Valproic Acid and Impurities

Stability Hygroscopic, Light and Temperature Sensitive Applications A metabolite of Valproic Acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

2-Demethoxy-4-methoxy urapidil is a drug product that is used in the development of new drugs. It is a synthetic compound that is metabolized to form its natural metabolite, 2-demethoxyurapidil. This impurity standard has been shown to have anti-inflammatory effects and can be used as an API impurity for pharmacopoeia. 2DMO4MU has been shown to be useful in the study of metabolism and has been found to inhibit prostaglandin synthesis.

Applications An impurity found in valproic acid (V094750, S674500). References Haj-Yehia, A., et al.: Pharm. Res., 6, 683 (1989), Davis, R., et al.: Drugs, 47, 332 (1994), Haj-Yehia, A., et al.: J. Pharm. Sci., 79, 719 (1990),

Applications A metabolite of Valproic Acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

2-Demethoxy-2-chloro urapidil is an analytical standard that is used in drug development and research. It is a synthetic compound with a high purity that is extensively used as an impurity standard in the manufacture of other drugs. The CAS number for 2-demethoxy-2-chloro urapidil is 34661-73-9.

O-Desmethyl urapidil is an impurity of the drug product, urapidil. It is a synthetic compound that is not found in nature. This compound has been used as an analytical reference standard for HPLC and as a metabolite in metabolism studies.

Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels.

Applications A metabolite of Valproic Acid. References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.

Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.