Steroids

Stability Hygroscopic Applications A metabolite of Triamcinolone acetonide. References Edsbacker, S., et al.: Drug Metab. Dispos., 11, 590 (1983), Szefler, S., et al.: Eur. J. Clin. Pharmacol., 30, 323 (1986), Hansel, T., et al.: J. Immunol. Methods, 145, 105 (1991), Argenti, D., et al.: J. Clin. Pharmacol., 39, 695 (1999),

Natural glycoside

Applications Labelled Choleretic. References Mills, K.A., et al.: Pedatric Research, 43, 3 (1998)

Stability Hygroscopic Applications Cholenoic acid present in significant proportions during early gastation. References Setchell, K., et al.: J. Biol. Chem. 263, 16637 (1988), Nakagawa, M., et al.: J. Lipid Res., 31, 1089 (1990),

Saponin C from Liriope muscari can be extracted from Liriope muscari, family Liliaceae.

Sterol

3,9-Di-O-methylcoumestrol is a phytoestrogen that is structurally similar to the human estrogen. It has been shown to have a protective effect on fertility in rats with ovariectomized. 3,9-Di-O-methylcoumestrol has been shown to increase the number of oocytes and decrease the number of follicles in rats treated with proton radiation. This compound also has an effect on UV absorption and can be used as an indicator for UV exposure. In addition, 3,9-Di-O-methylcoumestrol has been found to have different effects on ecotypes and dianions.

Applications A labelled metabolite of Equilin (E592800). References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),

Applications A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor. References Weiss, G., et al.: J. Clin. Endocrinol. Metab., 43, 696 (1976), Hirschmann R., et al.: Steroids, 57, 579 (1992),

Oxygen-heterocyclic compound

Tetracosactide, a synthetic peptide, mirrors the 24-amino acid start of ACTH with sequence SYSMEHFRWGKPVGKKRRPVKVYP.

Applications It has been used in combinations as an oral contraceptive. References Brennan, D.M., et al.: Acta Endocrinol., 44, 367 (1963), Honma., s., et al.: Chem Pharm. Bull., 25 2019 (1977), Usui, T., et al.: Acta Urol. Jpn., 27, 327 (1981),

Applications The main metabolite of 3,4-methylenedioxymethamphetamine (MDMA) (M303985). References Lin, L., et al.: Drug Metab. Dispos., 25, 1059 (1997), Kreth, K., et al.: Biochem. Pharmacol., 59, 1563 (2000), Shima, N., et al.: Xenobiotica, 36, 259 ( 2006),

Lactone

Stability Hygroscopic Applications A degradation product of Betamethasone (B327000). References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

Periplogenin is a compound classified as a cardiac glycoside, which is typically derived from certain plant species such as those in the Apocynaceae family. These compounds are known for affecting the heart by influencing cellular ion transport mechanisms. The primary mode of action of periplogenin involves inhibition of the Na⁺/K⁺-ATPase pump. This inhibition leads to an increased intracellular concentration of sodium ions, which indirectly increases intracellular calcium levels via the sodium-calcium exchanger. The elevated calcium concentration enhances cardiac muscle contractility, a mechanism often leveraged in treating certain heart conditions. In scientific research, periplogenin's potential therapeutic applications extend to its use in studying cardiac physiology and pharmacology, particularly in contexts of heart failure and atrial fibrillation. Its profound effects on ion regulation and heart muscle contractility make it a compound of interest for developing novel treatments and understanding more about heart function. Furthermore, exploring its bioactivity could provide insights into potential anti-cancer properties due to its ability to modulate cellular ionic environments.

Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7).

Reduced form of lanosterone

Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.

Impurity Beclomethasone Dipropionate EP Impurity E Applications 6α-Chlorobeclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity E) is an analogue of Beclomethasone Dipropionate (B131030), an antiallergic, antiasthmatic (inhalate). Anti-inflammatory (topical). References Laube, B., et al.: J. Allergy Clin. Immunol., 101, 475 (1998); Harrison, L., et al.: Eur. J. Clin. Pharmacol., 58, 191 (2002); Maneechotesuwan, K., et al.: J. Allergy Clin. Immunol., 121, 43 (2008)

Applications Isotope labelled Ethynyl Estradiol (E685100), an oral contraceptive (1), is a synthetic steroid with high oral estrogenic potency. Used in estrogen replacement therapy (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.

