GABA Modulators
GABA modulators are compounds that influence the function of GABA (gamma-aminobutyric acid) receptors, the primary inhibitory neurotransmitter receptors in the central nervous system. These modulators can either enhance or inhibit GABAergic activity, affecting neuronal excitability and synaptic transmission. GABA modulators are crucial in the treatment and study of various neurological and psychiatric disorders, including anxiety, epilepsy, and insomnia. At CymitQuimica, we offer a wide range of GABA modulators to support your research in neuroscience, pharmacology, and neurotherapeutics.
Products of "GABA Modulators"
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Triazolam-d3
CAS:Controlled ProductApplications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia. References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).Formula:C17H9D3Cl2N4Color and Shape:NeatMolecular weight:346.232,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE
CAS:Formula:C9H12N2Purity:97%Color and Shape:SolidMolecular weight:148.205N-Desmethyl Clobazam-d5
CAS:Controlled ProductApplications The major labelled metabolite of Clobazam (C582500). Controlled substance (depressant). References Bardy, A., et al.: Brain Develop., 13, 174 (1991), Patsalos, P., et al.: Epilepsia, 43, 365 (2002), Venisse, N., et al.: J. Anal. Toxicol., 27, 7 (2003),Formula:C152H5H6ClN2O2Color and Shape:Off-WhiteMolecular weight:291.74Nimetazepam (1mg/ml in Methanol)
CAS:Controlled ProductFormula:C16H13N3O3Color and Shape:Single SolutionMolecular weight:295.29Pentobarbital Sodium Salt (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C11H17N2O3·NaColor and Shape:Single SolutionMolecular weight:248.253-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS:Purity:95.0%Molecular weight:251.28900146484375Phenobarbital-d5 (100μg/mL in Methanol)
CAS:Controlled ProductFormula:C122H5H7N2O3Color and Shape:Single SolutionMolecular weight:237.27[2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone
CAS:Impurity Clozapine EP Impurity D Applications [2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone (Clozapine EP Impurity D) is used in the synthesis of substituted dibenzodiazepines. Also an impurity in the synthesis of Clozepine (C587500), an antipsychotic. References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)Formula:C18H21ClN4OColor and Shape:Light Red To RedMolecular weight:344.84(S)-Viloxazine Hydrochloride
CAS:Controlled ProductApplications The (S)-isomer of Viloxazine (V312440). Antidepressant. References Howe, R., et al.: J. Med. Chem., 19, 1074 (1976), Pinder, R.M., et al.: Drugs, 13, 401 (1977),Formula:C13H20ClNO3Color and Shape:NeatMolecular weight:273.763-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one
CAS:Formula:C15H10ClN3O3Color and Shape:NeatMolecular weight:315.71Barbital-d5
CAS:Controlled ProductApplications Prototype of the barbiturate hypnotics. This is a controlled substance (depressant). References Michaelis, L., et al.: J. Biol. Chem., 87, 33 (1930),Formula:C82H5H7N2O3Color and Shape:WhiteMolecular weight:189.22Hexobarbital-D3
CAS:Controlled ProductApplications Hexobarbital-D3 is a labelled analogue of Hexobarbital (H295350), a barbiturate derivative that exhibits hypnotic and anasthetic effects. References Laroche, M. & Brodie, B.: J. Pharm. Exp. Ther., 130, 134 (1960); Pira, R. & Lieber, L.: J. Nutr., 105, 1544 (1975)Formula:C12D3H13N2O3Color and Shape:NeatMolecular weight:239.286Isomebumal
CAS:Controlled ProductApplications Isomebumal is an impurity of Pentobarbital (P276000), an sedative and hypnotic. References Hoogmartens, J., et al.: J. Chromatograph., 219, 431 (1981); Stuper, A.J., et al.: J. Pharma. Sci., 67, 745 (1978);Formula:C11H18N2O3Color and Shape:NeatMolecular weight:226.27Clozapine-d8
CAS:Controlled ProductApplications An antipsychotic.A representative lot was 92% d8, 8% d7. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)Formula:C18H11D8ClN4Color and Shape:Light Yellow To YellowMolecular weight:334.87Zolpidem-d6
CAS:Controlled ProductApplications Deuterated Zolpidem, a selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant). References Arbilla, S., et al.: Arch. Pharmacol., 330, 248 (1985), Cashman, J.N., et al.: Brit. J. Clin. Pharmacol., 21, 205 (1986)Formula:C192H6H15N3OColor and Shape:NeatMolecular weight:313.437-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:182.64999389648438Phenobarbital-d5
CAS:Controlled ProductApplications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),Formula:C122H5H7N2O3Color and Shape:WhiteMolecular weight:237.272-(1-Aminocyclohexyl)acetic Acid
CAS:Controlled ProductFormula:C8H15NO2Color and Shape:NeatMolecular weight:157.21Fludiazepam
CAS:Controlled ProductApplications Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. References Fang, S.Y., et al.: Drug. Alcohol. Depend., 104, 140 (2009); Esteki, M., et al.: Chem. Biol. Drug. Design., 72, 409 (2008);Formula:C16H12ClFN2OColor and Shape:White To Off-WhiteMolecular weight:302.7307(R)-3-amino-9-fluoro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Purity:97%Molecular weight:269.27899169921875Mexazolam
