Alpha blockers

Labetalol: mixed alpha/beta blocker for hypertension, oral or IV; affected by CYP2C19 genetics.

(S)-Terazosin is an active S-enantiomer of Terazosin.

Applications Mirtazapine (M365000) impurity. References Reddy, T. et al.; J. Liq. Chromatogr. R. T. 31, 1204 (2008)

Applications The main metabolite of Mirtazapine (M365000). References Delbressine, L., et al.: Clin. Drug Invest., 15, 45 (1998), Anderson, D., et al.: J. Anal. Toxicol., 23, 544 (1999), Paus, E., et al.: Ther. Drug Monit., 26, 366 (2004),

Alfuzosin is a potent, selective, and long-acting α1A-adrenergic receptor antagonist. It is used to treat benign prostatic hyperplasia (BPH) in males. Alfuzosin is also used as an antihypertensive agent, for the treatment of pheochromocytoma, and for the treatment of benign prostatic hyperplasia in males. The hydrogenation of 2,3,4,5-tetradehydroalfuzosin to alfuzosin hydrochloride is performed by liquid hydrogenation or by hydrogenation on a palladium catalyst in a mixture of dimethylformamide and hexamethylphosphoramide. This process minimizes the formation of impurities such as 2,3,4-trimethoxy alfuzosin.

(R)-Carvedilol is a non-selective blocker of β/α-1. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof