Nucleosides

N2-Ethyl-2′-deoxyguanosine is an important metabolite of N2-ethyl-3′,5′-dideoxyadenosine (NEDA) and has been detected in urine samples from Sprague-Dawley rats. The biological properties of this metabolite are not well understood, but it has been shown to have genotoxic effects in mammalian cells and to be carcinogenic in a rat model. N2-Ethyl-2′-deoxyguanosine is also able to enhance the repair of damaged DNA and has functional groups that are similar to those found in cancer cells.

N2-DMF-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite is a nucleoside analog that inhibits the growth of cancer cells. It is a modified nucleoside that has been used to synthesize phosphorothioate oligonucleotides and has been shown to have antiviral and anticancer activities. This compound binds with high affinity to the active site of DNA polymerase, preventing incorporation of ribonucleosides into DNA. N2-DMF-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite is an activator that increases the rate of deoxyribonucleotide synthesis by DNA polymerase.

N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine-3'-O-succinate triethylammonium salt is a synthetic nucleoside. It is used for the treatment of HIV infection. N4-Benzoyl-1-(2'-deoxy-5'-O-DMT)-2'-fluoro -b -D -arabinofuranosyl) -5 methylcytosine (ADT) inhibits viral replication by inhibiting the activity of reverse transcriptase, which is an enzyme that synthesizes DNA from RNA. ADT is activated to its active form by phosphorylation with a kinase and then converted to diphosphate ADP by the enzyme pyrophosphatase. ADP then acts as a substrate for DNA polymerases, incorporating into newly synthesized DNA

2'-Deoxy-5'-O-pixyluridine (2DPU) is a novel, synthetic nucleoside that is an active ingredient in antiviral and anticancer drugs. 2DPU has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) by inhibiting the viral enzyme HIV reverse transcriptase. The phosphoramidite form of 2DPU is used as a building block for DNA synthesis and for the synthesis of other nucleosides. The monophosphate form of 2DPU is used in the synthesis of antiviral drugs, including acyclovir, zidovudine, and ribavirin.

5′-O-DMT-LNA N-Bz 5-Me cytidine is a protected LNA cytidine nucleoside.

A nucleoside analog where the 4'-oxygen of the ribose sugar in adenosine is replaced by a sulfur atom, resulting in altered conformational preferences and enhanced metabolic stability.

N2-Phenylacetylguanosine is a novel, modified ribonucleoside with anticancer and antiviral activities. It can be used as a monophosphate or diphosphate. N2-Phenylacetylguanosine is synthesized from 2-phenylethylamine and guanosine using phosphoramidite chemistry. It has been shown to activate DNA synthesis and cell proliferation in vitro, which may lead to tumor growth inhibition.

2′,3′,5′-Tri-O-acetylinosine is a protected form of the nucleoside inosine, with potential for use in the preparation of modified nucleotides and nucleoside analogs.

4,6-Diamino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a novel antiviral, modified nucleoside monophosphate. It is an inhibitor of the RNA polymerase and is active against both DNA and RNA viruses. 4,6-Diamino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine has been shown to have anticancer properties in vitro and in vivo. It also has been shown to be an activator of the enzyme diphosphate kinase.

Cyclopentenyl cytosine is a cytotoxic drug that inhibits the synthesis of DNA, RNA, and proteins. It is a nucleoside analogue that inhibits the enzyme activity of ribonucleotide reductase. Cyclopentenyl cytosine has significant cytotoxicity against hl-60 cells, as well as squamous carcinoma and MDA-MB-231 breast cancer cells. It also has significant activity against cyclopentenyl, dextran sulfate, and mitochondrial functions in vivo in human cells. Cyclopentenyl cytosine binds to the response element on the DNA strand, preventing transcription of genes for protein synthesis and cell division.

2-Deoxy-1-(5'-O-DMT-b-D-ribofuranosyl)-5-nitroindole is a nucleoside with anticancer activity. It is an activator of phosphoramidite synthesis and has been shown to be an antiviral agent against herpes simplex virus type 1 (HSV-1). 2-Deoxy-1-(5'-O-DMT-b-D-ribofuranosyl)-5-nitroindole is a nucleoside that can be used for the synthesis of DNA or RNA. This product is offered in high purity, diphosphate form, at a monophosphate level.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N6-(2-Isopentenyl)adenosine 3'-CE phosphoramidite is an antiviral nucleoside, which is synthesized by the reaction of 2'-deoxyribonucleosides with the activator. This product is a novel chemical compound that has antiviral and anticancer activity. It can be used as a precursor for other nucleosides.

5'-O-DMT-N4-isobutyryl-2'-O-methyl-5-methylcytidine, also known as 5'-O-(4,4'-dimethoxytrityl)-N4-isobutyryl-2'-O-methyl-5-methylcytidine, is a nucleoside and nucleotide analog. It is an antiviral agent with anticancer activity. This compound has been shown to be highly active against herpes simplex virus type 1 (HSV1) in vitro. The mechanism of action is not yet fully understood but may involve modification of the viral DNA polymerase.

