Atypical Antipsychotics

Applications The labelled cis(Z)-form of Clopenthixol. Thioxanthene neuroleptic. Antipsychotic. References Sabbe, B., et al.: J. Psychiatr. Res., 30, 295 (1996), Riley, E., et al.: Schizophr. Res., 43, 47 (2000), Green, M., et al.: Biol. Psychiatry., 51, 972 (2002), Morrens, M., et al.: J. Clin. Psychopharmacol., 27, 15 (2007),

Applications An antipsychotic used for treatment of schizophrenia. References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),

Loxapine, a dibenzoxazepine antipsychotic, treats schizophrenia by blocking D2/D4 and serotonin receptors. Related to clozapine.

Applications Drug used in the treatment of Parkinson’s disease and psychosis. References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010),

Stability Air Sensitive Applications 3-Hydroxypromazine is a metabolite of Promazine (P756300); an antipsychotic and tranquilizer. References Banci, L., et al.: Biochemistry, 38, 3205 (1999); Lawal, O., et al.: Food Chemi., 87, 205 (2004); Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007)

Stability Hygroscopic Applications A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic. References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Tanaka, E., et al.: J. Clin. Pharm. Ther., 24, 7 (1999)

Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),

Stability Toxic Applications Zotepine-d6, is the labeled analogue of Zotepine (Z700900), an atypical antipsychotic drug used for the treatment of acute and chronic schizophrenia, and acute bipolar mania. It acts as antagonist at dopamine and serotonin receptors. It has a high affinity for the D1 and D2 receptors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chan, H, et al.: Psychiat. Clinical Neurosciences 64 (2), 162 (2010); Harada, T., et al.; Clinical Therapeutics 8 (4), 406 (1986);