Antidepressant

Applications It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone. References Melzacka, M., et al.: Pol. J. Pharmacol Pharm., 32, 551 (1980), Fong, M.H., et al.: J. Pharm. Pharmacol., 34, 674 (1982), Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995), Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997), Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008),

Stability Hygroscopic Applications A labelled metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant. References Wong, D., et al.: J. Pharmacol. Exp. Ther., 193, 804 (1975), Thorsen, T., et al.: J. Cancer Clin. Oncol., 18, 333 (1982), Howell, A., et al.: Lancet, 365, 60 (2005),

Applications N-Nitroso Fluoxetine is a derivative of Fluoxetine Hydrochloride(F597100) which is a selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wong, D.T., et al.: Life Sci., 15, 471 (1974), Goldstein, D.J., et al.: Br. J. Psychiat., 166, 660 (1995), Ni, Y.G., et al.: Proc. Nat. Acad. Sci. USA, 94, 2036 (1997)

Applications Antipsychotic; antidepressant; antiemetic. References Karolidis, D., et al.: Med. Chem., 6, 259 (2010), Cummings, D., et al.: J. Pharmacol. Exper. Ther., 335, 518 (2010),

Impurity Escitalopram EP Impurity K Stability Hygroscopic Applications (R)-Citalopram Oxalate (Escitalopram EP Impurity K) is an inhibitor of serotonin (5-HT) uptake. Antidepressant. References Christensen, A.V., et al.: Eur. J. Pharmacol., 41, 153 (1977), Keller, M.B., et al.: J. Clin. Psychiatry, 61, 896 (2000), Von Moltke, L.L., et al.: Drug Metab. Dispos., 29, 1102 (2001), Fish, E.W., et al.: J. Pharmacol. Exp. Ther, 308, 474 (2004),

Applications D,L-O-Desmethyl Venlafaxine N-Oxide is metabolite of the drug Venlafaxine (V120000(P)), which is a selective serotonin noradrenaline reuptake inhibitor and used as an antidepressant. References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)

Applications Labelled Fluoxetine (F597100) derivative. A stereoselective inhibitorof serotonin re-uptake and phosphodiesterase. Potential antidepressants References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)

Stability Hygroscopic Applications Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant. References Blaney, W., et al.: Physiol. Entomol., 12, 281 (1987), Sethi, M., et al.: J. Pharm. Sci., 72, 538 (1983), Yahara, S., et al.: Chem. Pharm. Bull., 33, 527 (1985),

Applications A metabolite of Mianserin. References Begg, E., et al.: Br. J. Clin. Pharmacol., 27, 445 (1989), Tybring, G., et al.: Ther. Drug Monit., 17, 516 (1995), Namera, A., et al.: J. Anal. Toxicol. 22, 396 (1998), van Nederkassel, A., et al.: J. Pharm. Biomed. Anal., 32, 233 (2003),

Applications A selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant. References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)

Applications A labelled metabolite of Amoxapine. References Hansen, E., et al.: Drug Metab. Dispos.,15, 97 (1987), Hansen, E., et al.: Xenobiotica, 25, 1081 (1995), Moody, J., et al.: Drug Metab. Dispos., 27, 1157 (1999),

Applications Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant. References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),

Applications Antidepressant; antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Maxwell, R.A., et al.: J. Pharm. Exper. Therap., 178, 158 (1970), Tait, A.C., et al.: J. Clin Pharmac., 2, 93 (1975), Rossi, G.V., et al.: Am. J. Pharm., 148, 37 (1976), Hubbard, J.W., et al.: J. Pharm. Sci., 67, 1571 (1978),

Stability Hygroscopic Applications rac threo-Dihydro Bupropion Hydrochloride a metabolite of the drug Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation. References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003)

Applications A metabolite of Amoxapine. References Hansen, E., et al.: Drug Metab. Dispos.,15, 97 (1987), Hansen, E., et al.: Xenobiotica, 25, 1081 (1995), Moody, J., et al.: Drug Metab. Dispos., 27, 1157 (1999),

Applications Fluoxetine (F597100) derivative. A stereoselective inhibitorof serotonin re-uptake and phosphodiesterase. Potential antidepressants References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)

Applications Dibenzepin (D416920) derivative. Pharmaceutically active compound.

Applications The R-(+) enantiomer of Mecamylamine (M202600), a noncompetitive neuronal nicotinic receptor modulator antagonist with antidepressant activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fryer, J., et al.: J. Pharmacol. Exp. Ther., 288, 88 (1999), Slemmer, J., et al.: J. Pharmacol. Exp. Ther., 295, 321 (2000), Young, J., et al.: Clin. Ther., 23, 532 (2001),