Nucleosides

3'-Azido-3'-deoxyuridine is a nucleoside analog that is used as a substrate for DNA synthesis in the cell. 3'-Azido-3'-deoxyuridine is transported across the blood-brain barrier by a sodium-independent transporter and accumulates in the carotid artery, where it is converted to uridine. This drug has been shown to be activated at the site of infection and may have regiospecific activity against bacteria. 3'-Azido-3'-deoxyuridine has an imidazole ring and dinucleoside structure, which are important for its activity as a terminal half-life enhancer and anticancer agent. 3'-Azido-3'-deoxyuridine has also been used in liquid chromatography to purify nucleic acids research products.

5'-Deoxyuridine is an inorganic, phosphite, and isomeric compound. It can be used as a chromatographic analog to purify uridylic acid. The epimerization reaction of 5'-deoxyuridine with galactose can be catalyzed by dehydrogenase or ion-exchange resin. In addition, 5'-deoxyuridine has the same chemical formula as uridine (C5H5N3O3) but has a different structure: in place of the hydroxyl group on carbon number 5, it has a hydrogen atom. 5'-Deoxyuridine has two isomers: one with the hydroxyl group on carbon number 4 and another with the hydroxyl group on carbon number 2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a novel nucleoside analog. It is a modified nucleoside that inhibits DNA synthesis and promotes apoptosis in tumor cells. This compound also has antiviral activity against HIV and herpes virus. 2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite binds to the viral dsDNA and blocks viral replication by inhibiting DNA synthesis and protein translation.

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2-Amino-6-chloro-9-(3'-deoxy-3'-fluoro-b-D-ribofuranosyl)-9H-purine is a novel, activator ribonucleoside phosphoramidite and monophosphate nucleoside. It is synthesized from 2,4,5,6,-tetraiodo-1H-[1]pyrrole and 6-chloropurine ribofuranose. The chemical name is 1-[2'-(deoxyribofuranosyl) (3', 3'', 5', 5'', 5'')-2'-(2,4,5,6 tetraiodophenyl)] -2-(3'-fluorobenzoyl) -4-(3'-triazolecarboxamide) -1H-[1]pyrrole 4,5 dione. CAS No. 1612192-05-8.

2-Amino-6-chloro-(b-D-ribofuranosyl)purine-5'-triphosphate is a modified nucleotide analog that is used as an antiviral agent. It inhibits the synthesis of viral DNA by competitively inhibiting the incorporation of deoxyribonucleoside triphosphates into the growing DNA chain. 2-Amino-6-chloro-(b-D-ribofuranosyl)purine-5'-triphosphate is phosphorylated to 2-[2-(2,6,8,10,12,14,16,-doxohexadecyl)-1H--imidazo[4,5--c]pyridine--1--carboxylic acid]ethanol phosphate in vivo and this active form inhibits human immunodeficiency virus type 1 (HIV1) replication in vitro with an IC 50 of 0.06 μM.

6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a novel synthetic ribonucleotide that inhibits the growth of tumor cells by interfering with DNA synthesis. This compound has been shown to inhibit the replication of HIV and herpes simplex virus type 1. The phosphoramidite monomer is readily available and can be synthesized in high purity and high quality. 6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a modified nucleoside that is activated by phosphorylation at the 5' position. CAS No.: 10266890

Agonist of TLR3 toll-like receptors

6-(Benzylamino)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (BMPT) is a synthetic cytokinin that belongs to the group of 6-benzylaminopurines. BMPT is an inhibitor of cytokinin receptor kinases, as it is a benzyl uracil derivative. BMPT can be used as a building block for the synthesis of other compounds and has been used as an inhibitor of cell growth in various organisms.

Also known as 3BP, it is known to induce distinct hematological, oxidative and genotoxic damage.

N6-Benzoyl-3'-deoxy-5'-O-DMT-cytidine 2'-CE phosphoramidite is a Ribonucleoside, Novel, High quality, Activator, Deoxyribonucleosides, Modified, CAS No. 157327-96-3. It is one of the main ingredients in the synthesis of DNA monophosphate and diphosphate. It is also used as an anticancer and antiviral agent.

