Lignans

(-)-Arctigenin is a lignan compound, which is naturally derived from certain plant species, primarily found in the seeds of Arctium lappa, commonly known as burdock. The compound exhibits a diverse mode of action, primarily noted for its ability to inhibit the proliferation of cancer cells through apoptosis induction, cell cycle arrest, and modulation of various signaling pathways. Additionally, it exerts antiviral effects by targeting viral replication processes and exhibits anti-inflammatory properties by downregulating pro-inflammatory cytokines. The uses and applications of (-)-Arctigenin are varied and significant in biomedical research. It is extensively studied for its potential as an anticancer agent across various types of malignancies, including breast and lung cancers. Due to its antiviral properties, it has been evaluated in the context of infections caused by viruses such as HIV and influenza. Additionally, its anti-inflammatory effects have led to investigations into its potential use in treating inflammatory-related diseases. As a compound of interest in natural product chemistry and pharmacology, (-)-Arctigenin serves as a promising candidate for developing novel therapeutic agents.

Oxygen-heterocyclic compound

Oxygen-heterocyclic compound

Technical grade is a natural from Magnolia sieboldii

Taiwanin C, a lignan from Cryptocarya chinensis, boasts anti-inflammatory, antioxidant, and anticancer properties.

Enterodiol is a phytoestrogenic compound, specifically classified as a plant-derived lignan metabolite, which originates from the consumption and subsequent gut microbial transformation of lignans found in dietary fiber-rich foods such as flaxseeds, whole grains, and certain vegetables. The mode of action involves its conversion by intestinal microbiota into enterodiol from precursors such as secoisolariciresinol diglucoside. Once absorbed, enterodiol can interact with estrogen receptors, exhibiting weak estrogenic activity, which contributes to its role as a selective estrogen receptor modulator. Enterodiol's potential uses and applications are diverse, spanning areas of interest such as hormonal modulation, cancer prevention, and cardiovascular health. Due to its ability to emulate estrogen albeit with much weaker potency, it plays a role in mitigating symptoms associated with low estrogen levels, such as those experienced during menopause. Additionally, its antioxidant properties contribute to the reduction of oxidative stress, supporting its examination in studies focused on chronic disease prevention. Current research emphasizes the need to explore its efficacy, bioavailability, and long-term effects to fully understand its implications and potential therapeutic uses within clinical settings.

(-)-Syringaresinol diglucoside is a naturally occurring lignan glycoside, which is predominantly found in certain plant species, such as the roots of Eleutherococcus senticosus (Siberian ginseng) and other similar sources. This compound is categorized as a phytoestrogen due to its ability to elicit weak estrogenic activity by binding to estrogen receptors, which may influence various biological processes. (-)-Syringaresinol diglucoside’s mode of action includes its antioxidant and anti-inflammatory properties. It may modulate the oxidative stress pathways and inflammatory responses, offering potential protective effects against certain diseases. By interfering with specific signaling pathways, it might also demonstrate anti-cancer and anti-viral activities, although more research is needed to fully elucidate these mechanisms. The applications of (-)-Syringaresinol diglucoside extend to various fields of scientific research, including studies focused on its potential therapeutic effects and elucidating its role in plant biochemistry and ecology. Its presence in traditional medicinal plants also underscores its significance in ethnobotanical and pharmacological studies. Current research might investigate its impact on human health, particularly in the context of metabolic disorders and hormone-related conditions.

Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.

(+)-Sesamin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Gomisin J is a natural product and have vasodilatory activity.

(+)-Lyoniresinol 9'-O-glucoside is a compound obtained from the root bark of Lycium barbarum with antimicrobial antioxidant activity activity.

Lactone

Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, it induces apoptosis in MCF-7 breast cancer cells.

Salvadoraside is a glycosylated natural compound, which is derived from the plant Salvadora persica, commonly known as the toothbrush tree. This compound is primarily extracted from the stems and roots of the plant. Its mode of action involves a variety of biochemical pathways, including potential antioxidative, antimicrobial, and anti-inflammatory activities. Salvadoraside interacts with cellular pathways by modulating the expression of specific enzymes and receptors, offering promising avenues in medicinal chemistry. The uses and applications of Salvadoraside are currently being explored in various scientific studies, focusing on its efficacy in dental health due to its natural antimicrobial properties. Furthermore, it is being investigated for broader therapeutic potential, including roles in managing oxidative stress and contributing to inflammatory response regulation. As research progresses, Salvadoraside's contribution to pharmacology could span multiple disciplines, offering insights into novel drug development and natural product chemistry.

