GABA Modulators
GABA modulators are compounds that influence the function of GABA (gamma-aminobutyric acid) receptors, the primary inhibitory neurotransmitter receptors in the central nervous system. These modulators can either enhance or inhibit GABAergic activity, affecting neuronal excitability and synaptic transmission. GABA modulators are crucial in the treatment and study of various neurological and psychiatric disorders, including anxiety, epilepsy, and insomnia. At CymitQuimica, we offer a wide range of GABA modulators to support your research in neuroscience, pharmacology, and neurotherapeutics.
Products of "GABA Modulators"
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3-Hydroxy Prazepam
CAS:Controlled ProductApplications 3-Hydroxy-prazepam is a metabolite of Prazepam (P702250), a benzodiazepine commonly prescribed to treat anxiety. References Kingstone, E.,et al.: Curr. Ther. Res. Clin. E., 8, 159 (1966); Lemoine, P., et al.: Pharmacopsychiatry, No vol. given, No pp. given, (1991);Formula:C19H17ClN2O2Color and Shape:NeatMolecular weight:340.808-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one
CAS:Purity:97.0%Molecular weight:241.087997436523447-Hydroxy-furo[3,4-b]pyrazin-5-one, 70%
CAS:Controlled ProductApplications 7-Hydroxy-furo[3,4-b]pyrazin-5-one is a derivative of 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (C379925) which is an impurity of Eszopiclone (E889150), a nonbenzodiazepine hypnotic agent used as a treatment for insomnia. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Formula:C6H4N2O3Purity:70%Color and Shape:NeatMolecular weight:152.11Eszopiclone
CAS:Controlled ProductApplications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Formula:C17H17ClN6O3Color and Shape:Off WhiteMolecular weight:388.812,2-Dipropylpentanoic Acid
CAS:Controlled ProductFormula:C11H22O2Color and Shape:NeatMolecular weight:186.292-Propylpentanenitrile
CAS:Controlled ProductFormula:C8H15NColor and Shape:NeatMolecular weight:125.21Pridinol Methanesulfonate Salt
CAS:Controlled ProductApplications Used as an antiparkinsonian agent and as an anticholinergic. References Duperray, B., et al.: Eur. J. Drug Metab. Pharmacokinet., 2, 121 (1977),Formula:C20H25NO·CH4O3SColor and Shape:White To Off-WhiteMolecular weight:391.521’-Hydroxy Midazolam (100 ug/mL in methanol)
CAS:Controlled ProductFormula:C18H13ClFN3OColor and Shape:Single SolutionMolecular weight:341.77Talbutal-d5
CAS:Controlled ProductApplications A labelled stuctural isomer of Butalbital (B690100). A short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). Sedative, hypnotic. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nielsen, C.J. et al.: Pharmacol., 26, 371 (1925); Lien, E.J. et al.: Acta Pharmac. Jug., 34, 123 (1984);Formula:C11H11D5N2O3Color and Shape:NeatMolecular weight:229.294-Hydroxy Triazolam
CAS:Controlled ProductStability Light Sensitive Applications A metabolite of Triazolam (T767380). References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).Formula:C17H12Cl2N4OColor and Shape:NeatMolecular weight:359.21Barbituric Acid-13C,15N2
CAS:Controlled ProductApplications Parent compound of barbiturate drugs. References Luo, Y., et al.: J. Med. Chem., 53, 3846 (2010), Tomasic, T., et al.: Eur. J. Med. Chem., 45, 1667 (2010), Gilbert, A., et al.: Bioorg. Med. Chem. Lett., 20, 636 (2010),Formula:C313CH415N2O3Color and Shape:NeatMolecular weight:131.075H-Dibenzo[b,f]azepine (Iminostilbene)
CAS:Controlled ProductFormula:C14H11NColor and Shape:NeatMolecular weight:193.24Methylbarbital
CAS:Controlled ProductApplications Methylbarbital is a barbituate which displays anticonvulsant/antiepileptic activity. References Lien, E. et al.: J. Pharm. Sci.., 68, 463 (1979); Kesselheim, A. et al.: Drugs, 70, 605 (2010);Formula:C9H14N2O3Color and Shape:WhiteMolecular weight:198.221-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:98%Molecular weight:250.30099487304688Pentobarbital
CAS:Controlled ProductApplications Pentobarbital is a narcotic and sedative barbiturate drug formerly used to relieve insomnia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972), Woster, P.S., et al.: Clin. Pharm., 9, 762 (1990), Evans, A.T., et al.: J. Am. Vet. Med. Assoc., 203, 664 (1993),Formula:C11H18N2O3Color and Shape:NeatMolecular weight:226.27Allobarbital-d10
CAS:Controlled ProductApplications Labelled Allobarbital, a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance. References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);Formula:C10D10H2N2O3Color and Shape:White To Off-WhiteMolecular weight:218.275Clozapine N-Oxide