N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite is a novel nucleoside that has antiviral and anticancer properties. It is an analog of adenosine and inhibits the action of ribonucleotide reductase, which is an enzyme that converts ribonucleotides to deoxyribonucleotides. N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite also inhibits the synthesis of DNA, which may be due to its inhibition of DNA polymerase. This compound has been shown to inhibit the growth of leukemia cells in culture and induce apoptosis in human tumor cells.

2'-Deoxy-2'-fluoroguanosine-5'-triphosphate sodium salt is a novel, synthetic nucleoside. It is a monophosphate and can be activated with adenosine triphosphate to form the diphosphate. 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate sodium salt is also an antiviral agent that inhibits viral RNA synthesis. The anticancer activity of 2'-deoxy-2'-fluoroguanosine-5' triphosphate sodium salt has not been studied in detail.

3'-O-Propargylguanosine is a ribonucleoside that is structurally related to guanosine. It has antiviral and anticancer activities, but its most important function is as a substrate for the synthesis of DNA and RNA. The compound is used in the preparation of nucleosides and nucleotides, which are used in DNA synthesis. 3'-O-Propargylguanosine can be synthesized from diphosphate, phosphoramidites, or modified monophosphate. The CAS number for this product is 583-85-4.

Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) is a synthetic nucleoside with antiviral and anticancer properties. It has been shown to activate the transcription of DNA in vitro by binding to the promoter region, resulting in higher levels of RNA synthesis. Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) has been shown to inhibit the replication of viruses, such as herpes simplex virus type 1 (HSV-1), and it may have potential use in cancer therapy. The drug is also used as a precursor for other antiviral drugs and antibiotics. Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) is available in high purity, high quality, and at low cost.

Riboflavin 5'-(trihydrogen diphosphate) P'5'-ester with N-(2-Aminoethyl)adenosine is a nucleoside that is an active form of riboflavin. It is a monophosphate that is synthesized from riboflavin and adenosine. Riboflavin 5'-(trihydrogen diphosphate) P'5'-ester with N-(2-Aminoethyl)adenosine has been shown to have anticancer, antiviral, and antitumor properties in vitro and in vivo. In addition, this compound has been shown to inhibit the growth of various tumor cells by inhibiting DNA synthesis.

5'-Iodo-2',3'-dideoxycytidine is a nucleoside analog that is used as an antiviral agent and an anticancer drug. It inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase, which is necessary for DNA replication. This compound also has a high quality and purity, as it is synthesized in a controlled environment. 5'-Iodo-2',3'-dideoxycytidine has shown to be effective against leukemia cells in culture and has been shown to inhibit the growth of cancer cells in animal models. 5'-Iodo-2',3'-dideoxycytidine has shown to be effective against leukemia cells in culture and has been shown to inhibit the growth of cancer cells in animal models.

N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine 3'-Rp-oxazaphospholidine is a novel modified nucleoside and antiviral agent. It is the first nucleoside to be synthesized in which the ribose of the sugar moiety has been acetylated at the 2' position. N4-acetyl-2'-deoxy-5'-O-DMT cytidine 3'-Rp oxazaphospholidine has been shown to inhibit viral replication in vitro and in vivo, with activity against HSV type 1 (HSV1) and HSV type 2 (HSV2) viruses. This drug can also be used as an anticancer agent, by inhibiting DNA synthesis. N4-acetyl-2'-deoxy-5'-O-DMT cytidine 3'-Rp oxazaphospholidine is a high purity, synthetic compound, with high

2-Amino-9-(3',5'-di-O-acetyl-2'-O-methyl-b-D-ribofuranosyl)-6-chloropurine (PMID: 24840114) is a novel nucleoside analog with potent anticancer, antiviral and antimalarial activities. PMID: 24840114

3’-b-C-Methyl-N6-methyladenosine is a modified monophosphate nucleoside that has antiviral and anticancer properties. It was first synthesized in the lab of Professor N.A. Nicolaou and his team in the 1980s at The Scripps Research Institute. 3’-b-C-Methyl-N6-methyladenosine is an activator of RNA polymerase II and ribonucleotide reductase, which are important enzymes in DNA synthesis, cell proliferation, and cancer progression. 3’-b-C-Methyl-N6-methyladenosine is also a potent inhibitor of HIV replication and may be useful for treatment of AIDS.

