Steroids

Applications A labelled metabolite of the synthetic anabolic steroid Norethandrolone (N675000).Controlled substance. References Nambara, T., et al.: Chem. Pharm. Bull., 21, 2474 (1973), Dumasia, M., et al.: Xenobiotica, 14, 647 (1984), Bi, H., et al.: J. Steroid Biochem. Mol. Biol., 42, 533 (1992),

Ergosterol peroxide (NSC 31324) is a derivative from mushroom with anti-tumor, pro-apoptotic anti-mycobacterial and anti-proliferative activities.

7-Ketocholesterol is a metabolite of Cholesterol

Applications Labelled Pregnanetriol, a steroid present at elevated levels in the urine of patients with congenital adrenal hyperplasma. During treatment with cortisol replacement, elevated urine Pregnanetriol levels indicate insufficient dosage of cortisol. Pregnanetriol is also one of the urinary marker for adrenal incidentaloma. Pregnanetriol is a metabolite of Androstenedione (A637550). References Kinoshita, K. et al.: J. Clin. Endocrinol., 26, 1219 (1966); Kotlowska, A. et al.: Clin. Biochem., 42, 448 (2009); Wang, J. et al.: Zhipu Xue., 25, 201 (2004);

Stability Hygroscopic Applications A metabolite of Cortisol (H714615). References Quinkler, M., et al.: J. Clin. Endocrinol. Metab., 88, 2384 (2003), Draper, N., et al.: J. Endocrinol., 186, 251 (2005), Kotlowska, A., et al.: Clin. Biochem., 42, 448 (2009),

Applications 7α-Hydroxycholesterol-d7 is used as a standard in a biochemical method studying the measurement of F2-isoprostane hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, hydroxycholesterols in plasma and liver of hepatitis patients. References Yoshida, Yazukazu., Analytical Biochemistry, 379, 105-115, (2008)

Applications Isotope labelled Estrone (E889050), which is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Both, D. et al.: Anal. Prof. Drug Subst. 1983 12 pp135-1892. Goodman-Gruen, D. et al.: J. Clin. Endocrinol. Metab. 1996 Aug;81(8):2999-3003.

Ropinirole (SKF 101468) is a D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis properties.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Isotope labelled 3’-Hydroxy Stanozolol is one of the main metabolites of Stanozolol (S684500), an internal standard in doping analysis. References Chung, B., et al.: J. Anal. Toxicol., 14, 91 (1990), Schanzer, W., et al.: J. Steroid Biochem., 36, 153 (1990), Phillis, B., et al.: Eur. J. Pharmacol., 398, 263 (2000),

Lanosterol - 90% is a sterol compound, which is a biochemical precursor to steroids. It is derived from various animal and plant sources, typically synthesized through the enzymatic conversion of squalene. Lanosterol functions through a significant role in the biosynthetic pathway of cholesterol and other essential sterols. This involves the cyclization process, where lanosterol is metabolized into cholesterol through a series of reactions catalyzed by specific enzymes. Lanosterol - 90% is predominantly used in research focused on cholesterol synthesis and metabolism, offering key insights into sterol-related pathways. It is also used in studies aimed at understanding its potential therapeutic effects, including its role in cataract treatment through the dissolution of protein aggregates in the lens. Additionally, lanosterol is utilized in exploring anti-inflammatory and antiviral properties, making it a versatile compound in the development of pharmaceutical applications. Its role in understanding cholesterol-related disorders, such as cardiovascular diseases, underscores its significance in biochemical and clinical research.

Promegestone is a synthetic progestogen, which is derived from progesterone. It functions by mimicking the effects of natural progesterone in the body, acting primarily on progesterone receptors to modulate reproductive processes. This progestogenic agent alters the lining of the uterus and inhibits gonadotropin production, thereby exerting its effects on ovulation and menstrual cycles. Promegestone is primarily utilized in the field of reproductive medicine and gynecology. It is employed in hormonal replacement therapy, contraception, and the management of menstrual disorders. Its role in controlling endometrial proliferation makes it valuable for conditions like endometriosis and in assisted reproductive technologies. The molecular structure of Promegestone grants it specific affinities and activities, allowing for targeted therapeutic interventions. Scientists continually study its pharmacokinetics and dynamics to better understand its role and optimize its applications in clinical settings.

Tenacissoside F is a newly identified steroidal glycoside。Its homologous compound Tenacissoside G can inhibit P-gp and block HepG2 cells in G1/S phase.

