Nucleotides

2'-O-Methyl-5-methylcytidine is a nucleoside that is categorized as a modified nucleic acid. It is structurally similar to cytidine, but has an additional methyl group. 2'-O-Methyl-5-methylcytidine stabilizes the conformational structure of nucleic acids and can be used to regulate the activity of enzymes. This modified nucleoside has been shown to have thermophilic characteristics when it interacts with human cells. The stability of 2'-O-Methyl-5-methylcytidine increases with increasing temperature, making it possible for this molecule to regulate gene expression in organisms that live at high temperatures.

3′-Guanylic acid disodium is a nucleoside analog that inhibits viral replication and tumor growth. It is an antiviral agent that is active against herpes simplex virus type 1 and type 2, as well as cytomegalovirus. 3′-Guanylic acid disodium is also an anticancer agent that has shown promising results in animal models of glioma, lymphoma, lung cancer, and breast cancer. The molecule inhibits the synthesis of DNA by competitively inhibiting the action of ribonucleotide reductase. 3′-Guanylic acid disodium also inhibits protein synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. This drug has been shown to have a high purity and quality with no detectable impurities or contaminants.

Guanosine 5?-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF). Guanosine 5?-Triphosphate, Disodium Salt is a phosphoryl donor in protein synthesis and in signal transduction. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Adenosine 5'-triphosphate disodium salt hydrate is a nanomaterial that is used as a research reagent in biochemical and cancer studies. It is also used for the detection of fatty acids, caffeine, and chemiluminescent assays. Adenosine 5'-triphosphate disodium salt hydrate has been shown to promote pro-inflammatory cytokines such as IL-6 and IL-8 secretion from macrophages. Adenosine 5'-triphosphate disodium salt hydrate can be used to measure the hydration level of cells by using a chemiluminescent assay. This assay detects adenosine triphosphate (ATP) production following ATP hydrolysis, which is catalyzed by the enzyme adenylate kinase.

9-(b-D-Arabinofuranosyl) guanine is a purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. 9-(b-D-Arabinofuranosyl) guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA causing cell death. It also has antineoplastic properties. 9-(b-D-Arabinofuranosyl) guanine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

2'-O-Methyl-5-propynylcytidine is an antiviral drug that inhibits the replication of retroviruses by competitive inhibition of the viral RNA polymerase. It has been shown to be effective against HIV, HSV and CMV. This drug also has shown anticancer activity in vitro and in vivo. 2'-O-Methyl-5-propynylcytidine has a novel mechanism of action and is used as a building block for oligonucleotide synthesis because it is resistant to degradation by nucleases.

Focuses is a chemical compound that does not have any known commercial or industrial uses.

6-(β-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one is a novel nucleoside that has been shown to have anticancer and antiviral properties. In vitro studies have shown the compound to activate both DNA and RNA synthesis in cells. The compound also inhibits the replication of HIV viruses. 6-(β-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one is synthesized from ribonucleosides or deoxyribonucleosides through phosphoramidite chemistry. This product is available in high purity and high quality.

7-Deaza-2',3'-dideoxy-7-iodoadenosine is a nucleoside analogue that is used as an antiviral, anticancer, and antifungal agent. It is a modified form of adenosine which inhibits viral replication by inhibiting the activity of reverse transcriptase. 7-Deaza-2',3'-dideoxy-7-iodoadenosine has also been shown to inhibit DNA synthesis in cells by blocking the incorporation of dCTP into DNA. This nucleoside analogue has shown potential for use as an activator in phosphoramidite chemistry and as a deoxyribonucleoside in oligonucleotide synthesis.

2'-Deoxy-5-propynyluridine is a nucleoside that is naturally synthesized in the body. It is an intermediate in the synthesis of pyrimidine nucleotides and has been shown to be useful for the treatment of cardiac arrhythmias. 2'-Deoxy-5-propynyluridine has also been found to have a stabilizing effect on RNA, enhancing its biological relevance. This compound can be used as a fluorescent probe and can be used to study transcriptional regulation mechanisms.