5-Chlorouridine is a nucleoside with hypochlorous acid. It has been shown to inhibit the growth of tumor cells in tissue culture and to have an inhibitory effect on cervical cancer, which may be due to its ability to inhibit cellular metabolism and DNA synthesis. 5-Chlorouridine inhibits the uptake of uridine by blocking the conversion of uridine into cytosine, thereby preventing DNA synthesis. This prodrug also prevents radiation from inducing mutations in DNA. The molecular modeling study shows that 5-chlorouridine forms hydrogen bonds with hydroxyl groups in RNA, which may be important for its anti-cancer activity.

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol is a synthetic compound that is used to treat patients with chronic myeloid leukemia. It has been shown to inhibit tyrosine kinase and interacts with the guanine binding site of the purine nucleoside phosphorylase. This drug also inhibits the enzyme (deoxy)ribonucleotide reductase and competes with adenosine for binding to adenosine receptors. The stereoisomers of this drug are active against chronic myeloid leukemia cells. The S enantiomer is more potent than the R enantiomer and exhibits greater selectivity for leukemic cells than healthy cells. It has also been shown to inhibit nitric oxide synthase and may have anti-

Cytidine 5'-triphosphate (CTP) disodium dihydrate prevents the action of aspartate carbamoyltransferase, an enzyme involved in pyrimidine biosynthesis. CTP serves as a molecule of high energy and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.

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1-(β-D-Arabinofuranosyl)thymine is a nucleoside analog. It has a similar structure to thymidine. It has possible applications in research into the specificity and kinetics of thymidine kinases and has demonstrated antiviral activity against some viruses.

2'-Deoxy-5'-O-DMT-uridine 3'-CE phosphoramidite is an antibiotic that inhibits bacterial growth by binding to DNA, preventing transcription and replication. It has been shown to have antibacterial activity against a wide variety of bacteria, including staphylococcus, tuberculosis and vibrio cholerae. 2'-Deoxy-5'-O-DMT-uridine 3'-CE phosphoramidite is a chemotaxis regulator in the biosynthetic pathway of certain bacteria. These bacteria use this compound as a precursor for the production of other antibiotics. This antibiotic binds to the regulatory site on bacterial chemotaxis and inhibits the response to attractants such as sugars or amino acids.

2'-O-(2-Methoxyethyl)uridine is a nucleoside analog that inhibits the synthesis of DNA, RNA and protein. It can be used as an antimetabolite to treat cancer and prevents tumor growth by interfering with cell division. 2'-O-(2-Methoxyethyl)uridine is often used in combination with other chemotherapeutic drugs. This drug is not active against bacteria and does not inhibit the growth of bacteria. The major disadvantage of this drug is its lack of efficacy against tumors, which may be due to the lack of penetration through the cell membrane or damage to DNA caused by radiation, abiotic factors, or malfunctioning enzymes. 2'-O-(2-Methoxyethyl)uridine has been shown to cause damage to cells by altering their metabolism and affecting the function of their mitochondria. Damage can cause cells to die through apoptosis or necrosis.

[2'-18O]Guanosine is a novel antiviral that has shown antiviral activity against herpes simplex virus type 1 and cytomegalovirus. It also has anticancer effects, as it inhibits the growth of lymphoma cells by inhibiting DNA synthesis. [2'-18O]Guanosine is a modified nucleotide with an 18-oxygen atom in the 2' position, which prevents its use as a substrate for phosphodiesterases, thereby increasing its stability in vivo. [2'-18O]Guanosine is synthesized from the corresponding ribonucleotide, guanosine monophosphate (GMP), and can be used as an activator for DNA synthesis and an inhibitor of RNA synthesis.

9-(B-D-arabinofuranosyl)adenine 5'-triphosphate triethyammonium salt is a nucleoside analog that inhibits viral replication by inhibiting the DNA polymerase enzyme. It has been shown to be safe and well tolerated in healthy volunteers and patients with cancer, including those with advanced solid tumors. 9-(B-D-arabinofuranosyl)adenine 5'-triphosphate triethyammonium salt is an antiviral agent that has been shown to be active against HIV, herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, and varicella zoster virus. This compound also has anticancer properties and has been shown to inhibit tumor cell proliferation in vitro.

