Beta Blockers

Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability. References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)

Ether-alcohols and their halogenated, sulfonated, nitrated or nitrosated derivatives not elsewhere specified or included

Applications Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);

Stability Hygroscopic Applications Atorvastatin-d5 Sodium Salt, is the labeled analogue of Atorvastatin (A791750). Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

Impurity Amiodarone EP Impurity F / Amiodarone USP Related Compound F Applications De(diethylaminoethyl-5-iodo) Amiodarone (Amiodarone EP Impurity F) is an intermediate of Amiodarone (A632950), a non-selective ion channel blocker and an antiarrhythmic (class III). References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997),

Applications Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. References Klutchko, S., et al.: J. Med. Chem., 29, 1953 (1986), Holt, P., et al.: Eur. J. Clin. Pharmacol., 31, 9 (1986),

Cardiovascular drugs, nesoi

Applications A labelled metabolite of Spironolactone. References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Stability Very Hygroscopic Applications Labelled (R,R)-Labetalol (L096500). (R,R)-Labetalol is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol is used as an antihypertensive. References Sybertz, E.J., et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981), Clifton, J.E., et al.: J. Med. Chem., 25, 670 (1982), Goa, K.L., et al.: Drugs, 37, 583 (1989),

Impurity Fluocinolone Acetonide EP Impurity E Stability Hygroscopic Applications (6α,9β,11β,16α)-9,11-Epoxy-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, can be used in the production of fluocinolone acetonide (F455800). References Grinenko, G.S, Khimiko-Farmatsevticheskii Zhurnal, 12, 110 (1978), Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications A β1 selective aryloxypropanolamine andrenergic antagonist which is used in the treatment of a variety of cardiovascular disorder (1,2).Antihypertensive; antianginal; antiarrhythmic (class II). References 1. Johansson, B. et al.: Eur J Pharmacol. 1973 Nov;24(2):194-204.2. Benfield, P. et al.: Drugs. 1986 May;31(5):376-429.

Applications A metabolite of Propranolol. References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

Applications A deuterated metabolite of the drug Clopidogrel.A representative lot was: 2.5% d3, no d0 was detected.

Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive. References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)