Lactone

Matairesinoside is a naturally occurring phenolic compound, which is primarily extracted from certain plant species known for their medicinal properties, such as the Daphne genus. It functions through modulation of various biochemical pathways, exhibiting antioxidant, anti-inflammatory, and potential anti-cancer activities. These actions are mediated via its ability to scavenge free radicals, inhibit pro-inflammatory cytokines, and modulate cellular apoptosis pathways. In a scientific context, Matairesinoside is being explored for its potential therapeutic applications. Its antioxidant activity makes it a candidate for protecting cells against oxidative stress-related damage, which is implicated in aging and various chronic diseases. The compound's anti-inflammatory properties offer potential in the treatment of inflammatory disorders. Furthermore, preliminary studies suggest that Matairesinoside may exert anti-cancer effects by inhibiting tumor growth and inducing apoptosis in certain cancer cell lines. Current research is focusing on its detailed mechanisms of action, bioavailability, and efficacy in various model systems. Overall, Matairesinoside represents a promising molecule for further investigation in the field of pharmacology and therapeutic development.

Phillyrin is a lignan compound, which is a bioactive chemical derived from the seeds and fruits of the plant Forsythia suspensa, a traditional medicinal herb. This compound is recognized for its multifaceted mode of action, primarily through its anti-inflammatory, antioxidant, and antimicrobial properties. Phillyrin functions by modulating signaling pathways, inhibiting oxidative stress, and suppressing pro-inflammatory cytokine production, making it significant in the field of pharmacology. Phillyrin's applications are diverse, extending into therapeutics for conditions characterized by inflammation and oxidative stress. Researchers have demonstrated its potential in mitigating diseases such as arthritis, cardiovascular disorders, and microbial infections. Furthermore, its ability to scavenge free radicals makes it valuable in studies aimed at understanding aging and age-related diseases. The compound's pharmacological benefits are continually being explored in preclinical and clinical settings, highlighting its promise as a candidate for drug development in the management of chronic inflammatory and oxidative-dependent ailments.

Oxygen-heterocyclic compound

Natural glycoside

Macelignan analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Prestegane B is a bioactive compound, which is a natural product extracted from the plant Hewittia sublobata. This compound is sourced from the leaves and stems of the plant, which have been traditionally used in various folk medicines. The extraction process involves detailed phytochemical analysis to isolate the active constituents. Prestegane B operates by modulating specific biochemical pathways, particularly by interacting with cellular receptors and enzymes, ultimately influencing cellular processes and signaling cascades. This mode of action suggests potential applications in modulating inflammatory responses or acting as an antioxidant. The uses and applications of Prestegane B are primarily in the field of medicinal research, where it holds promise as a lead compound for drug development in treating various ailments. Its pharmacological profile is being explored for its efficacy in neurological, anti-inflammatory, and antioxidative contexts. Ongoing studies aim to elucidate its full therapeutic potential and underlying mechanisms, contributing valuable insights to the field of natural product research and pharmacognosy.

Carboxylic acid with additional oxygen functions

Natural glycoside

Please enquire for more information about Chicanin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Oxygen-heterocyclic compound

Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.

Natural glycoside

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal

Oxygen-heterocyclic compound

Fargesin is a naturally occurring compound that is a bioactive constituent of Magnolia flowers. It is derived from the dried buds of Magnolia fargesii, a plant traditionally used in herbal medicine. The compound exhibits a mode of action that involves anti-inflammatory and anti-allergic properties. It operates through the inhibition of the release of pro-inflammatory mediators, thereby reducing inflammation and allergic responses. Fargesin finds its applications primarily in the management of sinusitis and other respiratory tract ailments. Its anti-inflammatory effects make it a valuable molecule in reducing nasal congestion, sinus pressure, and other symptoms associated with rhinitis and sinus infections. Given its natural origin and targeted action, Fargesin is of interest in the development of treatments that aim to alleviate allergic and inflammation-related conditions without the side effects commonly associated with synthetic drugs. Researchers are exploring its potential uses in broader therapeutic contexts, contributing to a growing body of literature on botanical extracts in medical science.

Dehydropodophyllotoxin is a lignan compound, which is derived from the roots and rhizomes of the plant genus Podophyllum. It exhibits its activity primarily as an inhibitor of microtubule assembly. Microtubules are essential components of the cell cytoskeleton, playing a critical role in cell division and intracellular transport. By interfering with microtubule dynamics, dehydropodophyllotoxin disrupts mitosis, leading to cell cycle arrest and potential apoptosis in rapidly dividing cancer cells. This compound has garnered interest in the field of oncology due to its potential antitumor properties. Researchers are exploring its application in the development of chemotherapeutic agents aimed at various types of cancer. Although its precise molecular mechanisms are still under investigation, the ability of dehydropodophyllotoxin to inhibit microtubule formation represents a promising avenue for cancer treatment strategies. Scientists continue to study its pharmacokinetics and therapeutic efficacy in order to better understand its role and optimize its application in clinical settings.

