Vitamins

Ercalcitriol, active Vitamin D2 metabolite, boosts immunity by regulating CAMP and DEFB4 genes against infections.

Impurity Cholecalciferol EP Impurity C Stability Light Sensitive, Temperature Sensitive Applications Lumisterol 3 (Cholecalciferol EP Impurity A) is an isomer of Vitamin D3 (V676045). Lumisterol 3 is used in the preparation of vitamin D analogs. References Yamamoto, J., et al.: Biochemistry, 24, 3338 (1985), Takagi, K., et al.: Crit. Rev. Biochem. Mol. Biol., 28, 323 (1993),

Stability Light Sensitive, Temperature Sensitive Applications A fatty acid ester of Retinol isomer, found mainly in the retina. References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),

Stability Light Sensitive, Hygroscopic Applications 25-Hydroxyvitamin D3 3-Glucuronide is an glucuronidated conjugate of 5-Hydroxyvitamin D3 (C125700), the principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator. References Higashi, T., et al.: Steroids., 65, 281 (2000); Shimada, K., et al.: J. Pharma. Biomed. Anal., 15, 1207 (1997);

Stability Light and Temperature Sensitive Applications Vitamin D2 analog.

Stability Light Sensitive, Temperature Sensitive Applications Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 9 is a form of vitamin K2 which acts as a prothrombogenic agent and is also a functional electron transfer component in nitrate reductase. References Hugenholtz, P., et al.: J. Bacteriol., 180, 4765 (1998), Ginet, N., et al.: Biochemistry, 40, 1812 (2001), Cape, J., et al.: J. Biol. Chem., 280, 34654 (2005),

Applications BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo. References (1) Berkovich, L., et al.: Anticancer Drugs. 21, 609 (2010) (2) Szabados, E., et al. Biochem Pharmacol. 59, 937 (2000)