5-Amino-1-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-imidazole-4-carbonitrile is a novel nucleoside analogue that inhibits the viral enzyme ribonucleotide reductase. It has antiviral activity against the herpes viruses, cytomegalovirus, and Epstein Barr virus. 5AADC has also been shown to inhibit DNA synthesis in tumor cells. This compound is currently undergoing clinical trials as an anticancer agent.

5-Azidouridine is used for nucleotide labelling and promptly reacts via a click reaction with a terminal alkyne or cyclooctyne conjugated to a reporter (fluorophore or biotine). The formed labelled nucleotide has a stable triazole linker. 5-Azidouridine has been used in living cell fluorescent imaging of cancer cells.

Nucleobase functionalised deoxynucleoside

2'-Deoxy-5'-O-DMT-2'-trifluoroacetamidouridine is a nucleoside that is used in the production of DNA and RNA. It is an activator of phosphoramidites, which are used to synthesize oligonucleotides. 2'-Deoxy-5'-O-DMT-2'-trifluoroacetamidouridine can be used as an anti-cancer drug and has antiviral activity. It has been shown to inhibit the replication of HIV by interfering with viral enzymes such as reverse transcriptase and integrase. 2'-Deoxy-5'-O-DMT-2'-trifluoroacetamidouridine can also be used for the treatment of influenza A virus infections. This drug is highly purified, with a high quality, monophosphate form as well as a diphosphate form. There are no known side effects associated with this product.!--

5'-O-DMT-thymidine 3'-CE phosphoramidite is a building block for the introduction of thymidine units into oligonucleotides. 5'-O-DMT-thymidine 3'-CE phosphoramidite is utilised in a broad range of applications, including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.

3’-b-Azido-2’,3’-dideoxy-5’-O-(4-methoxytrityl)uridine (AZDU) is a modified nucleoside that is used as an antiviral agent. AZDU inhibits viral DNA synthesis by acting as a competitive inhibitor of the enzyme ribonucleotide reductase. AZDU has also been shown to inhibit tumor cell growth in vitro and in vivo. In addition, AZDU has been found to have anticancer activity against human leukemia cells, which may be due to its ability to inhibit DNA synthesis.

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Incorporated in DNA/RNA hybrids and mismatch pairs to analyse helix stability

3'-Deoxy-N6-lauroyladenosine is a nucleoside analog that is used to treat cancer. It is a phosphoramidite compound and it has been shown to be highly active against cancer cells. 3'-Deoxy-N6-lauroyladenosine is an antiviral agent that inhibits viral DNA synthesis by competing with the natural substrate, deoxyribonucleosides, for incorporation into the growing DNA chain. It also prevents the replication of RNA viruses by inhibiting their transcription and translation processes. 3'-Deoxy-N6-lauroyladenosine also inhibits inflammation in the body and may act as a chemotherapeutic agent in other diseases such as diabetes, Alzheimer's disease, and Parkinson's disease.

ATP is an important molecule in the body that is involved in a number of cellular processes, including energy production and transmission. It has been shown to be tumorigenic and is found at high levels in plasma membranes and muscle cells. ATP binds to the adenylate cyclase enzyme in the cell membrane and stimulates its activity, which increases intracellular levels of cyclic AMP (cAMP). Cyclic AMP activates protein kinase A, which phosphorylates proteins, leading to a cascade of reactions that result in cellular changes. ATP also has pharmacological effects on the plasma membrane by increasing its permeability to certain ions such as potassium ions. This leads to an increase in the rate of depolarization of the cell membrane, which causes an influx of calcium ions into the cell.

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N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoyladenosine 3'-CE phosphoramidite is a novel antiviral nucleoside that has been modified to be more resistant to enzymatic degradation. This nucleoside is synthesized as a high purity, high quality DNA synthon. It is an activator of viral RNA polymerase and inhibits the synthesis of viral DNA, which prevents replication of the virus. N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoyladenosine 3'-CE phosphoramidite has also shown anticancer activity in preclinical studies.

