Iridioids

Ajugol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Aucubin is an iridoid glycoside, which is a naturally occurring compound found primarily in certain medicinal plants such as Plantago species. This compound is extracted from these botanical sources and has been studied for its diverse biological activities. The mode of action of Aucubin involves modulation of various biochemical pathways, including anti-inflammatory and antioxidant mechanisms. Aucubin has been shown to inhibit the production of pro-inflammatory cytokines and reactive oxygen species, contributing to its protective effects at the cellular level. In scientific research, Aucubin is investigated for its potential applications in treating inflammatory conditions, hepatic disorders, and other diseases where oxidative stress is a contributing factor. Its role in liver protection, neuroprotection, and wound healing has garnered attention, making it a subject of interest for researchers exploring new therapeutic avenues. The ongoing exploration of Aucubin's pharmacological potential underscores its significance in the field of medicinal chemistry and natural product research.

Picroside I is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug candidates for cancer therapy by suppressing Collagenases and Gelatinases. Picroside I can enhance basic fibroblast growth factor(bFGF)-, staurosporine- or dbc-mitogen-activated protein (MAP)-induced neurite outgrowth from PC12D cells.

Harpagoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Morroniside is a naturally occurring secoiridoid glucoside, which is primarily derived from plants such as Cornus officinalis, commonly known as the Japanese cornel dogwood. This compound is isolated through meticulous extraction processes from the fruit of the plant, which has a long history in traditional medicine systems, especially in East Asia. The active mode of action of Morroniside is notably characterized by its potent antioxidant capabilities. It scavenges free radicals and mitigates oxidative stress, offering protective effects at the cellular level. Morroniside is predominantly utilized in scientific studies due to its promising therapeutic potential. It has shown efficacy in modulating neuroprotective pathways, thereby gaining interest in the context of neurological disorders, such as Alzheimer's disease and stroke. Additionally, its anti-inflammatory properties make it a compound of interest in studies targeting chronic inflammatory conditions. Overall, its multifaceted biochemical activities underline its potential role in advancing therapeutic strategies and warrant further investigation in clinical settings.

Natural glycoside

Natural glycoside

Amarogentin is an iridoid glycoside, which is a secondary metabolite found primarily in the roots of the Gentiana lutea plant and other Gentianaceae species. It is renowned for its extreme bitterness and is considered one of the most bitter natural compounds known. Its mode of action involves stimulation of taste receptors, promoting the release of digestive enzymes, and enhancing gastrointestinal motility. This compound is of great interest in pharmacological research due to its potential therapeutic applications. Amarogentin exhibits promising anti-microbial, anti-inflammatory, and hepatoprotective effects, making it a subject of investigation in various biomedical fields. Studies indicate that it may also have anticancer properties by inducing apoptosis in cancer cells and inhibiting tumor growth. Additionally, it's utilized in traditional medicine systems as a digestive stimulant and for treating fevers and gastrointestinal disorders. Due to its diverse biological activities, Amarogentin continues to be a focal point in research aiming to develop novel drug therapies, leverage its bitterness for appetite regulation, and explore its role in enhancing the efficacy of conventional treatments.

Natural glycoside

8-Epideoxyloganic acid offers pain relief, stabilizes bodily functions, reduces inflammation, and may inhibit ROS via NOX activity.

Applications Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins. References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);