (1989)

Natural glycoside

Applications 4-Hydroxytestosterone is an anabolic steroid and does not have any therapeutic indication. 4-Hydroxytestosterone is metabolite of the aromatase inhibitor Formestane (F692250). 4-Hydroxytestosterone concentration in the urine can be used as a biomarker for steroid misuse.Controlled Substance. References Kohler, M. et al.: Steroids, 72, 278 (2007); Brodie, A.M. et al.: J. Steroid. Biochem., 14, 693 (1981); Van Renterghem, P. et al.: Steroids, 75, 154 (2010);

Impurity Rocuronium EP Impurity H Stability Hygroscopic Applications 1,2-Dehydro-3-oxo Rocuronium Bromide (Rocuronium EP Impurity H) is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker. References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)

Applications A biologically active metabolite of Desogestrel. References Croxatto, H.B., et al.: Hum. Reprod., 14, 976 (1999), Edwards, J.E., et al.: Brit. J. Fam. Plan., 24, 3 (1999),

Applications Labelled Deoxycorticosterone. A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700). References Bohl, C., et al.: J. Med.Chem., 47, 3765 (2004), Smith, J., et al.: Steroids, 73, 1160 (2008),

Applications Cholesterol-d6 has been used in safe procedures to measure the percentage of cholesterol absorption, based on that of D. B. Zilversmit (1972), by using Cholesterol-d6 as a stable nonradioactive isotopic tracer of cholesterol that was administered orally into normal individuals to facilitate clinical investigation. References Bosner, Matthew S., Journal of Lipid Research, 34, 1047-53, (1993)