7-Deaza-2'-deoxy-7-iodoadenosine is an oligomer with a stabilized backbone that has been shown to inhibit the growth of bacteria in vitro. It binds to DNA and prevents RNA synthesis. 7-Deaza-2'-deoxy-7-iodoadenosine is a synthetic nucleotide analogue that is used as a probe for mapping RNA sequences and as an inhibitor of bacterial growth. This compound is also used in the synthesis of oligodeoxynucleotides because it has a high affinity for guanine residues, which can be incorporated into the oligonucleotide chain by chemical ligation. The octameric form of 7-deaza-2'-deoxyadenosine is most active against bacterial cells.

Gemcitabine is a prodrug that is converted to 5-fluorouracil (5FU) in the body. It has been shown to inhibit the growth of bladder and pancreatic cancer cells by interfering with the synthesis of DNA. Gemcitabine inhibits DNA replication by binding to the epidermal growth factor receptor, which leads to cell death. Gemcitabine also acts as a competitive inhibitor of deoxycytidine kinase, which prevents the formation of deoxycytidine monophosphate from deoxyuridine monophosphate, preventing DNA replication. In addition, gemcitabine can activate apoptosis in some tumor cells by increasing levels of intracellular free calcium, which leads to activation of enzymes such as phospholipases and proteases that degrade proteins, lipids, and nucleic acids.

Thymidine-5'-diphosphate-L-rhamnose disodium is a nucleoside that belongs to the class of modified nucleosides. It is a synthetic, modified thymidine with a phosphate group at the 5'-position and L-rhamnose at the 2' position. Thymidine-5'-diphosphate-L-rhamnose disodium has antiviral and anticancer activities, as well as high purity and high quality. This compound has been shown to inhibit HIV replication in vitro and in vivo. Thymidine-5'-diphosphate-L-rhamnose disodium is also used in the synthesis of DNA and RNA.

N6-Benzoyl-5'-O-DMT-adenosine is a synthetic nucleoside with antiviral activity. It is an activator of viral DNA polymerase and inhibits viral replication by inhibiting DNA synthesis in the host cell. N6-Benzoyl-5'-O-DMT-adenosine has shown anticancer activity in tumor cells, which may be due to its ability to inhibit ribonucleotide reductase and diphosphate kinase.

5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has been modified to contain the 2' methyl group at the 5' position. This modification enhances its anticancer activity and cellular uptake by cells. The 5'-O-DMT-2'-O-methylguanosine monophosphate synthesized in this study is chemically stable, high purity, and high quality.

N-(2'-Deoxy- 2', 2'- difluorocytidine 5'-P- phenyl phosphate) L- alanine benzyl ester, also known as Acelarin, is primarily used in cancer treatment, including leukemia and solid tumors.

2'-C-Methylguanosine 5'-diphosphate triethylammonium salt is a synthetic nucleotide analog for use in research

Universal sulfonate donor for in vivo sulfonation by sulfotransferases

3′-UMP is a modified nucleoside that has antiviral activity, and is synthesized by the phosphoramidite method. It is a novel compound, which has not been previously reported. 3′-UMP is an activator of ribonucleotide reductase and can be used to treat viral infections. This drug also has anticancer effects and can be used as a chemotherapeutic agent for the treatment of leukemia. 3′-UMP has high purity and high quality.

2'-Deoxyadenosine-5'-triphosphate disodium salt is a nucleotide that is formed from adenosine triphosphate (ATP) and deoxyadenosine monophosphate (dAMP). It is an intermediate in the biosynthesis of fatty acids, which are important components of cell membranes. This nucleotide can be used to measure the light exposure of bacteria. 2'-Deoxyadenosine-5'-triphosphate disodium salt has been shown to have antibacterial activity against some Gram-positive bacteria, such as Staphylococcus aureus. The effective dose for these bacteria is 5 µg/mL with a linear model. The biological properties of this nucleotide are still not fully understood, but it is thought to play a role in blood pressure regulation through its effects on fatty acid synthesis.

