Lignans

Hedyotisol B is a lignan isolated and purified from the fruit of Cyathea spinosa with antioxidant activity.

Polyphenol

(-)-Asarinin is a naturally occurring lignan, which is an organic compound extracted primarily from the bark and roots of plants in the family Lauraceae, notably Asarum species. This compound is widespread in several traditional medicinal plants used in East Asia. (-)-Asarinin functions through a variety of biochemical pathways, often exhibiting antioxidant and anti-inflammatory properties by modulating key signaling pathways and inhibiting free radical formation. In addition, it is known to interact with cellular receptors to influence gene expression and cellular responses, providing a multifaceted mechanism of action. Research has explored the uses and applications of (-)-Asarinin in several pharmacological contexts. It has shown potential in modulating immune responses, offering therapeutic benefits in inflammatory diseases, and may exert protective effects against certain cardiovascular conditions. Furthermore, its antioxidant capabilities are under investigation for neuroprotective roles, potentially benefiting neurodegenerative disease research. As scientific understanding advances, the versatility and efficacy of (-)-Asarinin continue to make it a subject of intense study within the field of natural product chemistry and pharmacology.

(+)-Isolariciresinol is a naturally occurring lignan, which is derived from plant sources such as flaxseeds, sesame seeds, and various other seeds and grains. It is known for its antioxidant properties, which function by neutralizing free radicals, thereby reducing oxidative stress within biological systems. This lignan plays a role in modulating various biochemical pathways due to its potential to influence receptor-mediated activities, particularly estrogenic pathways. Its mode of action involves mimicking or modulating the activity of endogenous estrogens, thereby impacting metabolic and cellular processes. The applications of (+)-Isolariciresinol are diverse, encompassing research fields like oncology, cardiology, and nutrition. It is studied for its potential in reducing the risk of certain hormone-related cancers, promoting cardiovascular health, and enhancing metabolic functions. Its role as an antioxidant also makes it a subject of interest in the study of aging and chronic diseases, offering potential insights into therapeutic strategies for mitigating oxidative damage. As a biologically active compound, its precise mechanisms and interactions within human physiology continue to be areas of active research.

Ether phenol

Compound with non-condensed furan ring

Applications A metabolite of Icariin. Icaritin and Desmethylicaritin, two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. References Carmichael, J; Cancer Res 1987, 47, 943,,,Franke, T; Science 1997, 275, 665,,,Kowalski, J; Pharmacol Rep 2005, 57, 390,,,Lee, G; Eur J Pharmacol 2006, 551, 143,,,

Honokiol - 98% is a high-purity bioactive compound derived from the bark of Magnolia species. This natural lignan is obtained through advanced extraction and purification techniques to achieve a concentration of 98%, ensuring its efficacy for research and potential therapeutic applications. Honokiol exhibits a variety of bioactivities by modulating key cellular pathways. It acts as an antioxidant, anti-inflammatory, and anticancer agent through mechanisms such as inhibiting the NF-kB pathway, inducing apoptosis in cancer cells, and modulating neurotransmitter systems. The compound's diverse activity profile makes it a subject of interest in the study of neurodegenerative diseases, oncology, and chronic inflammatory conditions. Its applications are broad, encompassing research into its potential as a therapeutic agent in contexts such as anxiety, tumor suppression, and neuroprotection. The scientific community investigates Honokiol for its multifaceted roles, ranging from influencing cellular redox balance to altering signal transduction pathways. This positions Honokiol - 98% as a versatile tool in the advancement of biomedical research and therapeutic innovation.

Applications Schisantherin B is a bioactive of lignans isolated from Schisandra chinesis which protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice. References Xu, M., et al.: Physiol. Behav., 167, 265-273 (2016)

Ether phenol

erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether Extract from Brazilian rubber with inhibitory activity against human leukocyte elastase.

Asperphenamate, a metabolite from Aspergillus flatiipes, has IC50s of 92.3-97.9 μM in various cancer cells, showing anticancer properties.