GABA Modulators
GABA modulators are compounds that influence the function of GABA (gamma-aminobutyric acid) receptors, the primary inhibitory neurotransmitter receptors in the central nervous system. These modulators can either enhance or inhibit GABAergic activity, affecting neuronal excitability and synaptic transmission. GABA modulators are crucial in the treatment and study of various neurological and psychiatric disorders, including anxiety, epilepsy, and insomnia. At CymitQuimica, we offer a wide range of GABA modulators to support your research in neuroscience, pharmacology, and neurotherapeutics.
Products of "GABA Modulators"
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Phenazepam-d5
CAS:Controlled ProductApplications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),Formula:C152H4H6BrClN2OColor and Shape:NeatMolecular weight:353.63N-Demethyl Olanzapine-d8
CAS:Controlled ProductApplications A labelled metabolite of Olanzapine.Formula:C162H8H10N4SColor and Shape:NeatMolecular weight:306.46Delorazepam (100 ug/mL in Methanol)
CAS:Controlled ProductFormula:C15H10Cl2N2OColor and Shape:Single SolutionMolecular weight:305.168-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid
CAS:Formula:C13H10FN3O3Purity:99%Color and Shape:SolidMolecular weight:275.23524-Boc-7-Bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:327.221984863281251H-1,4-Benzodiazepine-2,5-dione, 3,4-dihydro-
CAS:Formula:C9H8N2O2Purity:97%Color and Shape:SolidMolecular weight:176.17202N-Desmethyl Clozapine-d8
CAS:Controlled ProductApplications A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist. References Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993), Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993), Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)Formula:C172H8H9ClN4Color and Shape:Light YellowMolecular weight:320.85(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate
CAS:Purity:97.0%Molecular weight:402.24798583984375Zopiclone N-Oxide
CAS:Impurity Zopiclone EP Impurity A Applications Eszopiclone impurity A. References Vire, J.C., et al.: Talanta, 40, 313 (1993), Sha, Yu., et al.: Molecules, 13, 1817 (2008),Formula:C17H17ClN6O4Color and Shape:White To Light BrownMolecular weight:404.812-Propylglutaric Acid
CAS:Controlled ProductApplications A metabolite of Valproic Acid. References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)Formula:C8H14O4Color and Shape:NeatMolecular weight:174.192-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]-, (1Z)-
CAS:Formula:C17H20N4OSPurity:97%Color and Shape:SolidMolecular weight:328.43199-Amino-1,2,3,4-tetrahydro-1,4-benzodiazepin-5-one
CAS:Formula:C9H11N3OPurity:95%Color and Shape:SolidMolecular weight:177.20311-Methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:190.201995849609383-Hydroxy Bromazepam 1.0 mg/mL in Methanol
CAS:Controlled ProductFormula:C14H10BrN3O2Color and Shape:ColourlessMolecular weight:332.15Flumazenil (Ro 15-1788)
CAS:Formula:C15H14FN3O3Purity:95%Color and Shape:SolidMolecular weight:303.28836319999994Ref: IN-DA005JF1
1g300.00€5gTo inquire25gTo inquire50gTo inquire5mg44.00€10mg54.00€100mg82.00€250mg139.00€Allobarbital
CAS:Controlled ProductApplications Allobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance. References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);Formula:C10H12N2O3Color and Shape:WhiteMolecular weight:208.214-Methyl-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine
CAS:Purity:95%Molecular weight:162.235992431640621'-Hydroxy Triazolam (1.0 mg/mL in DMSO)
CAS:Controlled ProductFormula:C17H12Cl2N4OColor and Shape:Single SolutionMolecular weight:359.215H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-
CAS:Formula:C10H10ClNOPurity:97%Color and Shape:SolidMolecular weight:195.6455Zaleplon-D5
CAS:Controlled ProductApplications Selective non-benzodiazepine GABAA receptor agonist. References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)Formula:C172H5H10N5OColor and Shape:Off White SolidMolecular weight:310.36Chlordiazepoxide-d5
CAS:Controlled ProductApplications Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics. References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978),Formula:C162H5H9ClN3OColor and Shape:NeatMolecular weight:304.797-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:95.0%Molecular weight:252.31700134277344Talbutal
