Lignans

Natural glycoside

Yangambin: selective PAF antagonist, hypotensive, inhibits Ca2+ influx, induces peripheral vasodilation, affects CNS.

(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis and shows antioxidant and anti-inflammatory activities and can be used in studies

(+/-)-Matairesinol is a lignan compound, which is a type of phytoestrogen. It is primarily sourced from various plant species, such as flaxseeds, sesame seeds, and whole grains. This compound is an important constituent of the plant's defense mechanisms and contributes to their overall health properties. The mode of action of (+/-)-Matairesinol involves its conversion into enterolactone by intestinal microflora. Enterolactone exhibits estrogenic activity, which allows it to bind to estrogen receptors in the human body. This binding leads to its potential antioxidant properties and modulation of biological processes linked to hormone-dependent diseases. The uses and applications of (+/-)-Matairesinol are predominantly in the fields of nutrition and health research. It is studied for its potential effects on reducing the risk of hormone-related cancers, cardiovascular diseases, and osteoporosis. Additionally, its antioxidant properties contribute to its investigation in the context of overall health maintenance and chronic disease prevention. Researchers focus on its role in human health as part of dietary interventions and its potential therapeutic applications.

Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity.

(-)-Matairesinol is a polyphenolic lignan compound, which is primarily sourced from various plants, including flaxseeds, sesame seeds, and whole grains. This compound belongs to a group of plant-derived molecules known as phytoestrogens, which exhibit structural similarity to estrogen hormones. The mode of action of (-)-matairesinol involves its metabolic conversion in the human gastrointestinal tract into enterolignans, specifically enterolactone and enterodiol. These metabolites can mimic or modulate the hormone estrogen's action by binding to estrogen receptors, thereby influencing various estrogen-dependent biological processes. The uses and applications of (-)-matairesinol are mainly centered around its potential health benefits. It has been studied for its role in reducing the risk of hormone-related cancers, such as breast and prostate cancer, due to its potential antiestrogenic effects. Additionally, (-)-matairesinol may have antioxidative and cardioprotective properties, making it a subject of interest for cardiovascular health research. Scientists are actively investigating its broader implications in human health, aiming to elucidate its role in chronic disease prevention and overall well-being.

Carboxylic acid with additional oxygen functions

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG)

Arctiin is a lignan compound, which is a naturally occurring polyphenolic substance. It is extracted primarily from the seeds of plants in the Asteraceae family, such as Arctium lappa, commonly known as burdock. Arctiin acts as a bioactive compound that interacts with various biological pathways, exhibiting antioxidant, anti-inflammatory, and anti-carcinogenic properties. The molecular action of Arctiin involves modulation of cellular signaling pathways, including the inhibition of matrix metalloproteinases and the activation of estrogen receptors, which are crucial in maintaining skin integrity and reducing oxidative stress. These mechanisms contribute to its potential to enhance dermal health and mitigate age-related skin changes. Arctiin is extensively studied for its applications in dermatological and anti-aging research. It has shown promise in promoting skin elasticity, reducing wrinkles, and serving as a protective agent against environmental stressors. Furthermore, its role in modulating cellular activity makes it a subject of interest in cancer research, particularly in exploring its capability to inhibit tumor growth and proliferation. The compound’s diverse biological activities underscore its significance in scientific investigations focused on therapeutic and cosmetic advancements.

(+)-Sesamolin analytical standard provided with w/w absolute assay, to be used for quantitative titration.