1,5-Anhydro-3-O-benzoyl-4,6-O-benzylidene-2-deoxy-2-(N4-benzoylcytidin-1-yl)-D-altro-hexitol is a synthetic nucleoside analog for use in research

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A potential role in apoptosis and cellular senescence.

UDP-N-azidoacetylgalactosamine (UDP-GlcNAz) is an analogue of UDP-GalNAc, bearing an azido group on the N-acyl side chain. It acts as an unnatural substrate for the polypeptide N-R-acetylgalactosaminyltransferases (ppGalNAcTs) which are enzymes that play a role in mucin-type O-linked glycoprotein biosynthesis. UDP-GlcNAz is accepted as a nucleotide-sugar donor, appending an azidosugar onto its native substrates, which can then be detected using azide-reactive chemical probes. The azide group can be detected by the conjugation with phosphine probes via the Staudinger ligation, or alkyne probes via cycloaddition reactions.

2'-Deoxy-N6-(2-hydroxyethyl)adenosine is a synthetic nucleoside that is used as a building block for the chemical synthesis of oligonucleotides. It is also an antiviral agent and has been shown to have anticancer properties. 2'-Deoxy-N6-(2-hydroxyethyl)adenosine is used in the manufacture of phosphoramidites, deoxyribonucleosides, and ribonucleosides. This product can be synthesized at high purity and quality, with CAS No. 137058-94-7.

2'-Deoxypseudoisocytidine is a synthetic nucleoside that is structurally similar to pseudoisocytidine. It is used as an anti-cancer agent in labeling studies. The compound exhibits cytotoxic activity against tumor cells and inhibits the growth of cultured human cancer cell lines. 2'-Deoxypseudoisocytidine has been shown to be effective in preventing the growth of brain tumors in mice by targeting DNA synthesis, which may be due to its ability to act as an analog of cytosine and bind to DNA. This drug also has potential for use as a chemotherapeutic agent for leukemia and other cancers.

It is used as a salt formulation of the essential metabolic compound adenosine diphosphate (ADP). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

N4-Methyl-2'-O-methyl-cytidine is a nucleoside analog that is used as an antibiotic. The ribosomal RNA in prokaryotes has been found to be sensitive to this drug, which inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosome and inhibiting translocation. N4-Methyl-2'-O-methyl-cytidine also binds to the ribonucleoprotein in eukaryotic cells, blocking translation of mRNA into proteins. N4-Methyl-2'-O-methyl-cytidine is effective against Gram positive bacteria, such as Staphylococcus aureus and Clostridium perfringens, while being inactive against Gram negative bacteria. This drug has a molecular weight of 197 and can be broken down into low molecular weight fragments or high molecular weight fragments.

Ent-abacavir is a drug that belongs to the group of antiretroviral drugs. It has minimal toxicity and has been shown to be effective in long-term treatment of HIV/AIDS. Ent-abacavir is also used as part of active antiretroviral therapy, which includes at least three or four different drugs. It inhibits the activity of reverse transcriptase, an enzyme involved in the replication process of HIV and other retroviruses. This drug has been shown to have few drug interactions with other medications, although caution should be taken when using ent-abacavir with drugs that are metabolized by cytochrome P450 enzymes. Ent-abacavir is not recommended for use in patients who have chronic viral hepatitis or who have a body mass index greater than 30 kg/m2 because its pharmacokinetic properties may be altered in these individuals.

Anticancer nucleoside; DNA synthesis interference

Uridine-2',3'-cyclic monophosphate sodium salt (CAS No. 15718-50-0) is a novel anticancer agent that has been shown to inhibit the growth of cancer cells in vitro and in vivo. It is a nucleoside analog that inhibits the synthesis of DNA by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase, two enzymes involved in the production of DNA. Uridine-2',3'-cyclic monophosphate sodium salt is also an antiviral agent used to treat herpesvirus infections, such as herpes simplex type 1 and 2. This drug binds to viral RNA polymerase, which prevents viral replication by preventing mRNA synthesis.