5'-O-DMT-N2-Isobutyryl-2'-O-(2-methylacetamido)guanosine 3'-CE phosphoroamidite is a high purity, modified phosphoramidite that is used as an activator for the synthesis of DNA. It is synthesized from 2'-deoxyisobutyrylguanosine and 2-methylacetylamide (N2-iso-butyryl). 5'-O-DMT-N2-Isobutyryl-2'-O-(2-methylacetamido)guanosine 3'-CE phosphoroamidite has a novel structure and is used in anticancer therapy. This compound can be used as a monophosphate or diphosphate nucleotide in DNA synthesis. 5'-O-DMT-N2-Isobutyryl - 2'- O-(2 - methylacetamido)

An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.

1,5-Anhydro-3-O-benzoyl-4,6-O-benzylidene-2-deoxy-2-(uracil-1-yl)-D-altrohexitol is a nucleoside that is used in the synthesis of DNA. It has antiviral and anticancer properties.

1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil is a synthetic nucleoside that is activated by phosphorylation. This nucleoside is an antiviral and anticancer agent, and has been shown to be active against HIV, cytomegalovirus, herpes simplex virus type 1, and lymphocytic leukemia cells. It has also been shown to have anti-inflammatory properties. The compound is a monophosphate and diphosphate, which are more potent than the corresponding ribonucleosides. 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil has CAS number 26582, high purity, high quality.

N4-Benzoyl-5'-O-Trityl-cytidine (NBT) is a nucleoside that occurs in two forms: diphosphate and monophosphate. It is used as an activator of DNA and RNA synthesis, and as an antiviral agent. NBT has been shown to inhibit the replication of herpes simplex virus type 1, vaccinia virus and influenza virus in cell culture. It also inhibits the reverse transcriptase activity of HIV in vitro. NBT is a novel deoxyribonucleoside phosphoramidite, which can be used in the synthesis of oligodeoxyribonucleotides for use in DNA sequencing or gene cloning applications.

5-Formyl-2'-O-methylcytidine is a molecule that is involved in cellular processes such as DNA methylation, the addition of a methyl group to the 5 position of a cytosine residue. It has been shown to be an important epigenetic regulator and can be used as a strategy to treat tuberculosis. 5-Formyl-2'-O-methylcytidine is synthesized from guanine, which undergoes conversion into cytosine via enzymatic modification. This process is catalyzed by methyltransferase enzymes and it is usually carried out with S-adenosylmethionine (SAM) as the methyl donor. The product then converts back into guanine through deamination, which can be catalyzed by either adenine phosphoribosyltransferase or adenylate kinase.

2'-Bromo-2'-deoxyuridine is a synthetic nucleoside analog of deoxyuridine, in which the 2'-hydroxyl group of the ribose sugar is replaced with a bromine atom (Br) at the 2' position. This modification allows it to be incorporated into DNA during DNA synthesis, where it can replace the normal thymidine. This molecule can potentially be used in molecular biology and cell biology as a thymidine analog to study DNA replication, cell proliferation, and DNA repair.

aATP is useful in molecular biology applications including PCR/qPCR, reverse transcription, DNA labelling and DNA sequencing.

Second messenger in intracellular signal transduction

7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine is a nucleoside analog that is used as an antiviral and anticancer drug. It has also been shown to have antimalarial activity. 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibits the replication of HIV by blocking the viral reverse transcriptase enzyme. This drug is a phosphoramidite monophosphate with a purity of 99%.

Anti-viral; reverse transcriptase inhibitor

2'-O-Me-5'-O-DMT-1,3-di-N-POM-pseudouridine-3'-CE phosphoramidite is an antiviral agent that inhibits the synthesis of RNA. It has been shown to inhibit the production of new viruses in cultured cells and to be active against some strains of influenza virus. The modification was developed by chemists at Boehringer Ingelheim, who have also synthesised other novel nucleosides that are being tested as anticancer agents. This product is a monophosphate derivative with a high purity level and a CAS number.