Impurity Rocuronium EP Impurity E Stability Hygroscopic Applications 2-Pyrrolidinyl desmorpholinylrocuronium Bromide (Rocuronium EP Impurity E) is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker. References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)

Applications Cholesteryl Decanoate-d3 is the labeled analogue of Cholesteryl Decanoate (C432535), a lubricant additive used to improve the performance of lubricants. References Pavlov, A.S., et. al.: Zavodskaya Laboratoriya, Diagnostika Materialov, 77, 55 (2011)

Applications A systematic corticosteroid. Anti-inflammatory. References Mroszczak, E.J. et al.: J. Pharmac. Sci., 67, 920 (1978); Moellmann, H. et al.: Int. J. Clin. Pharmacol. Therap., 34, 1 (1996);

Applications A metabolite of Etiocholanolone. References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),

Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.

Applications A metabolite of Mifepristone. References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Applications It is one of the main metabolite of Stanozolol (S684500), an internal standard in doping analysis. References Chung, B., et al.: J. Anal. Toxicol., 14, 91 (1990), Schanzer, W., et al.: J. Steroid Biochem., 36, 153 (1990), Phillis, B., et al.: Eur. J. Pharmacol., 398, 263 (2000),

Timosaponin BII combats dementia, treats type 2 diabetes, has antioxidant properties, and reduces BACE1 with retinal benefits.

Applications Triamcinolone Acetonide-d6 is the labeled analogue of Triamcinolone Acetonide (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982)

Sterol

Campesterol is a plant sterol that lowers cholesterol, has anti-cancer and anti-inflammatory properties, and can help with specific prostate conditions.

Applications Anabolic steroid. References Musshoff, F., et al.: J. For. Sci., 42, 1119 (1997), Pagonis, T., et al.: Clin. Toxicol., 46, 57 (2008), Sartorio, A., et al.: Eur. J. Endocrinol., 150, 511 (2004),

Dioscin is a steroidal saponin, which is a naturally occurring compound found in various plants, notably in species such as Dioscorea nipponica and Dioscorea zingiberensis. These plants belong to the yam family, which are well-regarded for their medicinal properties. The mode of action of dioscin involves modulation of various biochemical pathways, including the suppression of inflammatory cytokines and inhibition of cancer cell proliferation. Additionally, dioscin has been shown to promote apoptosis in cancer cells through the activation of caspases and disruption of mitochondrial function. Dioscin is utilized in scientific and medical research for its potential therapeutic effects. Its anti-inflammatory properties make it a candidate for studying treatments for conditions such as arthritis and other inflammatory diseases. Furthermore, its anticancer activity is of interest in the development of treatments for various types of cancer, exploring its ability to induce cancer cell death while sparing normal cells. Additional research is ongoing to better understand the full range of its pharmacological effects and potential applications in medicine.

Applications An impurity of Dexamethasone (D298800), Desoxymethasone, Fluocortolone (F500500) and Diflucortolone. References Dekker, D., et al.: 5, 195 (1980),

Impurity Betamethasone Dipropionate EP Impurity G Applications Betamethasone Tripropionate (Betamethasone Dipropionate EP Impurity G) is a Betamethasone (B327000) related compound. References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Chen, B., et al.: Steriods, 74, 30 (2009), Mikami, E., et al.: J. Pharm. Biomed. Anal., 28, 261 (2002),

Testosterone phenylpropionate (Testosterone 17-phenylpropionate)is a steroid indicated for testosterone replacement therapy in sterilization, missing testicle,

Applications A labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. References Brindle, J., et al.: Nat. Med., 12, 1439 (2002), Lindon, J., et al.: Biomarkers, 9, 1 (2004), Holmes, E., et al.: Cell, 134, 714 (2008),

Stability Hygroscopic Applications The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. References Ho, R., et al.: J. Biol. Chem., 279, 7213 (2004), Pasanen, M., et al.: Eur. J. Clin. Pharmacol., 62, 409 (2006), He, Y., et al.: Drug Metab. Dispos., 36, 1453 (2008),

Applications A metabolite of Desoxymetasone (D296970). References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),