Atypical Antipsychotics

Applications A deuterated analog of Paliperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),

Applications Clozapine-d4 can act as modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gant, T. G., U.S. Pat. Appl. Publ. (2010), US 20100166887 A1, 20100701

Applications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation. References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

Stability Hygroscopic Applications Antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, E.L., et al.: Arzneim.-Forsch., 12, 937 (1962), Dreyfuss, J., et al.: J. Pharm. Sci., 60, 826 (1971), Florey, K., et al.: Anal. Profiles Drug Subs., 2, 245 (1973).

Stability Hygroscopic, Light Sensitive Applications Loxapine N-Oxide is a metabolite of Loxapine (L472750), a D2/D4-Dopamine receptor antagonist. It is a serotonergic receptor antagonist that acts as a dibenzoxazepine antipsychotic agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)

Applications 4-Chloro Perphenazine is an impurity of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. References Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),

Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.

Applications Antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Janssen, et al.: J. Med. Pharm. Chem., 1, 281 (1959), Fishburn, C., et al.: J. Biol. Chem., 274, 18793 (1999), Burris, K., et al.: J. Pharmacol. Exp. Ther., 302, 381 (2002), Akam, E., et al.: Biochem. Pharmacol., 67, 2039 (2004), Harrison, T., et al.: Drugs, 64, 1715 (2004),