Lignans

Oxygen-heterocyclic compound

Asatone is a synthetic compound, categorized within a class of specialized chemical analogs, which is derived from intricate organic synthesis techniques. Its origin lies in a complex multi-step chemical process that involves the manipulation of reactive intermediates under controlled conditions to yield the desired molecular structure. The compound operates primarily by interacting with specific biochemical pathways, modulating enzymatic activity through competitive inhibition. This mode of action allows it to selectively bind to active sites, influencing the metabolic rate of substrates and altering systemic biochemical responses in target organisms. Asatone's applications are diverse and predominantly centered around biochemical research. Scientists utilize this compound to explore metabolic pathways and study its effects on enzyme regulation within various experimental models. Its potential in facilitating novel insights into metabolic disorders and contributing to the development of therapeutic strategies makes it a valuable tool in the realm of scientific investigation. Researchers employ Asatone in vitro and in vivo studies to elucidate its mechanistic properties and to understand its broader implications within biological systems.

Natural glycoside

Natural glycoside

Lactone

DHCA: lignan from calabash; blocks osteoclasts, prevents bone loss; estrogen receptor agonist.

Oxygen-heterocyclic compound

Compound with non-condensed furan ring

(-)-Nortrachelogenin is a bioactive lignan compound, which is a type of secondary metabolite derived from various plant sources, including Forsythia species. This compound is predominantly isolated from the stems and leaves of these plants and is recognized for its potential pharmacological properties. Its mode of action involves interactions with cellular processes, primarily through modulation of signaling pathways and oxidative stress response. (-)-Nortrachelogenin has demonstrated inhibitory effects on specific enzymes and receptors, suggesting its role in anti-inflammatory and anticancer mechanisms. In terms of uses and applications, (-)-Nortrachelogenin is investigated for its potential in both therapeutic and preventive settings. It is being explored for its antitumor, antiviral, and antioxidant activities, making it a candidate for drug development in the management of cancer, viral infections, and oxidative stress-related conditions. Its ability to interfere with cellular pathways offers a wide scope for research in pharmacodynamics and drug formulation, making it a compound of significant interest in the realm of natural product chemistry and pharmacology.

(+/-)-Pinoresinol is a plant-derived lignan, which is primarily sourced from various plant species, including olives, sesame seeds, and other lignan-rich plants. As an emerging compound in the field of natural products, it is extracted through processes targeting its abundant presence in lignin-containing materials. The mode of action of (+/-)-Pinoresinol involves its participation in the antioxidant defense system, where it can effectively scavenge free radicals and modulate oxidative stress. This activity is mediated by its ability to influence cellular pathways associated with oxidative systems and signal transduction mechanisms. The uses and applications of (+/-)-Pinoresinol are predominantly found within the realms of biochemical research and pharmacological studies. Its antioxidant properties make it a compound of interest for investigating oxidative stress-related conditions and exploring potential therapeutic implications. Furthermore, research into (+/-)-Pinoresinol's role in metabolic modulation and its potential effects on enzymes related to lignan transformation have garnered significant attention. This compound serves as an essential tool for scientists aiming to elucidate the complex biochemical interactions and benefits of lignans, contributing to the development of novel insights in health-related fields.

Nordihydroguaiaretic acid analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage.

Oxygen-heterocyclic compound

Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.

Lactone

Kadsurin A is a naturally occurring lignan, which is a type of secondary metabolite. Derived from various plant sources, particularly those belonging to the Piperaceae family, this compound has been identified in plants used traditionally for medicinal purposes. Kadsurin A exhibits a range of bioactivities due to its ability to interact with multiple biological targets. The mode of action of Kadsurin A involves modulating various cellular pathways, including antioxidant and anti-inflammatory pathways. By influencing these pathways, it demonstrates potential therapeutic effects in the mitigation of oxidative stress and inflammation, which are critical factors in the development of numerous diseases. In terms of applications, Kadsurin A is primarily studied for its potential use in pharmacological research and drug development. Its unique bioactive profile makes it a candidate for investigating potential treatments for conditions such as cancer, neurodegenerative diseases, and cardiovascular disorders. Researchers continue to explore its mechanism of action and therapeutic efficacy through in vitro and in vivo studies, aiming to uncover its full potential in clinical settings.

Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus.

Oxygen-heterocyclic compound

Lactone

Ether phenol

Natural glycoside

Fargesin may act as a β1AR antagonist to shield rat hearts from ischemia/reperfusion damage and can also enhance dyslipidemia and hyperglycemia.

(+)-Lariciresinol is a lignan, a type of polyphenolic compound, which is primarily derived from plant sources such as flaxseeds, sesame seeds, and whole grains. As a naturally occurring compound in these plants, it plays a role in their defense mechanisms against pathogens. The mode of action of (+)-Lariciresinol involves its ability to act as an antioxidant. It scavenges free radicals and reactive oxygen species, thereby reducing oxidative stress, which can damage cellular components like DNA, proteins, and lipids. This antioxidative property contributes to its potential protective effects on human health. In scientific research, (+)-Lariciresinol is studied for its various applications, particularly its role in reducing the risk of chronic diseases. It is metabolized by the human gut microbiota into enterolactone, a compound that may have estrogenic and anti-estrogenic effects, potentially influencing hormone-related diseases. Moreover, its antioxidant properties are being explored for their potential in mitigating conditions associated with oxidative stress, such as cardiovascular diseases and certain types of cancers. Overall, (+)-Lariciresinol is of significant interest in nutraceutical research and the development of functional foods.

Schizantherin B is a natural diterpenoid compound, which is isolated from the traditional Chinese medicinal plant Schizandra chinensis. It exhibits numerous biological activities due to its complex molecular structure. The primary mode of action of Schizantherin B involves modulation of multiple signaling pathways, which contributes to its anti-inflammatory, antioxidant, and neuroprotective effects. Researchers have also identified its role in inhibiting cell proliferation and inducing apoptosis in various cancer cell lines. Given its diverse bioactivities, Schizantherin B is extensively studied for potential therapeutic applications. It has shown promise in preclinical studies for the treatment of neurological disorders, owing to its neuroprotective properties. Additionally, its anti-cancer potential is being explored in experimental oncology. Schizantherin B's action as a natural bioactive compound makes it a valuable subject for further pharmacological research, particularly in exploring its efficacy and safety for future therapeutic use.

d-Epigalbacin ((-)-Zuonin A) is a naturally occurring lignin.

Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.

Schisanhenol protects heart mitochondria, has antioxidative effects on LDL, and prevents apoptosis by inhibiting ROS.

Ether alcohol phenol

Polyphenol

Syringaresinol-di-O-glucoside is a lignan-derived glucoside, which is a naturally occurring compound found predominantly in the Syringa plant, part of the Oleaceae family. This compound is classified as a plant lignan glycoside, which is obtained through extraction from natural botanical sources, specifically those of the Syringa genus. Its mode of action primarily involves antioxidant activity, where it scours and neutralizes free radicals, protecting cellular structures from oxidative stress. This mechanism is vital in mitigating the damage caused by reactive oxygen species within biological systems. The primary applications and uses of Syringaresinol-di-O-glucoside are found within scientific research, particularly in studies focusing on pharmacology and biochemistry, where its effects on health and cellular aging processes are investigated. Additionally, the compound has been studied for its potential therapeutic benefits, including anti-inflammatory and chemopreventive properties, making it of interest in developing treatments for various degenerative diseases. Researchers analyze its interaction at the molecular level to explore its efficacy as a lead compound in the development of new pharmaceutical drugs that target oxidative stress-related pathways.

Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.

Hedyotisol B is a lignan isolated and purified from the fruit of Cyathea spinosa with antioxidant activity.