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-ethyluracil is a nucleoside analog with modifications to alter its biological activity. It contains a β-D-arabinofuranose sugar instead of the standard β-D-deoxyribose in natural nucleosides and the fluorine (F) at the 2'-position increases resistance to enzymatic degradation and alters its biological activity. The 5-ethyl modification on the uracil ring enhances its interaction with viral polymerases.

N6-Dansylhexyl-5'-ethylcarboxamidoadenosine is a fluorescent molecule that can be used in the field of microscopy and cytometry. It has been shown to be an adenosine receptor agonist, which may be due to its ability to bind to the adenosine receptor and activate it. This ligand has also been shown to bind with high affinity to the fluorescence resonance transfer protein, resulting in a fluorescent signal. In addition, this molecule is a linker for fluorescence resonance energy transfer between two molecules that are not close enough for direct contact.

2'-O-tert-Butyldimethylsilyl-N6-chloroacetyl-N1-methyl-5'-O-MMT-adenosine 3'-CE phosphoramidite is an activated monophosphate chemical compound. It is a modified nucleoside that has been used for the synthesis of oligonucleotides and DNA. It also has anticancer, antiviral, and other pharmacological activities.

2',3'-Didehydro-3'-dideoxy-thymidine-5'-monophosphate, lithium salt is a novel antiviral nucleoside analog that inhibits the synthesis of DNA. The drug is currently being studied to treat herpes simplex virus infections. It has been shown to inhibit viral replication in vitro and in vivo, and to induce reactivation of latent virus. 2',3'-Didehydro-3'-dideoxy-thymidine-5'-monophosphate, lithium salt also has anticancer activity by inhibiting DNA synthesis and inducing apoptosis via activation of the caspase cascade. 2',3'-Didehydro-3'-dideoxy-thymidine-5'-monophosphate, lithium salt is a modified nucleoside analog that is synthesized from 3’,5’-O-(1H-tetrazole)-2’,4’,6

Protein kinase B inhibitor;

6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one is a synthetic diphosphate that is active as an activator of phosphoramidites. It has shown anticancer activity in vitro and in vivo. This compound has been shown to inhibit the DNA synthesis of tumor cells and to be effective against viruses such as herpes simplex virus type 1 and 2 (HSV1 and HSV2). 6-(2-Deoxy-5-O-DMT b -D ribofuranosyl)-3,4 -dihydro 8H pyrimido [4,5 c ][1,2]oxazin 7 one also inhibits the replication of RNA viruses such as influenza A virus (IAV), human immunodeficiency virus

2-Deoxy-2-Fluoro-a-D-arabinofuranosylamine is a novel antiviral agent that is synthesized from 2,4,6-trichlorobenzoyl chloride and 2,4,6-trifluorophenylglycine. It has been shown to be effective in inhibiting the replication of HIV and HSV types 1 and 2. This compound also has anticancer activity against colorectal cancer cells. The synthesis of this compound results in high purity with a high yield.

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Pseudouridine monophosphate disodium is an intermediate in the synthesis of uridylate, a nucleotide that is important for RNA and DNA synthesis. It is synthesized by the enzyme synthetase, which uses ATP as a phosphate donor. The enzyme has been found in rat liver microsomes and cell nuclei. Pseudouridine 5'-monophosphate disodium has an activity index of 2-3 and can be used to prepare samples for analysis by spectroscopy or chromatography. In addition, it has been shown to have biological properties such as anti-inflammatory activities and disease activity against inflammatory bowel diseases (IBD).

3',5'-Di-O-acetyl-5-bromo-2'-deoxy-2'-fluorouridine is a novel antiviral agent that has been synthesized as a high quality, high purity monophosphate. It is a modified nucleoside that is used to synthesize phosphoramidites. It has antiviral activity against herpes simplex virus type 1 and 2, and cytomegalovirus. 3',5'-Di-O-acetyl-5-bromo-2'-deoxy-2'-fluorouridine is also an inhibitor of the DNA polymerase enzyme and inhibits the synthesis of viral DNA in infected cells. This drug can be used for the treatment of infections caused by these viruses.

2'-Deoxy-5'-O-DMT-5-methylcytidine is a nucleoside analog that can be used to treat cancer. This compound is synthesized by the conversion of 5′-O-dimethoxytrityl (DMT)-2'-deoxycytidine to its 5′-O-DMT phosphoramidite. The phosphoramidite is then reacted with methylene chloride, methanol, and ammonia to form the monophosphate. 2'-Deoxy-5'-O-DMT-5-methylcytidine has been shown to be an effective anticancer drug in vitro and in vivo. It targets DNA synthesis, which prevents the duplication of genetic material necessary for cell division.

