Beta Blockers

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity.

Stability Hygroscopic Applications Pancratistatin acts as an anti-cancer compound that initiates cell-death in cancer cells. References McLachlan, A. et al.: Apoptosis, 10, 619 (2005);

Applications Isotope labelled Flocoumafen is a second generation anticoagulant rodenticide. Flocoumafen is extremely effective against strains of pest rodents resistant to conventional anticoagulants. Flocoumafen is highly toxic and is used strictly in sewers and indoors in some places such as UK. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bowler, D.J. et al.: Br. Crop Prot. Conf. Pests Dis. Proc., 2, 397 (1984); Rowe, F.P. et al.: J. Hygiene, 95, 623 (1985); Vandenbroucke, V. et al.: J. Vet. Pharmacol. Therap., 31, 437 (2008);

Stability Hygroscopic Applications a β2-adrenergic agonist, used as a bronchodilator/antiasthmatic Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Murali, S., et al.; Eur. J. Med. Chem., 42, 966 (2007), Nielen, M., et al.: Anal. Bioanal. Chem. 391, 199 (2008), Shao, B., et al.: Food Chem., 114, 1115 (2009),

Applications Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive. References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990); McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997); Pitt, B., et al.: Lancet, 355, 1582 (2000)

Ether-phenols, ether-alcohol-phenols and their halogenated, sulfonated, nitrated or nitrosated derivatives

4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride is a drug product. It is used as an analytical standard and in the development of drugs. The metabolite of 4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride, 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N-(4-nitrophenyl)benzamide, has been shown to inhibit the production of cytokines IL6 and TNFα by human monocytes, macrophages, and dendritic cells. Metabolism studies have shown that 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N

Applications A labelled (S)-enantiomer of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer. References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995);

Stability Hygroscopic Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),