Vitamins

6-Fluorovitamin D3 is a synthetic analog of vitamin D3, which is a modified form of the naturally occurring hormone known as cholecalciferol. This molecule is typically derived through chemical synthesis, incorporating a fluorine atom at a specific position on the vitamin D3 structure. The introduction of the fluorine atom is designed to enhance the stability of the compound and potentially alter its biological activity. The mode of action of 6-Fluorovitamin D3 involves interaction with the vitamin D receptor, a nuclear receptor that regulates the expression of genes involved in calcium and phosphate homeostasis, immune response modulation, and cellular differentiation. The fluorine substitution may influence the binding affinity and selectivity of this analog compared to the native hormone, offering insights into receptor-ligand dynamics and activation pathways. 6-Fluorovitamin D3 is primarily used in biochemical and pharmacological research. It serves as a valuable tool for studying the structure-activity relationships of vitamin D metabolites and their analogs. Researchers leverage this compound to explore its potential effects on cellular processes, with implications for understanding diseases related to vitamin D3 metabolism and receptor interactions.

Applications A labelled metabolite of Nicotinamide. References Musfeld, C., et al.: J. Pharm. Biomed. Anal., 24, 391 (2001), Sakakibara, Y., et al.: Brain Res., 931, 68 (2002), Zielonka, J., et al.: Chem. Res. Toxicol., 19, 668 (2006), Wieczorkowska, M., et al.: Pharmacol. Rep., 59, 216 (2007),

Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote

Stability Light Sensitive, Temperature Sensitive Applications Bioactive, synthetic vitamin D3 analog; exhibits antiproliferative effect on keratinocytes. Antipsoriatic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Matsunaga, T., et al.: J. Dermatol., 17, 135 (1990), Gerritsen, M.J.P., et al.: Br. J. Dermatol., 131, 57 (1994),

Cholecalciferol - 100IU/mg - contains 2.5g/kg active is a chemical compound known as vitamin D3. It is derived primarily from cholesterol through photochemical synthesis in animal skin exposed to ultraviolet light. The product functions as a hormone regulator by modulating calcium and phosphorus metabolism within biological systems. This process is crucial for maintaining bone density and immune system efficacy. Cholecalciferol is extensively used in scientific research to explore its role in bone health, immune response modulation, and potential therapeutic applications for various diseases such as osteoporosis and autoimmune disorders. Its efficacy in these areas makes it a valuable tool for furthering understanding in endocrinology and pharmacology. Researchers often utilize this compound in in vitro and in vivo studies to elucidate molecular mechanisms and develop new therapeutic strategies.

Edible preparations, not canned or frozen, not containing cane and/or beet sugar, nesoi

Biotin is a water-soluble vitamin, also known as vitamin B7. Biotin is an essential coenzyme for five carboxylases in mammalian cells, which play key roles in the metabolism of glucose, amino acids and fatty acids (Zempleni, 2014). Biotin is also used in biochemistry in affinity purification of proteins in the biotin-avidin and biotin-streptavidin systems. Herein, free biotin is used in the elution step to release the recombinant protein from the resin (Diamandis and Christopoulos, 1991).

Other vitamins and their derivatives, nesoi