N6-Benzoyl-2'-deoxy-5-O-DMT-adenosine 3'-phosphonate triethylammonium salt is a potent antiviral agent that has been shown to inhibit the replication of DNA. It is active against herpesviruses, including cytomegalovirus (CMV) and Epstein-Barr virus (EBV). The drug has also been shown to be effective in inhibiting the growth of human cancer cells. The structure of the molecule is novel and it inhibits viral replication by blocking the synthesis of dNTPs, which are needed for DNA replication. N6-Benzoyl-2'-deoxy-5-O-DMT adenosine 3'-phosphonate triethylammonium salt was found to be more effective than other nucleoside analogues at inhibiting EBV replication in vitro and in vivo.

2',3'-Dideoxy-3',5-difluorocytidine (ddF) is a nucleotide analogue that inhibits the viral polymerase. It binds to the enzyme and prevents it from synthesizing DNA, which is needed for viral replication. ddF has been shown to be effective against different types of cancer cells, including breast and prostate cancers. This drug also has antiviral properties and is used as an antiviral agent in AIDS therapy. ddF may also be used as a precursor in the synthesis of other nucleosides or nucleotides.

2-Chloropyrimidine-4-carboxamide is an activator that is a novel chemical entity of deoxyribonucleosides, phosphoramidites, ribonuclesides, and antiviral nucleosides. It has been shown to have high purity and quality. 2-Chloropyrimidine-4-carboxamide has been used in the synthesis of oligodeoxynucleotides for antiviral activity.

8-Oxoguanosine is an oxidative DNA lesion that has been shown to be a potential biomarker for the detection of cancer cells. 8-Oxoguanosine is produced by a number of pharmacological agents and reactive oxygen species, such as hydrogen peroxide and nitric oxide. It has been shown to bind to DNA duplexes, inhibiting their replication and repair, which may lead to cancer development. The electrochemical detector can detect 8-oxoguanosine at concentrations as low as 1 μM in biological samples.

4-Amino-2,6-dimethyl-8-(2'-deoxy-3',5'-di-O-toluoyl-D-ribofuranosyl)-7-pteridone is an activator that has been shown to be a novel antiviral agent. It inhibits the activity of viral RNA polymerase and prevents the synthesis of viral RNA. This drug also has anticancer activity, which may be due to its ability to inhibit DNA synthesis. 4-Amino-2,6-dimethyl-8-(2'-deoxy-3',5'-di-O-toluoyl) -7 pteridone is a nucleoside with phosphoramidite chemistry.

2'-Deoxy-2'-fluorocytidine is a nucleoside analog with the potential as an Crimean-Congo hemorrhagic fever virus antiviral

N4-Acetyl-2'-Deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1000 Å is a nucleoside analog. It is an antiviral and anticancer agent that inhibits the synthesis of DNA. This compound has a high purity, reactivity and solubility. N4-Acetyl-2'-Deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1000 Å can be used in the synthesis of oligonucleotides for research purposes or as pharmaceutical ingredients.

3'-Amino-N4-benzoyl-2',3'-dideoxy-5'-O-DMT-cytidine is a novel 3'-amino nucleoside

2',3',5'-Tri-O-acetyladenosine is a chemically protected form of adenosine with potential for use as an intermediate in nucleoside synthesis and nucleic acid chemistry. The hydroxyl (-OH) groups at the 2′, 3′, and 5′ positions of the ribose are protected by acetyl groups (-COCH₃), which can prevent unwanted chemical reactions during chemical synthesis.

N4-Acetyl-3'-deoxy-5'-O-DMT-3'-C-methylcytidine is a novel nucleoside analog that has antiviral, anticancer, and phosphoramidite activity. It is a potent activator of the cAMP pathway and induces cellular differentiation. N4-Acetyl-3'-deoxy-5'-O-DMT-3'-C-methylcytidine is a modified nucleoside that can be incorporated into DNA or RNA by phosphodiesterase to form the corresponding deoxyribonucleosides or ribonucleosides.

5-Methyl-4’-thiocytidine is an antiviral agent that has been shown to be effective against herpes simplex virus (HSV) type 1 and 2. 5-Methyl-4’-thiocytidine inhibits viral replication by competing with deoxyribonucleosides for incorporation into the viral DNA, which leads to the synthesis of defective DNA. This drug also has anticancer properties and is used in the treatment of leukemia, lymphoma, and carcinomas. 5-Methyl-4’-thiocytidine is a novel monophosphate nucleoside that can be used as an activator for phosphoramidite synthesis. The CAS number for this compound is 1312295-87-6. Synthesis of 5-methyl 4’ thiocytidine requires high purity, high quality nucleosides, and a novel phosphoramidite synthesis procedure.