CAS:Controlled ProductApplications Mexazolam is a benzodiazepine derivative and have been investigated for its therapeutic value in treating anxiety. Mexazolam is known to be metabolized via the CYP3A4 pathway. References Ferreira, L., et al.: Clin. Drug. Investig., 23, 235 (2003); Ishigami, M., et al.: Drug. Metab. Dispos., 30, 904 (2002); Sheridan, R.P., et al.: J. Med. Chem., 50, 3173 (2007);Formula:C18H16Cl2N2O2Color and Shape:NeatMolecular weight:363.24Sodium Barbital
CAS:Controlled ProductFormula:C8H11N2O3·NaColor and Shape:NeatMolecular weight:206.17Alpidem
CAS:Controlled ProductApplications A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic. References Min, D., et al.: Pharmacotherapy, 12, 68 (1992), Rothwell, C., et al.: J. Toxicol. Sci., 27, 35 (2002), Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Boelsterli, U., et al.: Curr. Drug Metab., 7, 715 (2006), Rietjens, I., et al.: Chem. Res. Toxicol., 19, 977 (2006),Formula:C21H23Cl2N3OColor and Shape:NeatMolecular weight:404.337-Methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:162.23599243164062Methocarbamol-d3
CAS:Controlled ProductApplications Methocarbamol-d3is deuterium labelled methocarbamol (M225950), which is a muscle relaxant (skeletal). References Topliss, J., et al.: J. Med. Chem., 22, 1238 (1979), Walters, W., et al.: Drug Discov. Today., 3, 160 (1998), Baldi, P., et al.: Bioinformatics, 16, 412 (2000), Kouznetsov, V., et al.: J. Arch. Pharm., 337, 127 (2004),Formula:C11H12D3NO5Color and Shape:NeatMolecular weight:244.267-Acetamido Clonazepam
CAS:Controlled ProductApplications Clonazepam (C587080) metabolite. References Huang, W., et al.: J. Anal. Toxicol., 19, 333 (1995), Rittner, M., et al.: J. Anal. Toxicol., 25, 115 (2001),Formula:C17H14ClN3O2Color and Shape:NeatMolecular weight:327.76Meclonazepam
CAS:Controlled ProductApplications Meclonazepam, is a drug of a benzodiazepine class similar in structure to Clonazepam (C587080). It has sedative and anxiolytic properties. It has also shown to have anti-parasitic effects against the parasitic worm Schistosoma mansoni. References O Boyle C., et al.: Euro. J. Clinic. Pharmacol., 29 (1), 105 (1985); Ansseau, M., et al.: Psychopharmacology, 87 (2), 130 (1985);Formula:C16H12ClN3O3Color and Shape:Off White SolidMolecular weight:329.74Bromazepam (1mg/mL in Methanol)
CAS:Controlled ProductFormula:C14H10BrN3OColor and Shape:ColourlessMolecular weight:316.155-Allyl-5-methallyl-barbituric Acid
CAS:Controlled ProductFormula:C11H14N2O3Color and Shape:NeatMolecular weight:222.247-AMINO-4-BOC-4,5-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Purity:97.0%Molecular weight:277.32400512695311'-Hydroxy Triazolam
CAS:Controlled ProductApplications A metabolite of Triazolam (T767380(M)), which is a sedative; a controlled substance (depressant). References Boxenbaum, H., et al.: J. Pharm. Pharm. Sci., 2, 47 (1999), Perloff, M., et al.: J. Pharmacol. Exp. Ther., 292, 618 (2000), Patki, K., et al.: Drug Metab. Dispos., 31, 938 (2003),Formula:C17H12Cl2N4OColor and Shape:Light GreenMolecular weight:359.21Zolpidem Hemitartrate
CAS:Controlled ProductFormula:C19H21N3O·C4H6O6Color and Shape:WhiteMolecular weight:764.87Cyclobenzaprine-d3 Hydrochloride
CAS:Controlled ProductApplications Use as muscle relaxant (skeletal). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Cotton, M.L., et al.: Anal. Profiles Drug Subs., 17, 41 (1988),Formula:C202H3H18N·ClHColor and Shape:White To YellowMolecular weight:314.87Phenobarbital N-Beta-D-Glucoside
CAS:Controlled ProductApplications A metabolite of Phenobarbital (P316760). References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),Formula:C18H22N2O8Color and Shape:NeatMolecular weight:394.38Methohexital (Mixture of Diastereomers)
CAS:Controlled ProductApplications Methohexital is a short-acting barbiturate used as a sedative. Methohexital is used an anesthetic for oral surgery and dentistry and is also used to induce anesthesia prior to electroconvulsive therapy (ECT). Methohexital is a Controlled Substance. Analog of secobarbital (S235000). References Avramov, M.N. et al.: Anesth. Analges., 81, 596 (1995); Hamid, S.K. et al.: Br. J. Anaesth., 77, 727 (1996);Formula:C14H18N2O3Color and Shape:NeatMolecular weight:262.30Butalbital (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C11H16N2O3Color and Shape:ColourlessMolecular weight:224.26Nordazepam-d5 (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C152H5H6ClN2OColor and Shape:Single SolutionMolecular weight:275.74Zopiclone
CAS:Controlled ProductStability Hygroscopic Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic. References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),Formula:C17H17ClN6O3Color and Shape:White To Off-WhiteMolecular weight:388.81
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