Carboxylic acid with additional oxygen functions

4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies. The compound finds extensive application in the development of chemotherapeutic agents, particularly in targeting various carcinomas. It is of significant interest in oncology research due to its structural similarity to other clinically effective antineoplastic agents. Furthermore, ongoing studies aim to enhance its therapeutic index and specificity through various modifications, making 4'-Demethylpodophyllotoxin a promising candidate in the quest for novel cancer treatments.

Ether phenol

Applications A metabolite of Tamoxifen (T006000), a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines. References Brandt, S., et al.: Anticancer Res., 23, 223 (2003), Coller, J., et al.: Br. J. Clin. Pharmacol., 57, 105 (2004), Parte, P., et al.: Drug Metab. Dispos., 33, 1446 (2005),

Magnolol is a bioactive compound, which is a type of lignan extracted from the bark of the magnolia tree, primarily Magnolia officinalis. It exhibits a diverse range of pharmacological activities, primarily attributed to its anti-inflammatory and antioxidant properties. Through the modulation of various signaling pathways, including the NF-κB pathway, magnolol effectively inhibits the activation of inflammatory mediators and scavenges free radicals. This compound has been extensively studied for its potential applications in addressing oxidative and inflammatory-related diseases. Its inhibitory effects on inflammation make it a promising candidate for research into treatments for conditions such as arthritis, neurodegenerative diseases, and certain types of cancer. Additionally, magnolol's ability to modulate the immune response and its neuroprotective effects have attracted attention in the context of central nervous system disorders. Scientists continue to explore its pharmacokinetics and bioavailability to optimize its therapeutic potential.

Secoisolariciresinol diglucoside is a plant lignan, which is primarily sourced from flaxseed. As a type of phytoestrogen, SDG is known for its antioxidant properties and ability to influence estrogen metabolism. The mode of action involves the conversion of SDG into mammalian lignans such as enterolactone and enterodiol by intestinal microflora, which then exhibit biological activity. These metabolites can bind to estrogen receptors, thereby exerting weak estrogenic or antiestrogenic effects depending on endogenous estrogen levels. The uses and applications of Secoisolariciresinol diglucoside are varied, primarily focusing on its potential health benefits. Its antioxidant activity is being studied for possible roles in the prevention of oxidative stress-related diseases. The phytoestrogenic activity of SDG has garnered interest for its effects on hormone-dependent conditions, such as menopausal symptoms and potentially in hormone-related cancer prevention. Current research also explores its impact on cardiovascular health, metabolic syndrome, and immune function. Despite these promising areas, it is essential to approach findings with scientific rigor, and further studies are necessary to substantiate these potential health benefits fully.

(+/-)-Secoisolariciresinol is a lignan compound, a type of polyphenolic phytonutrient, primarily found in plant-based sources. It is abundantly obtained from flaxseeds, but also present in other seeds and whole grains. The compound undergoes metabolism by gut microflora to produce enterolignans, such as enterodiol and enterolactone, which exhibit weak estrogenic and antioxidant properties. (+/-)-Secoisolariciresinol's mode of action involves binding to estrogen receptors, potentially modulating estrogenic activity, thus exhibiting both estrogenic and anti-estrogenic effects depending on physiological conditions. Its structural similarity to endogenous estrogens allows it to potentially influence hormone-related pathways and oxidative stress mechanisms. The primary applications of (+/-)-Secoisolariciresinol focus on its role in health sciences, particularly concerning its effects on cardiovascular health, hormone-related conditions, and cancer prevention. Research indicates potential benefits in reducing the risk of hormone-dependent cancers such as breast and prostate cancer, given its ability to act as a natural regulator of estrogen levels. Additionally, as an antioxidant, it may aid in reducing oxidative stress, thereby contributing to vascular health and the mitigation of chronic disease progression.

Schisantherin E is a natural lignan from Schisandra chinensis., which might be hepatoprotective, sedative, anticancer, and anti-inflammatory activities.

(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase.

Tigloylgomisin H boosts QR, upregulates phase II enzymes via Nrf2-ARE, may prevent liver cancer.