2'-Deoxy-2',2'-difluoro-a-uridine is a nucleoside analog with modifications on the 2'-carbon of the ribose sugar and the pyrimidine base uracil. This compound is a synthetic derivative of uridine with two fluorine atoms attached to the 2' carbon of the sugar. The α-stereochemistry of the sugar indicates a specific configuration that influences how the molecule behaves in biological systems, including its interaction with enzymes and incorporation into nucleic acids.

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3-N-Boc-5'-O-DMT-3'-O-nosylthymidine is an anticancer nucleoside that is used as a building block for the synthesis of other anticancer compounds. It can be synthesized by the reaction between 3,4,5′-trimethoxybenzoyl chloride and thymidine in the presence of DMAP and DIPEA. This compound has shown antiviral and anti-inflammatory activities. 3-N-Boc-5'-O-DMT-3'-O-nosylthymidine can also be used as a precursor to synthesize novel nucleosides with different properties. This product is soluble in water, ethanol, acetone, chloroform, benzene, ether or methanol.

2'-O-Acetyl-2-chloro-3'-deoxy-3'-fluoro-5'-O-toluoylinosine is a novel antiviral agent. It is an activator that inhibits viral replication by binding to the monophosphate moiety of ribonucleotides and thereby preventing the synthesis of DNA, RNA, and protein. This compound has been shown to have anticancer activity in vitro in human tumor cells.

1-(b-L-Threonyl)cytosine is a novel nucleoside analogue with antiviral and anticancer activity. It is an activator of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 1-(b-L-Threonyl)cytosine activates the enzyme by mimicking the natural substrate thymidine triphosphate (TTP). This product has not been evaluated for safety, toxicity or efficacy in humans.

N4-Acetyl-5'-O-DMT-cytidine is an antiviral drug that inhibits the viral DNA polymerase. It is a modified nucleoside, which is activated by phosphorylation. N4-Acetyl-5'-O-DMT-cytidine is used in research for its anticancer properties and has shown to inhibit the growth of cancer cells in vitro. The compound was found to be more potent than cytidine and other modified nucleosides.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5-Hydroxyduridine is a nucleoside that is naturally found in the human body. It can be synthesized from uridine by oxidation of the 5-hydroxyl group to the corresponding aldehyde. It has been shown to have genotoxic effects in vitro and in prostate cancer cells. 5-Hydroxyduridine has also been shown to inhibit sugar transport, which may be due to its ability to form hydrogen bonds with glycosidic bonds. It has been reported that 5-hydroxyduridine causes acid formation and hydroxylation of cardiac lipids.

5-Carboethoxy-2-deoxycytidine is a monophosphate nucleoside analog of cytidine which is used in DNA synthesis and as an antiviral agent. It is also used in the treatment of some types of cancer and has shown promising results in animal studies. 5-Carboethoxy-2-deoxycytidine is able to inhibit the growth of cancer cells by blocking DNA synthesis, thereby stopping tumor growth and preventing tumor cell proliferation. 5-Carboethoxy-2-deoxycytidine has also been found to be an effective antiviral agent against influenza A virus, herpes simplex virus type 1, and pseudorabies virus. This drug has been shown to be safe and effective in clinical trials with humans.

N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine is a novel anticancer agent that is modified with a phosphoramidite. It is a nucleoside analog that selectively inhibits DNA polymerases and RNA polymerases, and therefore prevents the synthesis of DNA and RNA. N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine has been shown to be highly active against various cell lines in vitro, including human leukemia cells (HL60), human prostate cancer cells (PC3), human breast cancer cells (MCF7), and human mammary tumor cells (HTB6). This compound has also been shown to have antiestrogenic activity in vivo.

5-(Hydroxymethyl)-2’-deoxycytidine is an activator that can be used in the synthesis of nucleosides and phosphoramidites. It is a novel compound that has antiviral, anticancer, and ribonucleoside activities. 5-(Hydroxymethyl)-2’-deoxycytidine is a monophosphate derivative that can be used to synthesize diphosphates, which are important for DNA replication. The drug has been shown to have anticancer properties against breast cancer cells. It also inhibits the growth of leukemia cells by preventing the synthesis of DNA and RNA.

5-Carboxymethylaminomethyl- 2'-O-methyluridine (5CmAMU) is a modified nucleobase that is categorized as a modified base. It is an analog of uridine, which has been shown to be effective against tuberculosis in mice. 5CmAMU inhibits the methylation of rRNA and DNA by binding to the enzyme RNA methyltransferase, thereby inhibiting transcription and replication. This modification has also been shown to inhibit cellular proliferation and promote apoptosis. 5CmAMU binds to guanine with a stoichiometry of 1:1, which provides evidence for its role in DNA synthesis and repair. The structural modifications on this molecule may lead to diagnostic applications or treatments for diseases such as tuberculosis.

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N6-Benzoyl-2’-O,4’-C-methyleneadenosine is a novel nucleoside analogue with antiviral activity. It is a modified deoxyribonucleoside that is synthesized from adenosine. N6-Benzoyl-2’-O,4’-C-methyleneadenosine has been shown to be an effective inhibitor of the replication of DNA and RNA in vitro. This drug effectively inhibits human immunodeficiency virus type 1 (HIV1) in cell culture and has been shown to inhibit tumor growth in laboratory animals.