CAS:Controlled ProductApplications A stuctural isomer of Butalbital (B690100). A short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). Sedative, hypnotic. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nielsen, C.J. et al.: Pharmacol., 26, 371 (1925); Lien, E.J. et al.: Acta Pharmac. Jug., 34, 123 (1984);Formula:C11H16N2O3Color and Shape:NeatMolecular weight:224.26(4RS)-4-(2-Methylpropyl)pyrrolidin-2-one (4-Isobutylpyrrolidin-2-one; (RS)-Pregabalin Lactam)
CAS:Color and Shape:Neat4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
CAS:Purity:95.0%Molecular weight:190.201995849609388-Amino-4-Boc-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Molecular weight:263.341003417968751,3-Dimethyl Barbituric Acid
CAS:Controlled ProductApplications 1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid (B118650). All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position. References Gupta, K., et al.: Eur. J. Med. Chem., 17, 448 (1982), Weber, L., et al.: Curr. Med. Chem., 9, 2085 (2002), Skiles, J., et al.: Curr. Med. Chem., 11, 2911 (2004),Formula:C6H8N2O3Color and Shape:NeatMolecular weight:156.14Ref: IN-DA00EB3S
Discontinued productClobazam-d5
CAS:Controlled ProductApplications Labelled Clobazam (C582500). Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant). References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),Formula:C16H8D5ClN2O2Color and Shape:Off White PowderMolecular weight:305.77nor-Flurazepam
CAS:Controlled ProductImpurity Flurazepam USP Related Compound F Applications The major human metabolite of Flurazepam. Controlled substance.Flurazepam USP Related Compound F. References Ochs, H.R., et al.: Pharmacology, 36, 166 (1988); Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990);Formula:C15H10ClFN2OColor and Shape:White To Off-WhiteMolecular weight:288.705-Allyl-6-imino-5-(1-methyl-2-pentynyl)hydrouracil-13C,15N2
Controlled ProductFormula:C12CH17NN2O2Color and Shape:NeatMolecular weight:250.2710-Hydroxy-10,11-dihydrocarbamazepine
CAS:Controlled ProductFormula:C15H14N2O2Color and Shape:NeatMolecular weight:254.28Rufinamide USP Related Compound B
CAS:Controlled ProductFormula:C11H9F2N3O2Color and Shape:NeatMolecular weight:253.20Secobarbital
CAS:Controlled ProductApplications Barbiturates are being widely used as antiepileptics, hypnotics, and anesthetics.Controlled substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Inaba, T., et al.: Clin. Pharm. Ther., 20, 439 (1976), Sun, S., et al.: J. Pharm. Sci., 66, 477 (1977), Coudore, F., et al.: J .Anal. Toxicol., 17, 109 (1993), Ferslew, K., et al.: J. Forensic Sci., 40, 245 (1995),Formula:C12H18N2O3Color and Shape:WhiteMolecular weight:238.282,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:Solid, White to yellow/orange crystalline powderMolecular weight:148.20899963378906Diazepam-13C,d3
CAS:Controlled ProductApplications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972), Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978), Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990), Murray, J.B., et al.: J. Psychol., 124, 655 (1990), Pellock, J.M., et al.: Drug Saf., 27, 383 (2004),Formula:C1513CH10D3ClN2OColor and Shape:NeatMolecular weight:288.7510H-Thieno[2,3-b][1,5]benzodiazepin-4-amine, 2-methyl-,monohydrochloride
CAS:Formula:C12H12ClN3SPurity:95%Color and Shape:SolidMolecular weight:265.7618Pinazepam
CAS:Controlled ProductApplications Pinazepam is a is a benzodiazepine. Pinazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Pinazepam is less toxic than Diazepam. This is a contolled substance (depressant). Anxiolytic. References Bertoncelli, V., et al.: Clin. Ter., 94, 641 (1980); Miyaguchi, H., et al.: Forensic Sci. Int., 157, 57 (2006), ElSohly, M., et al.: J. Anal. Toxicol., 32, 547 (2008), Vogliardi, S., et al.: Anal. Bioanal. Chem., 2011, 400, 51 (2011),Formula:C18H13ClN2OColor and Shape:NeatMolecular weight:308.76Zolazepam Hydrochloride
CAS:Controlled ProductApplications A sedative and anesthetic agent. References Winters, W., et al.: Neuropharmacology, 11, 303 (1972), Genevois, J., et al.: Rec. Med. Vet.,164, 289 (1988),Formula:C15H15FN4O·ClHColor and Shape:NeatMolecular weight:322.77Clozapine
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H19ClN4Color and Shape:Crystalline powder, YellowMolecular weight:326.83
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