Steroids

Applications (+)-20-Hydroxyecdysone regulates gene transcription via a genomic pathway through a transcription complex that is formed. References Liu, W. et al.: Endocrinol., 155, 1738 (2014); Wang, Q. et al.: Plant Physiol. Biochem., 84, 1 (2014);

Glycocholic acid (Glycocholate) is a bile acid with anticancer activity.

7 Beta-Hydroxycholesterol (7β-Hydroxycholesterol) is an oxidative stress inducer that promotes atherosclerosis.

Applications A new labelled metabolite of 17α-Methyltestosterone (M326400). References Blokland, M., et al.: Anal. Chim. Acta, 529, 317 (2005), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Pozo, O.J., et al.: Drug Metab. Dispos., 37, 2153 (2009),

Applications Controlled substance (anabolic steroid). A prohormone of Trenbolone (T719000). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Please enquire for more information about Teasterone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Hygroscopic Applications Active metabolite of Beclomethasone Dipropionate (BDP). References Soria, I., et al.: Biopharm. Drug Dispos., 19, 297 (1998), Harrison, L., et al., J. Pharm. Pharmacol., 51, 1235 (1999), Daley-Yates, P., et al.: Br. J. Clin. Pharm., 51, 400 (2001).

Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),

Applications Prostanozol (P838700) derivative.

Natural glycoside

Applications A metabolite of Finasteride (F342000) in human bile (M2 metabolite). References Faller, B., et al.: Biochemistry, 32, 5705 (1993), Carlin, J.R., Drug Metab. Dispos., 25, 100 (1997), Bergman, E., et al.: Eur. J. Pharm. Sci., 29, 205 (2006),

Applications Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic. References Sadee, W., et al.: J. Pharm. Sci., 61, 1126 (1972), Peterfalvi, M., et al.: Biochem. Pharmacol., 29, 353 (1980), Los, L., et al.: Drug Metab. Dispos., 21, 1086 (1993), Ter Heine, R., et al.: J. Pharm. Biomed. Anal., 49, 451 (2009),

Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.

Oxygen-heterocyclic compound

Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis. References ukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).

Testosterone-impurity K is a chemical compound that belongs to the category of impurities identified during the synthesis and formulation of testosterone-related pharmaceuticals. It is typically sourced from the by-products of testosterone synthesis and is crucial for ensuring the purity and efficacy of the final testosterone product. The mode of action of Testosterone-impurity K primarily involves serving as a reference standard or analytical benchmark to identify and quantify impurities present in testosterone preparations. The presence of impurities like Testosterone-impurity K is critically evaluated during quality control processes in the pharmaceutical industry. This compound is used extensively in analytical chemistry and pharmaceutical research to validate and refine the production process of testosterone medications, ensuring that the final products meet stringent safety and efficacy standards. Its analysis is pivotal in the development of high-precision analytical methods, contributing to the overall integrity and reliability of hormone-based therapies.

Natural glycoside

Applications Boldenone Propionate is a metabolite of Boldenone (B675100), which is an anabolic steroid. References Watanabe, K., et al.: J. Appl. Bacteriol., 62, 151 (1987) ; Liu, W., et al.: J. Ind. Microbiol., 13, 167 (1994) ; Barthakur, S., et al.: J. Basic Microbiol., 36, 383 (1996); Grinenko, G., et al.: Pharmaceut. Chem. J., 36, 510 (2002) ; de Brabander, H., et al.: Food Addit. Contam., 21, 515 (2004); Le Bizec, B., et al.: Steroids, 71, 1078 (2006);

Protodioscin has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. It appears to possess aphrodisiac activity probably due to its androgen increasing property, it will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.

Applications Quillaic Acid an unglycosylated saponin from the Quillaja saponaria bark is used as a topical antiinflammatory. References Arrau, S. et al.: J. Ethnopharm., 133, 164 (2011);

Betamethasone 21-phosphate disodium is a synthetic glucocorticoid, which is a man-made analog of naturally occurring steroid hormones produced in the adrenal cortex. Its molecular structure allows for enhanced potency and solubility, making it highly effective for use in various clinical settings. As a glucocorticoid, Betamethasone 21-phosphate disodium functions by binding to glucocorticoid receptors, regulating the expression of anti-inflammatory proteins, and inhibiting the production of pro-inflammatory cytokines. This mechanism of action reduces inflammation and suppresses the immune response, making it valuable in the treatment of conditions that involve excessive inflammation. It is commonly used in the management of conditions such as allergic reactions, certain types of arthritis, and skin diseases. Its ability to rapidly modulate inflammatory pathways also makes it useful in emergency settings for conditions like acute asthma exacerbations and severe allergic reactions. As a water-soluble ester, it allows for diverse administration routes, including oral, intravenous, and topical applications, depending on the clinical requirement.

Natural alkaloid

Stability Hygroscopic Applications A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Applications 1α-Methyl-5α-androstan-3α,17β-diol is an metabolite of anabolic androgenic steroid, testosterone (T155000). 1α-Methyl-5α-androstan-3α,17β-diol is also the methylated analogue of 5α-Androstane-3β,17β-diol (A637526). References Monetti, G., et al.: J. Steroid Biochem., 25, 765 (1986); Gragkaki, A.G., et al.: J. Steroid. Biochem. Molec. Biol., 115, 44 (2009); De Boer, D., et al.: J. Steroids. Biochem. Molec. Biol., 42, 411 (1992);

Applications A bile acid with hemolytic properties. Inhibits the initiation of Clostridium difficile spore germination. Anti-inflamatiory activity. References Segal, R. et al.; Life Sci. 10, 685 (1971); Sorg, J. et al.; J. Bacteriol. 192, 4983 (2010). Yasukawa, K. et al.; J. Pharm. Pharmacol. 61, 1051 (2009)

Applications 7,8-Didehydrocholesterol Acetate is an intermediate in the synthesis of Zymostenol, which is the derivative of Zymosterol (Z701520), an sterol intermediate in the biosynthesis of cholesterol (C432501). References Roland, E.D., et al.: J. Am. Chem. Soc., 111, 278 (1989); Echevarria, F., et al.: J. Biol. Chem., 265, 8484 (1990); Baranovskii, A.V., et al.: Russian. J. Bioorg. Chem., 28, 250 (2002); Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934);

Impurity Clobetasol Propionate EP Impurity K / Betamethasone Dipropionate EP Impurity C Applications Betamethasone 21-Propionate (Clobetasol Propionate EP Impurity K) is a degradation product of Betamethasone. Glucocorticoid. References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells.

"Gitogenin, tigogenin, and solasodine selectively inhibit UGT1A4. Gitogenin also stimulates growth hormone release and inhibits α-glucosidase."