Steroids

Applications An anabolic steroid.Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

25-Hydroxycholesterol, a steroid, hinders SREBPs cleavage and HMG-CoA, regulating cholesterol synthesis and suppressing IgA in B cells. EC50≈65 nM.

Pseudoprotodioscin exhibits anti-inflammatory and anticancer activities, it shows a weaker suppressing effect on the production of inflammatory cytokines, and can suppress melanogenesis in B16F1 cells.

Applications Progesterone with antiestrogen and antiandrogen activity. References Brown-Grant, K., et al.: J. Endocrinol., 38, 145 (1967), Ferraresi, R., et al.: J. Allergy Clin. Immunol., 55, 25 (1975),

Applications N-Desmethyl Ulipristal Acetate-d3, is the labeled analogue of N-Desmethyl Ulipristal Acetate (D296005), which has been shown to contribute significantly to the antiprogestational activity of its parent compound. References Attardi, B.J. et al.: J. Steroid Biochem. Mol. Biol., 88, 277 (2004);

Applications A labelled orticosteroid prodrug for the treatment of eye disorders. References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),

Impurity Fusidic Acid EP Impurity H Applications 11-Keto Fusidic Acid (Fusidic Acid EP Impurity H) is a metabolite of Fusidic Acid. References Godtfredsen, W.O., et al.: J. Med. Chem., 9, 15 (1966), Perry, M.J., et al.: J. Antibiot., 36, 1659 (1983),

Applications A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lands, M., et al.: J. Pharmacol. Exp. Ther., 89, 382 (1947), Repke, D.B., et al.: J. Pharm. Sci., 67, 1167 (1978), Pope, H.G., et al.: J. Clin. Psychiatry, 47, 339 (1986), Cho, A.K., et al.: Science, 249, 631 (1990),

Applications 9-Nor-5-androstene-3β,17β-diol is a synthetic anabolic steroid that interacts with androgen receptors. 9-Nor-5-androstene-3β,17β-diol has been studied as a new C19-steroidal androgen receptor modulators for potential treatment of prostate cancer. References Marwah, P., et al. Bioorg. Med. Chem., 14, 5933 (2006); Cunningham, G.R., et al.: Steroids., 38, 243 (1981);

Impurity Fluocinolone Acetonide EP Impurity G Applications Flurandrenolone Acetate, is the derivative of Flurandrenolide (F598650), which is a Glucocorticoid, used as an antipsoriatic. References Pearlman, R., et al.: Int. J. Pharm., 18, 53 (1984), Neufeld, E., et al.: J. Chromatogr., 718, 273 (1998),

Applications Methenolone is an anabolic steroid. This is a controlled substance. References Schiffer, M., et al.: J. Clin. Invest., 108, 807 (2001), Okuyama, S., et al.: Clin. Nephrol., 68, 412 (2007), Sjoqvist, F., et al.: Lancet, 371, 1872 (2008),

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.

Applications Used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus. References Miyachi, Y., et al.: Br. J. Dermatol., 114, 231 (1986), Rallis, E., et al.: Drugs Exp. Clin. Res., 30, 191 (2004), Ozcan, H., et al.: Eur. J. Dermatol., 17, 313 (2007),

Applications 1,2,4,5-Tetrahydrotestolactone is a steroid with estrogenic properties. A steroid lactone. References Pollard, I., et al.: Steroids, 11, 897 (1968), Volovel'skii, L. N., et al.: Zh. Obshch. Khim., 43, 1414 (1973)

Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine.

Applications A metabolite of 3,4-methylenedioxyethylamphetamine (M303975). References Nichols, D., et al.: J. Med. Chem., 29, 2009 (1986), Ricaurte, G., et al.: Brain Res., 446, 165 (1988), Colado, M., et al.: Br. J. Pharmacol., 111, 131 (1994), Helmlin, H., et al.: J. Anal. Toxicol., 20, 432 (1996), Maurer, H., et al.: Ther. Drug Monit., 18, 465 (1996),

Applications 4-Androsten-17alpha-ol-3-one-2,2,4,6,6-d5 (CAS# 165195-35-7) is a useful isotopically labeled research compound.

Applications Boldenone is an anabolic steroid. Controlled substance. References Watanabe, K., et al.: J. Appl. Bacteriol., 62, 151 (1987), Liu, W., et al.: J. Ind. Microbiol., 13, 167 (1994), Barthakur, S., et al.: J. Basic Microbiol., 36, 383 (1996), Grinenko, G., et al.: Pharmaceut. Chem. J., 36, 510 (2002), de Brabander, H., et al.: Food Addit. Contam., 21, 515 (2004),

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Pseudobufarenogin(ψ-bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. ψ-Bufarenogin shows inhibition of human kidney Na(+)/K(+)-ATPase activity.

Applications Labelled Medroxyprogesterone (M203560). Progestogen; an injectable contraceptive. References Tang, M., et al.: Endocrinol., 151, 1320 (2010), Lee, K., et al.: Mol. Cell. Endocrinol., 319, 109 (2010), Rodgers, A., et al.: Chem., Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Applications Labelled Glycochenodeoxycholic Acid 3-Sulfate (G641270). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Applications 23-Hydroxybudesonide is an metabolite of budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent. References Edsbaecker, S., et al.: Drug. Metabol. Dispostion., 15, 403 (1987); Moore, C.D., et al.: Drug. Metabolism. Disposition., 41, 379 (2013);

Cholesteryl Acetate is a cholesterol ester obtained from the esterification of the hydroxyl group of cholesterol with acetic acid.

Digitalis glycoside

Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.

Pregnenolone acetate is a synthetic compound classified as a steroidal hormone precursor. It is derived from pregnenolone, which is a naturally occurring steroid hormone in the body. Pregnenolone is primarily synthesized from cholesterol, a fundamental component upon which steroidogenesis is based. The acetate form is an ester derivative, which can enhance stability and bioavailability. Pregnenolone acetate acts by serving as a precursor in the biosynthetic pathway of various steroid hormones, including progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. This mode of action makes it a critical intermediary in endocrine processes, impacting numerous physiological functions. The applications of pregnenolone acetate are primarily associated with its role in research and clinical studies focused on its potential effects on neurological and hormonal health. Researchers explore its influence on cognitive functions, stress response, immune modulation, and its prospects in addressing endocrine disorders. Its precise utility in experimental settings adds to the understanding of steroidal hormone pathways and their broader implications on health and disease management.

Oxygen-heterocyclic compound

Natural glycoside