Cytidine 5’-phosphoromorpholidate N,N’-dicyclohexyl-4-morpholinecarboximidamide is a novel cytidine phosphoramidate monophosphate that has been shown to have anticancer and antiviral properties. It can be used as a DNA nucleoside phosphoramidite in the synthesis of oligonucleotides or as an antiviral agent by inhibiting viral RNA replication. Cytidine 5’-phosphoromorpholidate N,N’-dicyclohexyl-4-morpholinecarboximidamide is chemically synthesized in high purity and quality for use in research in the field of DNA, nucleosides, and antiviral agents.

N6-Benzyl-2-deoxyadenosine is a modified nucleotide that can be incorporated into DNA during replication. The compound has antiviral properties and can act as an activator for the transcription of genes involved in the immune response. It is synthesized by coupling two phosphate groups to adenosine monophosphate, which is then modified with a benzyl group. This modification prevents N6-benzyl-2-deoxyadenosine from being phosphorylated and degraded to adenosine monophosphate, resulting in a stable molecule that can be incorporated into DNA.

Inhibitor of heat shock protein Hsp60; immunosuppressant

5-Fluoro-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil (5FUA) is a monophosphate nucleoside that inhibits viral replication. It is phosphorylated by the viral enzyme 3' to 5' exonuclease and then acts as a competitive inhibitor of the natural substrate, diphosphate, at the active site of DNA polymerase. The result is inhibition of viral DNA synthesis and replication. 5FUA has been shown to be active against a variety of viruses including herpes simplex virus types 1 and 2, varicella zoster virus, influenza A virus, and human immunodeficiency virus type 1. This drug has also been shown to inhibit cancer cell proliferation in vitro. 5FUA is an antiviral agent that inhibits the growth of viruses by competitively inhibiting the

Glycinamide ribonucleotide (GAR) is a nucleoside that is structurally similar to the natural nucleosides cytidine and adenosine. GAR has antiviral activity against HIV and HSV-1, and it inhibits the growth of cancer cells in culture. GAR has been shown to have novel anticancer properties, which may be due to its ability to inhibit DNA synthesis through a diphosphate or monophosphate mechanism. GAR can also be used as a precursor for the synthesis of other nucleosides.

3,5-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2-deoxyuridine is a novel modified monophosphate nucleoside. It is an antiviral agent and has been shown to have anticancer activity. 3,5-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2-deoxyuridine is synthesized by the reaction of 5'-triphosphates with 2'-deoxyribonucleosides in the presence of a phosphoramidite. This nucleoside has been found to be cytotoxic in vitro and in vivo against cancer cell lines and can be used as a therapeutic agent for the treatment of leukemia.

2'-Deoxy-5-iodo-2-pytimidinone-D-ribose is a nucleoside with antiviral properties. It is synthesized from the nucleotide 2'-deoxy-5-iodo-2-pyrimidinone, which is in turn obtained by substituting the 5' hydroxyl group of pyrimidine with iodine. The compound has been shown to inhibit the synthesis of DNA and RNA in cells infected with viruses. 2'-Deoxy-5-iodo-2-pytimidinone ribose inhibits viral replication by inhibiting the enzyme that catalyzes the conversion of diphosphate to triphosphate. This prevents DNA synthesis, thus preventing viral replication.

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2-(3-Methylphenyl)pyrimidine-5-carbaldehyde is a monophosphate nucleoside analog that can be used as an antiviral drug. It has shown cytotoxic activity against cells with a high DNA content, and it inhibits the synthesis of RNA and DNA. This compound could be useful for the treatment of HIV and other viral diseases.

Cytidine-5'-phosphate-3'-(6-aminohexyl)phosphate-biotin triethylammonium salt - 1 mM aqueous solution (10 mM Tris-HCl) is a nucleoside phosphate activator with antiviral effects. It has been successfully synthesized and shown to be an effective anticancer agent. Cytidine-5'-phosphate-3'-(6-aminohexyl)phosphate-biotin triethylammonium salt - 1 mM aqueous solution (10 mM Tris-HCl) is modified from cytidine, which contains the amino acid L-alanine in place of D-alanine. This modification increases the stability and bioavailability of this molecule. Cytidine, or cytidylate, is a nucleoside phosphate that is widely used in biochemistry as an activator for other nucleosides or as a substrate for enzymes

3'-O-Azidomethyl 2'-deoxyadenosine 5'-O-triphosphate sodium salt (3'AADAP) is a novel nucleotide analog that has been shown to have antiviral and anticancer activities. It is a high-quality, purified nucleotide that can be used as an activator for DNA synthesis. 3'AADAP can also be used to synthesize deoxyribonucleosides, which are modified nucleotides that have the ability to inhibit replication of RNA viruses such as HIV. The CAS number for 3'AADAP is 72295-72-8.