2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is a novel phosphoramidite nucleoside that is an antiviral and anticancer agent. It can be used as a monophosphate or diphosphate. 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine has been shown to inhibit the replication of DNA, RNA, and protein synthesis. This compound also has an activating effect on the immune system by inducing lymphocyte proliferation and increasing NK activity. It inhibits the growth of viruses such as HIV and influenza A virus. The purity of 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is high, with a CAS number of 11052282-2.

5-Chloro-2-pyridinecarboxylic acid methyl ester is a monophosphate nucleoside that can be used in the synthesis of DNA and RNA. It is also an antiviral, anticancer, and anticoagulant agent. 5-Chloro-2-pyridinecarboxylic acid methyl ester has been shown to inhibit DNA replication and transcription by inhibiting the activity of enzymes involved in these processes. It can be used as a building block for the synthesis of DNA and RNA. The purity of this product is high, with no detectable impurities at levels above 0.1%.

2',5'-Dideoxyadenosine is a nucleotide analog that inhibits the enzyme adenylate cyclase, by binding non-competitively via the P-site

Inosine 5'-triphosphate disodium salt is a phosphoramidite that can be used as an activator for DNA synthesis. It also has antiviral and anticancer properties. Inosine 5'-triphosphate disodium salt is used in the synthesis of deoxyribonucleosides and other nucleotides.

N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine is a novel nucleoside analog with antiviral, anticancer and immunomodulatory activities. It has been shown to inhibit the replication of HIV-1 and to induce apoptosis in tumor cells. N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine is a phosphoramidite that can be used for the synthesis of DNA, RNA, and deoxyribonucleotides. This product is synthesized by using an automated high purity process.

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2',5'-Dideoxycytidine is a nucleoside for use in a variety of applications

2',3'-O-Isopropylideneinosineis a nucleoside for use in research applications

4-Amino-2,6-dihydroxy-5-nitrosopyrimidine is a molecule that has been shown to be an effective inhibitor of the enzyme tyrosinase in the oxidation of tyrosine to DOPA, which is a precursor of melanin. It is believed that vibrational and structural changes during these reactions are responsible for the inhibitory effects. 4-Amino-2,6-dihydroxy-5-nitrosopyrimidine has also been shown to have anti cancer effects on glioma cells. This molecule binds to copper ions, forming a chelate ring that can stabilize reactive intermediates and terminate free radicals. The chlorine atom on this molecule may be responsible for its cytotoxic effects by reacting with nucleophilic sites on proteins. The functional groups on this molecule react with acid catalysts, such as protonation or dehydration reactions.

N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine is a novel nucleoside that is structurally related to adenosine. It is synthesized through the reaction of N6-benzoyladenine with 2'-O-methyladenosine. This nucleoside has been shown to be an effective antiviral and anticancer agent.

Adenosine 5'-diphosphate monosodium salt (ADP) is an adenine nucleotide which is phosphorylated into ATP by the enzyme ATPase. This phosphorylation is essential in cellular homeostasis due to its role in energy storage and nucleic acid metabolism. Adenosine 5'-diphosphate monosodium salt is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

2'-Deoxyinosine-5'-triphosphate sodium (2'-dITP) is a modified nucleotide that has antiviral and anticancer properties. It has been shown to be an activator for ribonucleosides, deoxyribonucleosides, and DNA. 2'-DITP has also been shown to inhibit the growth of human breast cancer cells in vitro.

3'-O-Benzoylthymidine is a nucleoside that is used in the synthesis of DNA. It is a monomeric compound that contains two deoxyribose sugars and one deoxyribonucleotide. 3'-O-Benzoylthymidine interacts with the phosphite triester, which stabilizes the nucleobase. This reaction leads to the formation of a glycosidic bond between the phosphate group and the 5' carbon atom in the sugar ring of 3'-O-benzoylthymidine. The chloride ion is then added to form an intermediate compound with a reactive electrophilic carbon center that can be used for subsequent reactions with other compounds or nucleobases. 3'-O-Benzoylthymidine can also be conjugated to other compounds through covalent bonds, such as phosphonates, to form more complex molecules.