Stilbenoids

Oxyresveratrol is a derivative of resveratrol, extracted from the roots of Morus alba L and Artocarpus lakoocha. In cell lines, oxyresveratrol inhibits nitrite accumulation on the culture medium of lipopolysaccharide (LPS) by reducing the expression of the iNOS protein. Recent studies have reported in vitro activity against 3CLpro enzymes to avoid DNA replication of SARS-CoV-2 (Covid-19).

Trans-Resveratrol 3-O-b-D-glucuronide is a resveratrol metabolite, which is derived from the metabolism of trans-resveratrol, a polyphenolic compound found primarily in grapes, red wine, and certain berries. This metabolite is produced in the liver through glucuronidation, a process enhancing solubility and facilitating excretion. With respect to its mode of action, trans-Resveratrol 3-O-b-D-glucuronide is known to retain some bioactivity of its precursor, trans-resveratrol. It may interact with cellular signaling pathways involved in inflammation and oxidative stress, thereby exhibiting potential anti-inflammatory and antioxidant properties. This compound has shown the ability to modulate the expression of certain genes related to inflammatory responses, although its exact mechanisms and efficacy require further investigation. The primary uses and applications of trans-Resveratrol 3-O-b-D-glucuronide lie in biochemical and pharmacokinetic studies exploring the metabolism of resveratrol in humans and animals. Researchers are particularly interested in its potential therapeutic implications for chronic diseases influenced by inflammation and oxidative stress, though clinical applications remain largely in the investigational stage. Understanding its roles can aid in the development of more effective therapeutic strategies targeting resveratrol pathways.

Bioactive stilbene isolated from pigeon pea (Cajanus cajan) leaves