Cyclic alcohol

Applications Calusterone-d5 is the labeled analogue of Calusterone (C148900), a synthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid). References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976); Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977)

Applications Labelled Δ4-Pregnen-20α-ol-3-one (P712215). Δ4-Pregnen-20α-ol-3-one is the main metabolite of Progesterone (P755900). Studies shows regulation of estrogen receptor levels in breast cancer by Δ4-Pregnen-20α-ol-3-one and other progesterone metabolites. References Zhang, L. et al.: Yaoz. Xueb., 39, 613 (2004); Pawlak, K.J. et al.: J. Steroid. Biochem. Mol. Biol., 107, 172 (2007);

Allolithocholic acid (allo-LCA) is found in the urine of infants with biliary atresia and promotes intestinal and hepatic metabolism.

Applications A metabolite of 9-cis-Retinoic acid (R245000). References Omiecinski, C., et al.: Cancer Res., 50, 4315 (1990), Chapman, D., et al.: Biochem. Pharmacol., 48, 1807 (1994), White, J., et al.: J. Biol. Chem., 271, 29922 (1996), Chen, H., et al.: Drug Metab. Dispos., 28, 1051 (2000),

Applications Bolandiol is a unique anabolic steroid with androgenic, estrogenic, and progestational activities. References Schrader, Y., et al.: Drug Metab. Dispos., 34, 1328 (2006), Gao, W., et al.: Drug Discov. Today, 12, 241 (2007), Diel, P., et al.: Toxicol. Lett., 177, 198 (2008), Tang, H., et al.: Steroids, 74, 684 (2009),

Applications A metabolite of Mifepristone. References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Applications Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. References Akatsuka, K. et al.: Mei. Yak. Daig. Ken. Kiyo, 5, 11 (1975); Tank, N.A. et al.: Res. J. Pharmac. Biol. Chem. Sci., 2, 817 (2011);

Stability Light Sensitive Applications A metabolite of Letrozole. References Koyama, E., et al.: Ther. Drug Monit., 15, 224 (1993), Pfister, C., et al.: J. Pharm. Sci., 83, 520 (1994), Vander H.Y., et al.: J. Pharm. Biomed. Anal., 24, 723 (2001), Cohen, M., et al.: Clin. Cancer Res., 8, 665 (2002),

Applications Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615). References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),

Ophiopogonin B has antitumor activity and is a prospective inhibitor of PI3K/Akt.

Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.

Natural alkaloid

Tigogenin: steroidal sapogenin used in steroid drug synthesis, may protect against osteoporosis.

Stability Hygroscopic Applications Dexamethasone 11,21-diacetate, is an impuriy of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Ergostenol (Ergost-8(14)-en-3beta-ol) is a biological precursor and a provitamin of vitamin D2.

Applications Anabolic steroid. Controlled substance. References Arriza, J., et al.: Science, 237, 268 (1987), Lill, M., et al.: J. Med. Chem., 47, 6174 (2004), Bledsoe, R., et al.: J. Biol. Chem., 280, 31283 (2005),

Applications Methenolone acetate is an anabolic steroid. This is a controlled substance. References Schiffer, M., et al.: J. Clin. Invest., 108, 807 (2001), Okuyama, S., et al.: Clin. Nephrol., 68, 412 (2007), Sjoqvist, F., et al.: Lancet, 371, 1872 (2008),

Timosaponin B III (Anemarsaponin BIII) is a bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge.

Stability Hygroscopic Applications A labelled glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972), Bernstein, I.L., et al.: Chest, 81, 20 (1982),

Cyasterone, a natural EGFR inhibitor, can inhibit growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it maybe a promising anti-cancer agent; it also has antifeeding activity.

Natural alkaloid

Applications 4-Desacetamido-4-fluoro Andarine is a Selective Androgen Receptor Modulator (SARM) that has potential use for treatment of androgen related diseases such as muscle wasting and osteoporosis. 4-Desacetamido-4-fluoro Andarine is also a derivative of Andarine (A637470), a non-steroidal SARM that is used by athletes to enhance performance. References Jones, A., et al.: Endocrinology, 150, 385 (2009); Marhefka, C., et al.: J. Med. Chem., 47, 993 (2004); Thomas, A., et al.: Rapid Comm. Mass Spec., 24, 1124 (2010)

Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma, a component of cell membrane, and has a regulatory function.

Applications Plant sterol, used as a precursor in the synthesis of progesterone. References Han, P., et al.: Biotechnol. App. Biochem., 54, 105 (2009), Matsunaga, I., et al.: Anal. Biochem., 393, 222 (2009), Huang, C., et al.: Plant Physiol., 150, 1192 (2009),

Cortisol, steroid hormone is released in response to stress and a low level of blood glucocorticoids. Its primary functions is to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein and carbohydrate metabolism. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Stability Light Sensitive Applications An antineoplastic (hormonal). References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)

14-Hydroxy sprengerinin C is a natural product from Ophiopogon japonicus.