CAS:Controlled ProductImpurity CLOZAPINE N-OXIDE IMPURITY Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major metabolite of clozapine (C587500) that can be monitored by HPLC. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Baldessarini, E., et al.: Neuropsychopharmacol., 9, 117 (1993); Lin, G., et al.: J. Pharm. Sci, 83, 1412 (1994); Roth, B.L., et al.: J. Pharmacol. Exp. Ther., 268, 1403 (1994)Formula:C18H19ClN4OColor and Shape:Light Yellow To YellowMolecular weight:342.82Valproic Acid EP Impurity E
CAS:Controlled ProductFormula:C5H11NOColor and Shape:NeatMolecular weight:101.15Clorazepic Acid Ethyl Ester
CAS:Controlled ProductApplications Clorazepic Acid Ethyl Ester is an ethyl ester of Clorazepic Acid (C587365, Dipotassium Salt) which is an anxiolytic. References Cone, E., et al.: J. Pharm. Sci., 73, 243 (1984), Maurer, H., et al.: J. Anal. Toxicol., 25, 237 (2001), Beyer, J., et al.: Ther. Drug Monit., 27, 151 (2005)Formula:C18H15ClN2O3Color and Shape:White To Light YellowMolecular weight:342.78Flubromazepam (7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
CAS:Controlled ProductFormula:C15H10BrFN2OMidazolam-d6 (1mg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C18D6H7ClFN3Color and Shape:Single SolutionMolecular weight:331.806-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione-d5
CAS:Controlled ProductFormula:C11D5H14N3O2Color and Shape:NeatMolecular weight:230.3187-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:95.0%Molecular weight:315.1700134277344Desmethyldiazepam-D5 (Nordazepam-D5), 0.1mg/ml in Methanol
CAS:Controlled ProductFormula:C152H5H6ClN2OAlphenal
CAS:Controlled ProductApplications Barbituric Acid (B118650) derivative with anti-convulsive properties. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Carissime, M. et al.: Farmac. Edi. Sci., 17, 390 (1962); Harvey, D.J. et al.: Drug. Metab. Disp., 5, 527 (1977);Formula:C13H12N2O3Color and Shape:NeatMolecular weight:244.25Pirenzepine-d8 Dihydrochloride
CAS:Controlled ProductFormula:C19H15D8Cl2N5O2Color and Shape:NeatMolecular weight:432.37Flurazepam Dihydrochloride
CAS:Controlled ProductApplications Flurazepam Dihydrochloride is used as an sedative, hypnotic. This is a controlled substance (depressant). References Sternbach, L.H., et al.: J. Med. Chem., 8, 815 (1965); Schwartz, et al.: J. Med. Chem., 11, 770, (1968); Armagnac, et al.: Therapie, 26, 439 (1971); Ganjali, M., et al.: Curr. Pharm. Anal., 5, 28 (2009);Formula:C21H23ClFN3O·2ClHColor and Shape:Light Orange Colour To YellowMolecular weight:460.808-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:182.649993896484385-Phenyl-5-ethyl-2-thiobarbituric Acid-d5
CAS:Controlled ProductApplications Phenobarbital derivative. References Foltz, R.L., et al.: Biochem. Med., 6, 294 (1972),Formula:C122H5H7N2O2SColor and Shape:NeatMolecular weight:253.33Thiobutabarbital
CAS:Controlled ProductApplications Anesthetic. References DesJarlais, R., et al.: J. Med. Chem ., 31, 722 (1988), Woo, Y., et al.: Toxicol. Lett., 79, 219 (1995), Blundell, T., et al.: Nature, 384, 23 (1996),Formula:C10H16N2O2SColor and Shape:NeatMolecular weight:228.31(S)-5-(4-Hydroxyphenyl)-5-ethylhydantoin
CAS:Controlled ProductFormula:C11H12N2O3Color and Shape:NeatMolecular weight:220.22Phenobarbital N-beta-D-Glucuronide
CAS:Controlled ProductApplications A metabolite of Phenobarbital (P316760). References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),Formula:C18H20N2O9Color and Shape:NeatMolecular weight:408.359(2-Amino-5-nitrophenyl)(2-chlorophenyl)methanone
CAS:Controlled ProductFormula:C13H9ClN2O3Color and Shape:NeatMolecular weight:276.68Pregabalin Paraben Amide ((3S)-3-[[(4-Hydroxybenzoyl)amino]methyl]-5-methyl Hexanoic Acid)
CAS:Color and Shape:NeatCyanoguanidine-15N4
CAS:Controlled ProductStability Hygroscopic Applications Labelled Cyanoguanidine (C981350). A guanidine derivative used in the synthesis of barbiturates. References Kumar, U., et al.: Curr. Sci., 79, 224 (2000), Di, H., et al.: Biol. Fertil. Soils, 2006, 42, 472 (2006),Formula:C2H415N4Color and Shape:White To Light BeigeMolecular weight:88.0536Loprazolam
CAS:Controlled ProductApplications Sedative, hypnotic. Controlled substance (depressant). References Agar, J.R., et al.: J. Med. Chem., 20, 1035 (1977), Clark, B.G., et al.: Drugs, 31, 500 (1986),Formula:C23H21ClN6O3Color and Shape:YellowMolecular weight:464.90Pregabalin Methyl Ester Hydrochloride
CAS:Controlled ProductFormula:C9H19NO2·ClHColor and Shape:NeatMolecular weight:209.71Lormetazepam
CAS:Controlled ProductApplications An analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant). References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),Formula:C16H12Cl2N2O2Color and Shape:Light Yellow To Light GreenMolecular weight:335.18Lorazepam Acetate ((3RS)-7-Chloro-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl Acetate)
CAS:Controlled ProductFormula:C17H12Cl2N2O3ALLYL ISOPROPYL ACETYLUREA
CAS:Formula:C9H16N2O2Purity:98%Color and Shape:SolidMolecular weight:184.23554000000001
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