Antidepressant

Applications The isotopically labelled Bupropion ((B689625), a selective inhibitor of dopamine uptake. Bupropion is an antidepressant of the aminoketone class; aid in smoking cessation. References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977), Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983), Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997), West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003),

Applications A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant. References Wong, D.T., et al.: Life Sci., 15, 471 (1974), Goldstein, D.J., et al.: Br. J. Psychiat., 166, 660 (1995), Ni, Y.G., et al.: Proc. Nat. Acad. Sci. USA, 94, 2036 (1997)

Impurity Fluoxetine EP Impurity B; Fluoxetine USP Related Compound B Applications N-Methyl-3-phenylpropylamine (Fluoxetine EP Impurity B; Fluoxetine USP Related Compound B) is a Fluoxetine (F597100) impurity. References Kraiczek, S., et al.: Pharmazie, 54, 471 (1999), Krzek, J., et al.: J. Pharm .Biomed. Anal., 21, 451 (1999),

Applications Antidepressant; antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Maxwell, R.A., et al.: J. Pharm. Exper. Therap., 178, 158 (1970), Tait, A.C., et al.: J. Clin Pharmac., 2, 93 (1975), Rossi, G.V., et al.: Am. J. Pharm., 148, 37 (1976), Hubbard, J.W., et al.: J. Pharm. Sci., 67, 1571 (1978),

Applications A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.Also used as high-dose venlafaxine treatment in depressed patient with a genetic CYP2D6 deficiency. References Haller-G., et al.: Int. J. Psychiatry Clin. Pract., 8, 191 (2004)

Applications erythro-Dihydro Bupropion-d9 Hydrochloride is the labeled hydrochloride salt analogue of erythro-Dihydro Bupropion (D448650), a metabolite of the drug Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation. References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003)

Applications Clomipramine-d3 HCl (N-methyl-d3) (CAS# 1398065-86-5) is a useful isotopically labeled research compound.

Applications 3-Chloropropiophenone is an impurity of Fluoxetine (F597100). References Wirth, D.D. et al.: Chromatographia, 46, 511 (1997); Lacroix, P.M. et al.: J. AOAC Int., 78, 334 (1995);

Applications A metabolite of Bupropion, an antidepressant. The compound exists mainly as cyclic acetal (2-hydroxy-2-(3’-chlorophenyl)-355-trimethylmorpholine). See US Pat. # 634.2496 References Hsyu, P-H., et al.: J. Clin. Pharm., 37, 737 (1997), Rotzinger, S., et al.: Cellular & Mol. Neurobiology, 19, 4, 427 (1999); US 6342496

Applications A labelled metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant. References Wong, D., et al.: J. Pharmacol. Exp. Ther., 193, 804 (1975), Thorsen, T., et al.: J. Cancer Clin. Oncol., 18, 333 (1982), Howell, A., et al.: Lancet, 365, 60 (2005),

Stability Hygroscopic Applications Labelled Milnacipran. Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Moret, C., et al.: Neuropharmacology, 24, 1211 (1985), Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989), Spencer, C.M., et al.: Drugs, 56, 405 (1998),

Applications Fluoxetine (F597100) derivative. References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)

Applications rac-erythro-Dihydro Bupropion Hydrochloride is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation. References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)

Applications A labelled metabolite of Mazindol. An imidazolinylphenyl ketone derivatives as antidepressants and diuretics. References Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Murray, S., et al.: Xenobiotica, 31, 135 (2001), Lewis, D., et al.: Drug Metab. Rev., 34, 55 (2002), de Graaf, C., et al.: J. Med. Chem., 48, 2725 (2005),

Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.

Applications threo-Dihydro Bupropion-d9 Hydrochloride is the labeled metabolite of Bupropion Hydrochloride (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation. References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003)