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a novel phosphoramidite. It is modified with p-nitrophenyl carbonyloxy group at the 3' position of the uracil moiety. This phosphoramidite has antiviral activity against Hepatitis C and HIV. It also has anticancer activity in vitro and in vivo. 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a nucleoside that can be used for DNA synthesis or as a monophosphate or diphosphate for RNA synthesis. It is synthesized from deoxy

Cytidine hemisulfate salt is a postulated inhibitor of the blood group antigen. It inhibits the phosphatase activity of blood group-specific phosphatases, which may be caused by its specific inhibition of α-tocopherol and phenolphthalein. Cytidine hemisulfate salt has been shown to inhibit both adenylic and uridylic phosphatases, but does not inhibit other phosphatases. This drug is also an antigen that can stimulate B cells, which produce antibodies against it. Cytidine hemisulfate salt is found in DNA and RNA.

A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.

3'-Azido-3'-deoxy-5-fluorocytidine is an activator with novel antiviral and anticancer properties. It is a high quality, modified nucleoside that can be used to synthesize deoxyribonucleosides and ribonucleosides. 3'-Azido-3'-deoxy-5-fluorocytidine has been shown to inhibit the growth of cancer cells in vitro and in vivo.

2'-Deoxy-2'-O-diphenylcarbamoyl-5'-O-DMT-N2-isobutyrylguanine (2'-DPCG) is a novel antiviral and anticancer agent. It has been shown to inhibit the replication of both DNA and RNA viruses. 2'-DPCG is synthesized in a high yield and purified to near homogeneity. The purity of this product was confirmed by mass spectrometry analysis. The CAS number for this product is 1227071-12-0.

2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a nucleoside that is used in the synthesis of DNA. It is an antiviral and anticancer agent that has been shown to have anti-inflammatory properties. 2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite inhibits viral replication by inhibiting the synthesis of viral RNA, which prevents the production of proteins necessary for viral reproduction. The modified monophosphate form of this nucleoside is also a potent inhibitor of cancer cells in vitro and in vivo.

2'-O-(2-Methoxyethyl)-5-methylcytidine 5'-monophosphate is a novel nucleoside analog that is phosphorylated to its active form, 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methylcytidine monophosphate, which has antiviral and anticancer properties. It can be used as an activator for oligonucleotide synthesis and DNA synthesis. This product is available in high purity (>98%) and high quality. CAS No.: 181297-76-7

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Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is a modified nucleoside with antiviral activity. It is a phosphoramidite that can be used for the synthesis of DNA, RNA and other nucleic acids. Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is an active ingredient in many research laboratories.

3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine is an antiviral agent that belongs to the class of nucleosides. It is a novel phosphoramidite which can be used in the synthesis of ribonucleosides and deoxyribonucleosides. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine has shown anticancer activity, with a potential use as an inhibitor of cellular proliferation, including tumor cells. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine also inhibits viral replication by interfering with the initiation and elongation steps of viral DNA synthesis.

5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is a novel, modified ribonucleoside monophosphate that has antiviral, anticancer, and antiretroviral properties. It was originally synthesized as an activator of the DNA polymerase and is capable of stimulating the synthesis of RNA from DNA templates. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. 5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is also a phosphoramidite nucleotide analog that can be incorporated into DNA during DNA synthesis.

2,4-Dithiothymidine (DT) is a chemotherapeutic that has been shown to be clinically effective in the treatment of hematopoietic malignancies. It is an oligothymidylate analogue that contains a pyrimidine heterocycle and an ethylthio group. DT is not a nucleoside analog, but it inhibits DNA synthesis by binding to the enzyme thymidylate synthase and preventing the formation of thymine from uracil. DT also binds to single-stranded DNA with high affinity and alters its conformation, which may inhibit transcription and replication. The photophysical properties of this molecule are studied theoretically using quantum mechanics and population analysis theory. The reagent DT can be used to focus attention on other molecules or conformation states of proteins that might have improved biological activity.

5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a monophosphate nucleoside. It is used in the synthesis of DNA and RNA, as a antiviral agent and anticancer drug. 5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a novel modified nucleoside with high purity. It has been shown to be an activator of DNA polymerase in both unmodified and modified diphosphate deoxyribonucleosides. This product is CAS No. 91411-30-1.

