DNA Cross Linkers

Stability Moisture sensitive Applications A thiol reactive iron chelator. References Arya, R., et al.: Bioconjugate Chem 1991, 2, 323,,,Ebright, Y; Biochemistry 1992, 31, 10664,,,Gaponenko, V; Biochemistry 2000, 39, 15217, Vogtherr, M; J Mol Biol 2002, 318, 1097,,Vogtherr, M; J Mol Biol 2002, 318, 1097

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins. Carmustine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Platinum-based anti-cancer agent; induces apoptosis

Stability Hygroscopic Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links. References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),

Applications 1-Acetyl-2,2,5,5-tetramethyl-3-pyrroline-3-carboxylic Acid N-Hydroxysuccinimide Ester (cas# 1076198-74-7) is a compound useful in organic synthesis.

Temozolomide is an imidazotetrazine alkylating agent. It has anti-tumor activity against a broad spectrum of tumors, such as leukemias, lymphomas and solid tumors. Temozolomide induces G2/M arrest, preventing cells from entering mitosis and, therefore, apoptosis. As a drug resistance-modifying agent it is used for studying drug resistance mechanisms in glioblastoma cell lines. Temozolomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Stability Hygroscopic Applications A sulfhydryl cross-linking reagent. References Loo, T.W., et al.: J. Biol. Chem., 276, 40, 36877 (2001)

SG3199 is an advanced agricultural plant growth regulator, which is synthetically derived with effects mimicking those of natural auxins. Auxins are a class of plant hormones essential for growth regulation, so SG3199 provides critical support for optimizing developmental processes in crops. As a synthetic analog, it functions by modulating cell elongation and division through targeted interaction with cellular auxin receptors, thereby enhancing phenotypic characteristics, such as stem elongation, root initiation, and overall plant vigor. SG3199 finds diverse applications in agricultural settings, primarily aimed at enhancing crop yield and improving resistance to environmental stresses. It is instrumental in seed germination enhancement, facilitating better root system establishment, and optimizing flowering patterns. Moreover, SG3199 contributes significantly to post-harvest management, extending shelf life and preserving crop quality. Its use is particularly advantageous under variable climatic conditions, offering adaptive support to plants through precise hormonal modulation. Researchers continue to explore its potential in integrated crop management systems, aiming to maximize resource efficiency and sustainability in agricultural practices.