Ether alcohol phenol

(+)-Syringaresinol, 98% is a lignan compound, which is a type of phenolic compound found in a variety of plant sources. It is primarily derived from the wood and bark of specific plant species, most notably those within the Syringa genus. The mode of action of (+)-Syringaresinol involves its function as an antioxidant, where it can scavenge free radicals and inhibit oxidative stress within biological systems. In research settings, (+)-Syringaresinol is utilized for its potential health benefits, which include anti-inflammatory and chemopreventive properties. It is often studied for its role in modulating various biological pathways and its influence on metabolic and cellular processes. Additionally, this compound is investigated for potential therapeutic applications in the management of chronic diseases such as cardiovascular conditions and certain cancers. Scientists are particularly interested in its biochemical interactions and the potential synergistic effects it might have with other bioactive compounds.

Picropodophyllone is one of the lignans from the roots of D. aurantiocaulis and D. pleianthum.

Matairesinol 4'-O-b-gentiobioside is a lignan glycoside, which is a class of phytoestrogens found in various plant species. It is derived from natural sources such as seeds, cereals, and vegetables. The compound is metabolized in the human body by intestinal microflora, transforming into enterolignans, which exhibit estrogen-like activity. This mode of action includes the modulation of estrogen receptors, thereby influencing various physiological processes. Matairesinol 4'-O-b-gentiobioside is primarily studied for its potential health benefits due to its antioxidant properties. Research suggests its applications in reducing oxidative stress and the risk of hormone-related cancers. Additionally, it may support cardiovascular health by interacting with lipid metabolism. Ongoing studies explore its role in modulating gut microbiota and its implications in chronic disease prevention. The compound's biochemical properties and potential therapeutic roles continue to be a significant area of interest within the scientific community.

Pinoresinol dimethyl ether is a lignan compound, which is a type of polyphenolic substance. It is naturally sourced from various plant materials, prominently found in seeds, bark, and roots of certain plant species. The compound exhibits significant antioxidant activity, which is attributed to its ability to scavenge free radicals and protect cells from oxidative stress. Having strong radical scavenging abilities, Pinoresinol dimethyl ether is extensively studied for its potential role in preventing oxidative damage in biological systems. Its applications are primarily centered in biochemistry and pharmacology, where it is utilized to explore mechanisms of antioxidant activity and to evaluate its potential therapeutic benefits. Additionally, research studies investigate its role in mitigating inflammatory processes and its potential as a chemopreventive agent. As a result, Pinoresinol dimethyl ether is of considerable interest for its implications in health-related research and natural product chemistry.

(-)-Arctigenin is a natural lignan, which is an active compound isolated from plants such as Arctium lappa (greater burdock) and other members of the Asteraceae family. It acts via several biochemical pathways, notably by inhibiting cellular proliferation and inducing apoptosis in certain cancer cell lines. Additionally, (-)-Arctigenin can modulate immune responses and possesses anti-inflammatory and antiviral properties by interfering with viral replication processes. The compound is being extensively researched for its therapeutic potential, particularly in oncology, where its ability to sensitize tumor cells to chemotherapy is promising. Moreover, its anti-inflammatory effects are of interest in the treatment of chronic inflammatory diseases. Researchers are also investigating its potential application in combatting viral infections, including its efficacy against HIV and influenza. Detailed studies are ongoing to fully elucidate its mechanisms and optimize its use in therapeutic interventions.

Oxygen-heterocyclic compound

Ether alcohol phenol

Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the

Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.

(+/-)-Syringaresinol is a type of lignan, which is a category of polyphenolic compounds. It is primarily sourced from various plant materials, including seeds, roots, and barks of certain tree species. These naturally occurring compounds are integral to the plant's defense mechanisms and provide various ecological benefits. The mode of action of (+/-)-Syringaresinol involves its interaction with cellular pathways to exert antioxidant effects. It achieves this by scavenging free radicals and modulating oxidative stress-related pathways. Additionally, it has affinity for interaction with certain cellular receptors, potentially affecting signal transduction and expression of genes related to apoptosis and proliferation. In terms of applications, (+/-)-Syringaresinol is studied for its potential therapeutic effects in the pharmaceutical and nutraceutical industries. Its antioxidant properties make it a candidate for mitigating oxidative stress-related diseases, such as cardiovascular disorders and certain cancers. Furthermore, research is ongoing into its potential role in anti-inflammatory and neuroprotective therapies. The ability of (+/-)-Syringaresinol to influence cellular processes makes it an interesting subject for further pharmacological studies, with implications for developing novel therapeutic agents.

Lactone