Iridioids

Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.

Loganic acid( 0.7% solution) has a strong intraocular pressure (IOP)-hypotensive effect, it exhibits both sides effect on superoxide generation. Loganic acid also has protective effects on atherosclerosis risk factors in hypercholesterolemic rabbits, it shows significant anti-inflammatory effects decreasing TNF-α and IL-6 activity in serum.

Natural glycoside

Loganetin is a phytochemical compound derived from the plant Menyanthes trifoliata, commonly known as bogbean. This natural product is sourced from the leaves of the bogbean, a perennial herb found in marshy and boggy environments. The compound is characterized by its potential anti-inflammatory activities and is a subject of interest for research into various therapeutic applications. Loganetin exerts its effects through the modulation of inflammatory pathways, potentially by interacting with cellular signaling mechanisms that regulate the production of inflammatory mediators. This mode of action suggests its significant potential in attenuating inflammation-related responses in biological systems. The uses and applications of Loganetin are still under investigation, primarily in the context of inflammation reduction. Scientists are exploring its efficacy and safety in preclinical models to evaluate its potential benefits and limitations. This ongoing research seeks to elucidate the compound’s detailed mechanisms and possible therapeutic profiles, contributing to our understanding of bioactive phytochemicals in medicine.

Aucubin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Cornuside has immunomodulatory, and anti-inflammatory activities, it has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties. Cornuside can treat myocardial I/R and protect the liver from CCl₄-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses.

Catalpol is an iridoid glycoside, which is a natural compound isolated primarily from the roots of the plant *Rehmannia glutinosa*. This compound is known for its various bioactive properties, functioning predominantly through its ability to modulate antioxidant pathways, regulate inflammatory responses, and exert neuroprotective effects. These modes of action are attributed to its capacity to influence cellular signaling pathways, such as the PI3K/Akt pathway, and to interact with reactive oxygen species (ROS), thereby mitigating oxidative stress. The use of Catalpol extends across multiple research domains, most notably in studies exploring neurodegenerative diseases, diabetes, and ischemic injuries. Its potential to attenuate neuronal damage and improve cognitive function makes it a compound of interest in the development of therapeutic agents for conditions like Alzheimer's disease. Additionally, its anti-inflammatory and hypoglycemic activities suggest applications in the management of chronic inflammatory diseases and metabolic disorders. While extensive research continues to unravel its precise mechanisms and efficacy, Catalpol remains a compound of significant interest in pharmacological and biochemical studies.

Standard reference

Geniposidic acid, one of the main active ingredients in Gardenia jasminoides J. Ellis (Rubiaceae), has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model.

8-O-acetyl shanzhiside methylester (ND01), an iridoid glucoside compound, was isolated from the leaves of Lamiophlomis rotata (Benth.) Kudo, ND01 has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca 2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.

Natural glycoside