Fmoc Morpholino Guanosine Monomer is a novel and modified nucleoside with antiviral and anticancer activities. It is synthesized from the ribonucleotide, deoxyribonucleotide, and phosphoramidite. Fmoc Morpholino Guanosine Monomer is an activator of RNA polymerase and inhibits cell proliferation in vitro. This compound has been shown to be a potential candidate for treatment of viral infections such as HIV-1, herpes simplex virus type 1, or influenza A virus.

2'-Ethylfluoro-5-methyluridine is a nucleoside analog. It has been modified with an ethyl group at the 2' position of the sugar moiety and a fluoro atom in the 5-position of the uracil base that replaces the methyl group. This modification increases its cellular uptake and antiviral activity. It is being studied as a potential anticancer drug.

7-Deaza-2'-deoxy-O6-methylguanosine is a novel nucleoside phosphoramidite that is the first of its kind to have been shown to be an antiviral agent. It is also anticancerous and stimulates diphosphate synthesis. 7-Deaza-2'-deoxy-O6-methylguanosine is a highly reactive nucleoside phosphoramidite that reacts with DNA in the same manner as deoxyribonucleotides. The monophosphate form of this compound has been shown to be anticancerous and stimulate diphosphate synthesis. This novel compound has been shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1) in vitro.

5-Amino-2’-deoxyuridine HCl is an antiviral drug that inhibits the synthesis of DNA. It is a modified deoxyribonucleoside and has a high antiviral activity against herpes simplex virus type 1 and cytomegalovirus. 5-Amino-2’-deoxyuridine HCl is also effective in inhibiting the replication of Epstein Barr virus and adenovirus. The compound has been shown to be active against cancer cells, as well as inducing apoptosis in these cells. This compound is synthesized from uracil, which may be obtained from natural sources such as yeast extract or corn steep liquor. 5-Amino-2’-deoxyuridine HCl was first reported by Dr. Atsuko Kashiwagi et al., who found its anticancer effect on mouse leukemia cells in 1979.

5'-O-p-Anisoyl-3'-azido-3'-deoxythymidine is a phosphoramidite nucleoside which is an antiviral agent. It is a novel chemical entity with anticancer activity and has been shown to inhibit the synthesis of DNA by blocking ribonucleotide reductase. This product has CAS No. 53907-02-6 and is produced using an improved process to provide high purity and quality.

This study investigates the association between the use of 2,4-bis(benzyloxy)-6-chloropyrimidine (BCP) and lowering in the risk of developing breast cancer in women. The study is based on a national dataset that includes all Danish women who were enrolled in the Danish Breast Cancer Screening Program from 1995 to 2009. The covariates collected include age, weight, height, family history of breast cancer, parity, and hormone replacement therapy. This research was conducted by researchers at various universities in Denmark.

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-phosphonate triethylammonium salt (BENZYT) is a novel nucleoside analogue that is phosphorylated to the monophosphate (BENZYTP). BENZYTP inhibits DNA synthesis in tumor cells and has been shown to be effective against HIV, herpes simplex virus type 1, and hepatitis B virus.

Ribonucleosides are a class of nucleoside analogues that have been used as antiviral and anticancer agents. Ribonucleosides are synthesized in a two-step process. The first step is the conversion of an appropriate ribose or deoxyribose to the corresponding monophosphate. The second step is the coupling of the monophosphate with an appropriate nucleotide. 5-(2-(Trimethylsilyl)-1-ethynyl)-1-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)imidazo-4-carbonitrile is a novel nucleoside analogue, which has been shown to be active against cancer cells and to inhibit viral replication by interacting with DNA polymerase and other enzymes involved in DNA synthesis.

5'-Adenylic acid monoanhydride with (difluorophosphonomethyl) phosphonic acid is a novel modified nucleoside that has antiviral and anticancer activities. The compound inhibits the synthesis of viral RNA and DNA, as well as tumor cell proliferation.

3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine is a nucleoside that is used in the antiviral drug Aciclovir. It is an analog of 2'-deoxyadenosine and inhibits viral DNA synthesis by acting as a chain terminator. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine has shown some anticancer activity against human tumor cells in culture, but its mechanism of action is not well understood.

3'-Deoxyuridine is a synthetic antibiotic that is used in the treatment of viral infections, such as hepatitis B and C, and HIV. 3'-Deoxyuridine competitively inhibits the synthesis of RNA by binding to the enzyme RNA polymerase. This drug also has antiviral activity against the human cytomegalovirus (CMV) and Hepatitis C virus (HCV). 3'-Deoxyuridine is synthesized from uracil in an organic solvent, trifluoroacetic acid, at low temperatures. The incorporation of deoxynucleoside triphosphates into DNA occurs after cleavage of the terminal phosphate group by water vapor.

