Lipids

Applications Labelled 1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability. References Passarotti, C.M., et al.: Bollettino Chimico Farmaceutico, 134, 161 (1995),

Applications Testosterone (T155000) derivative. It is a potent androgen with anabolic properties. Since the begining of the year 2005, the use of steroid precursors (prohormones) is illegal in the United States. Controlled substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Liao, S., et al.: J. Biol. Chem., 248, 6154 (1973), Saartok, T., et al.: Endocrinology, 114, 2100 (1984), Sugawara, T., et al.: J. Biol. Chem., 278, 42487 (2003),

Applications 2-Methylimidazole-d3 is the isotope labelled analog of 2-Methylimidazole (M312985); a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-stream tobacco smoke. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shi, R. et al.: Arch. Biochem. Biophys., 459, 122 (2007); Chan, P.C. et al.: Arch. Toxicol., 82, 399 (2008); Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969)

Stability Light and Temperature Sensitive Applications An isomer of all-trans-Retinal (R240000). References Nakayama, T.A., et al.: J. Biol. Chem., 265, 15762 (1990), Rando, R.R., et al.: Chem. Biol., 3, 255 (1996)

Stability Hygroscopic Applications 3-Oxo-7α,12α-hydroxy-5β-cholanoic Acid is a keto bile acid derivative. References Bortolini, O. et al.: Tetra., 62, 4482 (2006); Bortolini, O. et al.: J. Org. Chem., 67, 5802 (2002); Iguchi, Y. et al.: Biol. Pharm. Bull., 34, 1 (2011);

Applications Labelled lipids. New lipids in food protein hydrolyzates. References Velisek, J., et al.: J. Agric. Chem., 28, 1142 (1980),

Applications Docosanoic Acid Methyl Ester is a long chain fatty acid, existing as a wax and is found in sunflower seeds. It can be used in biodiesel production. References Soh, L. et al.: Green Chem., 13, 1422 (2011); Kanya, T.. et al.: Food Chem., 101, 1552 (2006);

Applications 1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) forms lipid bilayers. In the high temperature phase, the conformation of the chains is liquid-like. In the low temperature phases, the chains are stiff and parallel and they interdigitate. References Ranck, J., et al.: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 488, 432 (1977)

Applications Erucic acid is a long-chain alcohol that acts as an inhibitor of fatty acid oxidation in the heart. Erucic acid originates in rapeseed plants, and is the major fatty acid constituent of rapeseed plant oil extracts and canola oil. References Christophersen, B. & Bremer, J.: BBA-Lipid. Lipid Met., 280, 506 (1972); Ecke, W., et al.: Theor. Appl. Gen., 91, 972 (1995); Metz, J., et al.: Plant Phys., 122, 635 (2000)

Applications Fungisterol is used in the improvement of the measuring methods of composition and total contents of sterols in vegetable oils, study on the antioxidant and antimicrobial activities of supercritical fluid extract of Agaricus brasiliensis. References Zhu, L., et al.: Zhongguo Liangyou Xuebao, 27, 109 (2012); Mazzutti, S., et al.: J. Supercrit. Fluids, 70, 48 (2012)

Applications 1-Palmitoyl-2-oleoyl-3-stearoyl-rac-glycerol is the major triacid triglyceride found in cocoa butter and is used in the improvement of chocolate. References Sampugna, J. et al.: Lipids, 4, 444 (1969); Padley, F.B. et al.: Rev. Int. Choc., 27, 278 (1972);

Applications Cholestane-3β,5α,6α-triol-d7 is labelled Cholestane-3β,5α,6α-triol (C431745) which is present in human atherosclerotic plaques. It also affected toxic cell damage on aortic smooth muscle cells and endothelium in rats. References Breuer, O., et al.: Biochimica et Biophysica Acta, 1302, 145 (1996); Matthias, D., et al.: Atherosclerosis, 63, 115 (1987)

Applications One of two major component of bacterial Lipid A .

Applications Labelled 1-Linoleyl glyceride, a free-living amoeba control agent; also a biomarker of metabolic responses to hepatotoxicants and carcinogens. References Isidorov, V., et al.: Anal. Sci., 21, 1483 (2005); Isidorov, V., et al.: Food Chem., 115, 1056 (2009);

Stability Light Sensitive, Temperature Sensitive Applications A metabolite of Vitamin D, a possibly anti-inflammatory steroid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Boyan, B., et al.: Steroids, 66, 363 (2001), Holick, M., et al.: J. Cell Biochem., 88, 296 (2003), Vogeser, M., et al.: Clin. Chem., 50, 1415 (2004), Singh, R., et al.: J. Clin. Endocrinol. Metab., 91, 3055 (2006),

Applications Cholesteryl stearate

Applications 5α-Pregnane-3β,20(S)-diol, is a metabolite of Progesterone (P755900). References Beall, et al.: Biochem. J., 31, 35 (1937), Okuda, A., et al.: J. Biol. Chem., 259, 7519 (1984), Russell, D., et al.: Biochemistry, 31, 4737 (1992), Kondo, K., et al.: Eur. J. Biochem., 219, 357 (1994), Westerbacka, J., et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003),

Applications A phytosterol content in plant food which showed hypocholesterolemic and hypotriglyceridemic effects in hypercholesterolemic overweight volunteers. Used in the treatment of metabolic disorders. References Kasamo, K., et al.: Plant Physiol., 93, 1049 (1990), Davey, M., et al.: J. Sci. Food Agric., 80, 825 (2000), Nomura, T., et al.: J. Biol. Chem., 280, 17873 (2005), Matos, L., et al.: Food Chem., 102, 406 (2007),