Steroids

Stability Moisture Sensitive Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);

Impurity Fluocinolone Acetonide EP Impurity D Stability Hygroscopic Applications Fluocinolone acetonide-21-aldehyde, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching. References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications 17α-Boldenone (B675105) derivative.

Androsta-1,4,6-triene-3,17-dione is a steroidal aromatase inhibitor, which is a synthetic compound derived from modifications of naturally occurring steroid structures. Its mode of action involves the inhibition of the aromatase enzyme. Aromatase catalyzes the conversion of androgens into estrogens, a critical step in the biosynthesis of estrogens. By inhibiting this enzyme, Androsta-1,4,6-triene-3,17-dione effectively reduces estrogen levels, which can be of particular interest in research environments exploring the role of estrogens in various biological processes. This compound is primarily used in the context of endocrine research, where understanding the modulation of hormone levels is crucial. It can be employed in studies investigating the mechanisms of hormone-dependent cancers, such as breast cancer, where estrogen plays a significant role in tumor progression. Additionally, its use extends to research involving metabolic disorders, bone density, and estrogen's wider physiological impacts. Due to its potent inhibitory action on aromatase, Androsta-1,4,6-triene-3,17-dione serves as a valuable tool for scientists aiming to elucidate complex hormonal pathways and their implications in health and disease.

Applications 3-Isopropenyl-2-oxo-1-benzimidazolinebutyric Acid Ethyl Ester (cas# 116199-87-2) is a compound useful in organic synthesis.

Applications A labelled metabolite of Cortisol. References Dossing, M., et al.: Eur. J. Clin. Pharmacol., 25, 215 ( 1983), Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Raucy, J., et al.: Drug Metab. Dispos., 31, 533 (2003), Pal, D., et al.: Life Sci., 78, 2131 (2006),

Saponin from the quillaja plant is a natural extract characterized by a significant sapogenin content of 25%-30%. This product is derived from the bark of the Quillaja saponaria tree, a native species of Chile. The primary mode of action of these saponins involves the interaction with cell membranes due to their surfactant properties, which can lead to membrane permeabilization and subsequent cellular responses. Saponins are widely used across various scientific fields. In biochemistry, they serve as adjuvants for vaccine formulations due to their ability to enhance the immune response. In pharmaceuticals, saponins' properties are leveraged for their potential anti-inflammatory and cholesterol-lowering effects. Additionally, in agricultural sciences, they are utilized as natural pesticides or growth promoters. Their amphiphilic nature also makes them useful in food and cosmetic formulations as emulsifiers. Saponins' diverse applications stem from their unique ability to modulate biological membranes, making them a valuable tool in a range of experimental and applied research contexts.

Paniculoside I(FS-8855) is an iridoid glucoside from Pseudocaryopteris paniculata(CB Clarke)PD Cantino.Cost-effective and quality-assured.

Equilenin is a steroidal estrogen, which is a type of naturally occurring hormone. It is derived primarily from the urine of pregnant mares and belongs to the class of conjugated equine estrogens. In terms of its mode of action, equilenin functions by binding to estrogen receptors in various tissues, thereby modulating gene expression and influencing cellular activity. This interaction supports the management of estrogen deficiencies in postmenopausal women and can influence the regulation of certain metabolic processes. Equilenin is prominently used in hormone replacement therapies aimed at alleviating symptoms associated with menopause, such as hot flashes, osteoporosis, and vaginal atrophy. Its application is crucial in maintaining the overall quality of life in affected patients. Due to its biological origin and specific receptor interactions, equilenin continues to be a subject of study for its potential roles in various therapeutic protocols beyond menopausal symptom relief, including potential protective effects on bone density and cardiovascular health.

Applications Pregnenolone-d6 is the labeled analogue of Pregnenolone (P712200), a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. References Bjondahl, K., et al.: Med. Biol., 54, 454 (1976); Geick, A., et al.: J. Biol. Chem., 276, 14581 (2001); Johnson, D., et al.: Toxicol. Sci., 66, 16 (2002); Abe, C., et al.: Lipids, 42, 637 (2007)

Calciferol is a strong inhibitory effect against bladder tumor promotion by sodium saccharin and induces cell differentiation in leukemia cells. Calciferol also been shown to be an inhibitor of DNA polymerase. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Impurity Fluticasone EP Impurity G Applications Fluticasone Dimer Impurity (Fluticasone EP Impurity G) is a dimeric impurity of Fluticasone Propionate (F599500). References Mistry, N. et al.: J. Pharmac. Biomed. Anal., 19, 511 (1999);

Applications Synthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid). References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976), Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977),

Adynerigenin beta-neritrioside (Adynerin gentiobioside) is a trisaccharide glycoside isolated from oleander leaves.

Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Natural glycoside

Stability Light Sensitive, Temperature Sensitive Applications An oxidized derivative of the visual pigment carotenoid. References Wada, A., et al.: Chem. Pharm. Bull., 56, 112 (2008), Smolensky, E., et al.: Biochem., 48, 9170 (2009),

4-Cholesten-3-one is used as a chiral building block for proteomics research. It is an intestinal metabolite of cholesterol and exhibits an anti-obesity effect on animals. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking. References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)

Applications 5β-Dihydro Progesterone-d8 is labelled which is labelled 5β-Dihydro Progesterone (D449280), a metabolite of the neuroactive steroid Progesterone (PROG) (P755900). References Wiebe, J., et al.: Cancer Res., 60, 936 (2000), Lacasa, D., et al.: J. Biol. Chem., 276, 11512 (2001), Johansson, I., et al.: Brain Res., 934, 125 (2002), Leonhardt, S., et al.: Steroids, 68, 761 (2003),

Natural alkaloid

Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),

Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.

**Azedarachol** is a botanical compound, which is a natural product derived from the neem tree (Azadirachta indica). This compound is known for its role as a bioactive agent, working through mechanisms that involve disrupting insect endocrine systems and acting as an antifeedant. Azedarachol's mode of action is primarily through its interference with hormonal balance within target organisms, which can lead to decreased feeding, stunted growth, and interrupted reproduction, making it an area of interest for pest control research. Azedarachol's applications span both agricultural and medicinal fields. In agriculture, the compound is being studied for its potential use as an eco-friendly alternative to synthetic pesticides. Its ability to selectively target pest species while minimizing impact on beneficial insects makes it a viable candidate for integrated pest management strategies. Additionally, research into its pharmacological properties is ongoing, with investigations into its anti-inflammatory and antimicrobial effects, which may broaden its use in developing new therapeutic agents. By understanding and harnessing the multifaceted actions of Azedarachol, scientists aim to contribute to sustainable practices in both agriculture and medicine.

Lactulose (Lactulosum) , a synthetic disaccharide , is used in the treatment of constipation and hepatic encephalopathy.

Applications A labelled progestogen with low androgenic potency. References Viinikka, L., et al.: Eur. J. Clin. Pharmacol., 15, 349 (1979), Bergink, E.W., et al.: J. Steroid Biochem., 14, 175 (1981)

Chlorogenin is a natural steroid derived from the herbs of Agave americana.

Applications Trenbolone Enanthate is an analog of Trenbolone (T719000), a controlled substance (anabolic steroid). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Natural alkaloid

Sterol

Pseudoprotodioscin is a bioactive saponin compound, which is primarily derived from various plant sources, including members of the genus Tribulus. The compound is part of a larger family of steroidal saponins known for their diverse biological activities. Its mode of action includes influencing cellular pathways through modulation of enzyme activity and interaction with steroid hormone receptors, contributing to its bioactivity. Pseudoprotodioscin is studied for its potential therapeutic applications, particularly in the fields of oncology and endocrinology, due to its ability to exhibit anti-cancer, anti-inflammatory, and aphrodisiac properties. It has been shown to inhibit cell proliferation in certain cancer cell lines, suggesting its utility in developing anti-cancer therapies. Additionally, it may have beneficial effects on testosterone levels and has been explored for improving sexual health. The ongoing research into its mechanisms and applications continues to uncover the vast potential of this compound in pharmaceutical development.

Ent-Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-ent-fisetinidol is a complex flavan-3-ol oligomer, which is a type of polyphenolic compound commonly found in various plant species. This compound is derived primarily from plants such as those in the genus *Acacia* and other similar species rich in condensed tannins. The mode of action of this oligomer involves its ability to engage in antioxidant activities, which include scavenging free radicals and chelating metal ions that facilitate oxidative stress in biological systems. The uses and applications of ent-Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-ent-fisetinidol are primarily in the realm of research focused on understanding its bioactive properties in vitro and in vivo. Its potential antioxidant effects make it a compound of interest in the study of oxidative stress-related conditions, such as cardiovascular diseases, inflammation, and neurodegenerative disorders. Additionally, it may play a role in the development of natural product-based therapeutics aimed at mitigating oxidative damage or improving overall health through its free radical scavenging capabilities. Investigating its precise mechanisms and potential therapeutic indices continues to be an active area of scientific inquiry.