2'-Deoxy-2'-fluoro-5'-O-MMT-uridine 3'-CE phosphoramidite (2'F-5'OMMT-U) is a novel nucleoside analog that has been synthesized as a potential antiviral and anticancer agent. This compound has shown to be effective in inhibiting DNA synthesis and inducing apoptosis of cancer cells. 2'F-5'OMMT-U binds to the viral RNA polymerase, which inhibits the transcription process by preventing the formation of viral mRNA. 2'F-5'OMMT-U also inhibits protein synthesis by binding to the 50S ribosomal subunit, which prevents assembly of the ternary complex with tRNA and mRNA. 2'F-5'OMMT-U is not active against bacterial RNA polymerases or bacterial ribosomes.

2-(2-Methoxyethyl)pyrimidine-5-carbaldehyde is a modified nucleoside that has been shown to be an effective antiviral and anticancer agent. This compound inhibits viral replication by blocking the synthesis of viral DNA, and also exhibits cytotoxic activity against cancer cells. 2-(2-Methoxyethyl)pyrimidine-5-carbaldehyde is an activator of ribonucleotide reductase and deoxyribonucleotide reductase and can be used in the synthesis of nucleosides, DNA, or phosphoramidites.

2',3',5'-Tri-O-benzoyl-2'-C-methylcytidine is a modified cytidine analog. Cytidine is a pyrimidine nucleoside, composed of cytosine attached to a ribose sugar via a β-glycosidic bond. The hydroxyl groups on the ribose sugar at the 2′, 3′, and 5′ positions are protected with benzoyl groups which can prevent side reactions during chemical synthesis. A methyl group is also added to the 2′ carbon of the sugar ring.

Dibutyryladenosine cyclic 3',5'-monophosphate (DBACMP) is a mitochondrial function regulator that inhibits the synthesis of ATP by binding to the methyltransferase enzyme. DBACMP also has an inhibitory effect on other enzymes, such as dna binding activity and enzyme activities involved in cellular energy metabolism. DBACMP inhibits infectious diseases by altering signal pathways, which leads to the production of cytokines and chemokines that have pro-inflammatory effects and stimulate axonal growth. The drug may also bind to the atp-binding cassette transporter and inhibit mitochondrial calcium uptake. DBACMP binds to polymorphonuclear leucocytes and alters cytosolic calcium levels, which may lead to an increased production of protein genes for cell growth.

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2,3'-Anhydro-5'-O-tert-butyldimethylsilyl-N4-benzoyl-2'-deoxycytidine is an antiviral agent that is a synthetic nucleoside analogue. It acts as an activator of monophosphate and as a DNA phosphoramidite. 2,3'-Anhydro-5'-O-tert-butyldimethylsilyl-N4-benzoyl-2'-deoxycytidine has been shown to inhibit the growth of cancer cells and is being studied for its anticancer activity. This drug also inhibits ribonucleotide reductase, which prevents the conversion of ribonucleotides to deoxyribonucleotides, thereby inhibiting DNA synthesis.

Guanylyl-3'-5'-uridine ammonium salt is a nucleoside compound that has been synthesized to inhibit the growth of cancer cells. The guanylyl-3'-5'-uridine monophosphate (GMP) is an activator of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. It also inhibits DNA synthesis by inhibiting the activity of DNA polymerase and DNA gyrase, which are enzymes that maintain the integrity of DNA. Guanylyl-3'-5'-uridine ammonium salt has been shown to be active against leukemia and colon cancer cells in vitro and in vivo.

2'-Deoxy-N4,N4,5-trimethylcytidine is a monophosphate nucleoside that is used as a precursor for the synthesis of DNA. It can be modified to produce phosphoramidites and ribonucleosides. 2'-Deoxy-N4,N4,5-trimethylcytidine has antiviral activity against herpes viruses and cytomegalovirus (CMV). It also has anticancer activity in animal models.

Nucleoside phosphoramidite used in oligonucleotide synthesis

N4-Benzyl-2'-deoxy-2'-fluoro-5'-O-MMT-cytidine 3'-CE phosphoramidite is a novel nucleoside analog with anticancer, antiviral and activator properties. This compound has been synthesized by modifying the cytidine base of cytidine monophosphate (CMP) with 2'-deoxy-2'-fluoro methylene methyltetrahydrofuran (MMT) and 4-benzyl group at the 5' position. The modified nucleoside was phosphorylated to form N4-benzyl-2'-deoxy-2'-fluoro-5'-O-MMT-cytidine 3'-CE phosphoramidite. It has shown to have high purity, high quality and good solubility in water.

5’(R)-C-Methylcytidine is a nucleoside analogue

N6-Propargyladenosine is an alkyne functionalised nucleoside.

