Lignans

Natural glycoside

Yangambin: selective PAF antagonist, hypotensive, inhibits Ca2+ influx, induces peripheral vasodilation, affects CNS.

(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis and shows antioxidant and anti-inflammatory activities and can be used in studies

(+/-)-Matairesinol is a lignan compound, which is a type of phytoestrogen. It is primarily sourced from various plant species, such as flaxseeds, sesame seeds, and whole grains. This compound is an important constituent of the plant's defense mechanisms and contributes to their overall health properties. The mode of action of (+/-)-Matairesinol involves its conversion into enterolactone by intestinal microflora. Enterolactone exhibits estrogenic activity, which allows it to bind to estrogen receptors in the human body. This binding leads to its potential antioxidant properties and modulation of biological processes linked to hormone-dependent diseases. The uses and applications of (+/-)-Matairesinol are predominantly in the fields of nutrition and health research. It is studied for its potential effects on reducing the risk of hormone-related cancers, cardiovascular diseases, and osteoporosis. Additionally, its antioxidant properties contribute to its investigation in the context of overall health maintenance and chronic disease prevention. Researchers focus on its role in human health as part of dietary interventions and its potential therapeutic applications.

Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity.

(-)-Matairesinol is a polyphenolic lignan compound, which is primarily sourced from various plants, including flaxseeds, sesame seeds, and whole grains. This compound belongs to a group of plant-derived molecules known as phytoestrogens, which exhibit structural similarity to estrogen hormones. The mode of action of (-)-matairesinol involves its metabolic conversion in the human gastrointestinal tract into enterolignans, specifically enterolactone and enterodiol. These metabolites can mimic or modulate the hormone estrogen's action by binding to estrogen receptors, thereby influencing various estrogen-dependent biological processes. The uses and applications of (-)-matairesinol are mainly centered around its potential health benefits. It has been studied for its role in reducing the risk of hormone-related cancers, such as breast and prostate cancer, due to its potential antiestrogenic effects. Additionally, (-)-matairesinol may have antioxidative and cardioprotective properties, making it a subject of interest for cardiovascular health research. Scientists are actively investigating its broader implications in human health, aiming to elucidate its role in chronic disease prevention and overall well-being.