Polyphenol

(-)-Asarinin is a naturally occurring lignan, which is an organic compound extracted primarily from the bark and roots of plants in the family Lauraceae, notably Asarum species. This compound is widespread in several traditional medicinal plants used in East Asia. (-)-Asarinin functions through a variety of biochemical pathways, often exhibiting antioxidant and anti-inflammatory properties by modulating key signaling pathways and inhibiting free radical formation. In addition, it is known to interact with cellular receptors to influence gene expression and cellular responses, providing a multifaceted mechanism of action. Research has explored the uses and applications of (-)-Asarinin in several pharmacological contexts. It has shown potential in modulating immune responses, offering therapeutic benefits in inflammatory diseases, and may exert protective effects against certain cardiovascular conditions. Furthermore, its antioxidant capabilities are under investigation for neuroprotective roles, potentially benefiting neurodegenerative disease research. As scientific understanding advances, the versatility and efficacy of (-)-Asarinin continue to make it a subject of intense study within the field of natural product chemistry and pharmacology.

(+)-Isolariciresinol is a naturally occurring lignan, which is derived from plant sources such as flaxseeds, sesame seeds, and various other seeds and grains. It is known for its antioxidant properties, which function by neutralizing free radicals, thereby reducing oxidative stress within biological systems. This lignan plays a role in modulating various biochemical pathways due to its potential to influence receptor-mediated activities, particularly estrogenic pathways. Its mode of action involves mimicking or modulating the activity of endogenous estrogens, thereby impacting metabolic and cellular processes. The applications of (+)-Isolariciresinol are diverse, encompassing research fields like oncology, cardiology, and nutrition. It is studied for its potential in reducing the risk of certain hormone-related cancers, promoting cardiovascular health, and enhancing metabolic functions. Its role as an antioxidant also makes it a subject of interest in the study of aging and chronic diseases, offering potential insights into therapeutic strategies for mitigating oxidative damage. As a biologically active compound, its precise mechanisms and interactions within human physiology continue to be areas of active research.

Ether phenol

Compound with non-condensed furan ring

Applications A metabolite of Icariin. Icaritin and Desmethylicaritin, two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. References Carmichael, J; Cancer Res 1987, 47, 943,,,Franke, T; Science 1997, 275, 665,,,Kowalski, J; Pharmacol Rep 2005, 57, 390,,,Lee, G; Eur J Pharmacol 2006, 551, 143,,,

Honokiol - 98% is a high-purity bioactive compound derived from the bark of Magnolia species. This natural lignan is obtained through advanced extraction and purification techniques to achieve a concentration of 98%, ensuring its efficacy for research and potential therapeutic applications. Honokiol exhibits a variety of bioactivities by modulating key cellular pathways. It acts as an antioxidant, anti-inflammatory, and anticancer agent through mechanisms such as inhibiting the NF-kB pathway, inducing apoptosis in cancer cells, and modulating neurotransmitter systems. The compound's diverse activity profile makes it a subject of interest in the study of neurodegenerative diseases, oncology, and chronic inflammatory conditions. Its applications are broad, encompassing research into its potential as a therapeutic agent in contexts such as anxiety, tumor suppression, and neuroprotection. The scientific community investigates Honokiol for its multifaceted roles, ranging from influencing cellular redox balance to altering signal transduction pathways. This positions Honokiol - 98% as a versatile tool in the advancement of biomedical research and therapeutic innovation.

Applications Schisantherin B is a bioactive of lignans isolated from Schisandra chinesis which protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice. References Xu, M., et al.: Physiol. Behav., 167, 265-273 (2016)

Ether phenol

erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether Extract from Brazilian rubber with inhibitory activity against human leukocyte elastase.

Asperphenamate, a metabolite from Aspergillus flatiipes, has IC50s of 92.3-97.9 μM in various cancer cells, showing anticancer properties.