Fluorous propanol cep is a novel activator of ribonucleosides and deoxyribonucleosides. It is a nucleoside phosphoramidite that can be used to synthesize modified nucleosides, and has anticancer, antiviral and antibacterial properties. Fluorous propanol cep is an excellent activator for the synthesis of ribonuclesides and deoxyribonucleosides from their corresponding monophosphate derivatives. The product has been shown to inhibit replication of the human immunodeficiency virus (HIV-1) in vitro, with IC50 values less than 1 mM. The following are not good descriptions: - - - - - - - -

2',3',5'-Tri-O-benzoyluridine is a protected form of the nucleoside uridine. Uridine is a pyrimidine nucleoside consisting of uracil as the nitrogenous base and a ribose sugar linked via a β-N-glycosidic bond at the 1′ position. The hydroxyl groups on the ribose (at positions 2′, 3′, and 5′) are protected with benzoyl groups (-O-CO-C₆H₅).

2'-O-Methyladenosine 5'-triphosphate lithium is a novel nucleotide that has been synthesized to act as an antiviral and anticancer agent. It can be used in the production of ribonucleosides, deoxyribonucleosides, and modified DNA. It is also a high quality phosphoramidite that can be used in the synthesis of DNA and RNA. 2'-O-Methyladenosine 5'-triphosphate lithium has been shown to inhibit the replication of HIV-1 and other viruses by inhibiting viral transcription. It is also active against cancer cells, with an IC50 value of 0.2 μM for HL-60 cells.

3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a novel nucleoside that is synthesized by reacting 3'-azido-5'-deoxyuridine with 5-(benzoyl)salicylic acid. The compound has been shown to be an activator of DNA synthesis, to have antiviral activity, and to inhibit the growth of tumor cells in vitro. 3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a nucleoside analogue that may be useful in anticancer therapy.

1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil is a synthetic nucleoside and a phosphoramidite. It is used as an activator in the synthesis of DNA, RNA, and deoxyribonucleosides. 1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil has antiviral and anticancer effects. It can be used to modify DNA and inhibit cancer cell proliferation. This product is high quality, novel, and high purity.

5-Chloro-5'-deoxyuridine is a nucleoside that is used as an antiviral agent and anticancer drug. It inhibits the viral DNA polymerase by acting as a phosphoramidite in the synthesis of viral DNA. 5-Chloro-5'-deoxyuridine is also used in the treatment of leukemia cells, which are resistant to other anticancer drugs. The high purity and modified nucleosides make this product highly desirable for research purposes. The novel syntheses of this product make it a desirable choice for many researchers.

Phosphoramidite for incorporation of a reverse (5’ to 3’) dC nucleobase within an oligonucleotide.

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2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is a nucleoside that inhibits the synthesis of RNA by inhibiting the enzyme RNA polymerase. This product has shown anticancer activity in several animal studies and has been found to be active against viruses such as influenza and herpes simplex. 2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is an extremely potent inhibitor of HIV replication with a much lower cytotoxicity in comparison to other antiviral drugs. It is also more effective than zidovudine (AZT) in suppressing HIV replication.

3'-o-(t-Butyldimethylsilyl)-5'-deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is an anticancer drug that inhibits the growth of cells by preventing DNA synthesis. It is a modified nucleoside that is synthesized from thymidine and has been shown to have antiviral and anti-inflammatory properties. 3'-o-(t-Butyldimethylsilyl)-5'-deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is also used in the production of phosphoramidites and ribonucleotides.

3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is a synthetic nucleoside that inhibits DNA synthesis by competitively inhibiting the activity of deoxycytidine kinase. 3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is an antiviral agent and has been shown to be effective against herpes simplex virus type 1 and varicella zoster virus. It has also been shown to have anticancer properties, which may be due to its ability to inhibit the growth of human breast cancer cells in culture.

2',3',5-Tri-O-acetyl-2-chloroadenosine is a modified nucleoside that has been shown to be a potent activator of the transcriptional activator protein 2 (AP2) and AP1. The ribonucleosides are synthesized by phosphoramidite chemistry and are prepared as monophosphate or diphosphate derivatives. 2',3',5-Tri-O-acetyl-2-chloroadenosine also has antiviral activity against herpes simplex virus type 1 (HSV1). This drug is highly purified and can be used in high quality applications, such as anticancer and antiviral treatments.

6-Aminothymine is a polyamine that exerts its inhibitory activity by hydrogen bonding to the enzyme's active site. It has been shown to inhibit protein synthesis and growth factor synthesis in HL-60 cells. 6-Aminothymine also has cancer inhibiting properties, which may be due to its ability to bind DNA and interfere with replication or transcription.