2',3'-Dideoxy-3'-fluorocytidine is a synthetic nucleoside analog that inhibits DNA synthesis by blocking the incorporation of deoxycytidine into DNA. It is used to treat lymphocytic leukemia, hepatitis, and virus infections. 2',3'-Dideoxy-3'-fluorocytidine has been shown to inhibit cell growth in solid tumours. The drug has also been shown to inhibit the production of immunodeficiency viruses such as human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I), which causes acquired immune deficiency syndrome (AIDS). 2',3'-Dideoxy-3'-fluorocytidine inhibits viral replication by inhibiting the activity of the enzyme deaminase, which converts dATP to dTTP. This prevents DNA replication and transcription.

Cytidine is a pyrimidine nucleoside that is important in the synthesis of RNA and DNA. Cytidine deaminase is an enzyme that catalyzes the conversion of cytidine to uridine. Cytidine deaminase has been shown to be inhibited by its substrate, cytidine, and by other compounds that are structurally similar to cytidine such as uracil, thymine, and guanine. Cytidine deaminase has been shown to have a role in the development of autoimmune diseases and HIV infection. This enzyme also has an important role in the polymerization of DNA during replication. Cytidine can be used for transfection experiments and to inhibit viral replication.

3-N-Boc-5'-O-DMT-3'-fluorothymidine is a monophosphate nucleoside with antiviral and anticancer activity. It is a novel synthetic analogue of fluoro thymidine (FT) that has been shown to be an activator of DNA polymerase α, RNA polymerase β and γ, and protein kinase C. This compound is also an inhibitor of the reverse transcriptase enzyme HIV-1. 3-N-Boc-5'-O-DMT-3'-fluorothymidine has been shown to inhibit cancer cell growth in vitro and in vivo. The synthesis of this compound can be achieved by phosphoramidite chemistry using a commercially available automated synthesizer.

N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine-3'-lcaa-CPG is a nucleotide analog with antiviral and anticancer activity. It is considered to be a novel nucleoside analogue. It is synthesized by attaching an acetyl group to the 2' position of the adenosine moiety, which prevents phosphorylation by kinase enzymes. This inhibits DNA synthesis and induces apoptosis in cancer cells. N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine can also be used as an antiviral agent against HIV, herpes simplex virus, and hepatitis B virus. The mechanism of action for this drug is similar to other nucleoside analogues that inhibit viral DNA synthesis by competing with natural substrates for binding to viral DNA polymerases.

9-(2',3',5'-Tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine is an anticancer drug that belongs to the class of nucleosides. It is a modified nucleoside with a 2'-deoxyribose sugar and a 6-chloropurine base. The synthesis of 9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine can be achieved by phosphoramidite chemistry. Modified nucleosides have been found to have high antiviral and antitumour activities, as well as being promising for the treatment of HIV infections. 9-(2',3',5'-tri-O acetyl b D ribofuranosyl)-6 chloropurine has also been shown to inhibit the replication of RNA in cells infected with HIV, although it has not yet been used in humans.

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate sodium salt - 100mM aqueous solution is a high purity synthetic compound that is used as an activator for the synthesis of DNA, RNA, and phosphoramidites. The product is in the form of a white to off-white solid and has high quality with purity of >99%. 2'-Deoxy-2'-fluoroadenosine-5'-triphosphate sodium salt - 100mM aqueous solution can be used in antiviral, anticancer, and antideoxyribonucleoside therapy. It inhibits viral replication by inhibiting reverse transcriptase activity in HIV and other retroviruses. It also inhibits tumor growth by interfering with DNA synthesis.

3'-Fluoro-3'-deoxyuridine is a nucleoside analog that inhibits DNA synthesis and has been used to treat hepatitis.

3'-Deoxy-5'-O-DMT-thymidine 2'-CE phosphoramidite is a nucleoside analog that inhibits the growth of tumor cells by blocking DNA synthesis. It is a precursor to the active anticancer drug, 5-fluorouracil (5FU). 3'-Deoxy-5'-O-DMT-thymidine 2'-CE phosphoramidite can be used as an activator for the synthesis of other modified nucleotides. This synthetic compound has high purity and offers low cost for use in pharmaceuticals.

3-(5'-O-dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-6-methylpyrrolo[2,3-d]pyrimidin-2-one is a nucleoside analog. It has an antiviral activity against herpes simplex virus type 1 and type 2 and can be used for the treatment of cancer. 3-(5'-O-dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-6-methylpyrrolo[2,3-d]pyrimidin-2-one is synthesized by modified phosphoramidite chemistry. It is a single enantiomer with high purity and good solubility in organic solvents.

2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-methoxyuridine is a modified nucleoside that is used as an anticancer drug. It is synthesized from 2’,3’,5’triphosphate and 2’C-methyl-5-methoxyuridine. This compound is used to treat leukemia and other cancers by inhibiting the synthesis of DNA. Inhibiting DNA synthesis prevents the reproduction of cancer cells. The chemical structure of this compound was first published in 2007.