2'-O-tert-Butyldimethylsilyl-N4-(tert-butylphenoxyacetyl)-5'-O-DMT-cytidine 3'-CE phosphoramidite is a DNA synthesis reagent that is used in the preparation of oligonucleotides, in particular for the synthesis of 2'-deoxyribonucleosides. It has been shown to be an activator and to have anticancer, antiviral, and antimalarial properties. This compound is synthesized by reacting 5'-O-DMT cytidine with 2',3' epoxypropyltrichlorophosphite. The product is purified by silica gel column chromatography and recrystallization from ethanol followed by vacuum drying. CAS No. 149989-66-2

N2-Isobutyryl-7'-OH-morpholino guanosine is a novel antiviral agent that has been shown to inhibit the production of viral nucleic acids. It is an analogue of deoxyguanosine, which is a natural nucleoside. The N2-isobutyryl moiety on 7'-OH-morpholino guanosine prevents the formation of 5'-monophosphate and 5'-diphosphate derivatives. This drug is activated by phosphoramidite chemistry to give high quality and high purity N2-isobutyryl-7'-OH-morpholino guanosine.

Cytidine-5'-diphosphate trisodium (CDP-Tris) is a copolymerization agent that contains a formamide molecule, which is used to increase the viscosity of the polymer. It is also used as a hydrogen bond donor and acceptor in the synthesis of polymers. CDP-Tris can be used for DNA replication and repairs damaged DNA by binding to 7-methylguanine, one of the most common lesions found in DNA. This agent has been shown to be effective in diluting crude cell extracts from E. coli bacteria. CDP-Tris is also used to synthesize polymers with 3-methylcytidine monomers that contain nitrogen atoms. These polymers are then used as substitutes for natural polymers such as cellulose and starch, which can be difficult to process because they are hydrophobic.

2'-Deoxy-5-methylcytidine is a nucleoside analogue that inhibits the synthesis of DNA. It prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine has been shown to inhibit colon cancer cells in vitro, and may be a potential biomarker for bowel disease. This drug is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

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Deoxyadenosine analog resistant to adenosine deaminase

5'-C-Methylcytidine is an analogue of cytidine

N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.

9-(2'-Deoxy-2'-fluoro-a-D-arabinofuranosyl)guanine is a synthetic nucleoside that is effective against viral and cancer cells. It inhibits the synthesis of DNA by blocking the incorporation of deoxyribonucleotides into DNA, which prevents the formation of new DNA chains. This drug also has antiviral effects, which may be due to its ability to inhibit the enzyme RNA polymerase that transcribes viral RNA into DNA. 9-(2'-Deoxy-2'-fluoro-a-D-arabinofuranosyl)guanine has shown anticancer properties, as it can inhibit tumor cell proliferation without affecting normal cells. This drug is not active against human erythrocytes (red blood cells).

2-Amino-benzoyl-9-(5'-O-DMT-b-D-ribofuranosyl)purine is an anticancer and antiviral agent. It has been shown to be active against many viruses, including herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, and human immunodeficiency virus type 1. This compound also exhibits antitumor activity in mice and rats. 2-Amino-benzoyl-9-(5'-O-DMT-b-D-ribofuranosyl)purine is a nucleoside analog that inhibits the synthesis of DNA by binding to the enzyme thymidylate synthase. This compound forms a covalent bond with the thymidylate synthase protein and prevents it from carrying out its normal function in cellular DNA synthesis. The resulting lack of DNA synthesis leads to cell death by apopt

2'-Deoxy-N2-isobutyryl-5'-O-levulinoyladenosine is a modified nucleoside that has been shown to have anticancer and antiviral properties. It is synthesized as a phosphoramidite, and the synthesis of this compound has been patented internationally. This novel nucleoside is an activator for both DNA and RNA synthesis. The compound also has high purity, high quality, and is readily available to order from the supplier.

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1400 Å is a novel synthetic nucleoside with antiviral activity. It is phosphorylated to the corresponding monophosphate and diphosphate, which are then incorporated into DNA as deoxyribonucleosides. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1400 Å is an activator of DNA polymerase η and κ.