GABA Modulators
GABA modulators are compounds that influence the function of GABA (gamma-aminobutyric acid) receptors, the primary inhibitory neurotransmitter receptors in the central nervous system. These modulators can either enhance or inhibit GABAergic activity, affecting neuronal excitability and synaptic transmission. GABA modulators are crucial in the treatment and study of various neurological and psychiatric disorders, including anxiety, epilepsy, and insomnia. At CymitQuimica, we offer a wide range of GABA modulators to support your research in neuroscience, pharmacology, and neurotherapeutics.
Products of "GABA Modulators"
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7-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:166.19900512695312Flubromazepam
CAS:Controlled ProductApplications Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam (P295300); a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam (P295300) can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Moosmann, B., et al.: J. Mass Spectrom., 48, 1150 (2013); Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)Formula:C15H10BrFN2OColor and Shape:WhiteMolecular weight:333.164-Boc-2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:248.32600402832032,2’-(1,4-Piperazinediyl)bis-pyrimidine
CAS:Controlled ProductImpurity Buspirone EP Impurity G Applications 2,2’-(1,4-Piperazinediyl)bis-pyrimidine is an impurity of Buspirone (B689850), an non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. References Quaglia, M.G., et al.: J. Pharma. Biomed. Anal., 13, 505 (1995);Formula:C12H14N6Color and Shape:NeatMolecular weight:242.28Butalbital-d5
CAS:Controlled ProductApplications Labelled Butalbital (B690100). Controlled substance (depressant). Sedative, hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Inaba, T., et al.: Clin. Pharmacol. Ther., 18, 558 (1975), Fritch, D., et al.: J. Anal. Toxicol., 33, 569 (2009), Wille, S., et al.: Ther. Drug Monit., 31, 511 (2009),Formula:C112H5H11N2O3Color and Shape:WhiteMolecular weight:229.297-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE HCL
CAS:Purity:95.0%Molecular weight:263.55999755859375Secbutabarbital
CAS:Controlled ProductApplications Controlled substance (depressant). Sedative, hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Heller, D., et al.: J. Agric. Food Chem., 49, 4597 (2001), Ramirez, A., et al.: Anal. Chem., 79, 3155 (2007),Formula:C10H16N2O3Color and Shape:WhiteMolecular weight:212.256-Chloro-2-(chloromethyl)-4-phenyl-quinazoline
CAS:Controlled ProductApplications Chlordiazepoxide (C327050) derivative.Formula:C15H10Cl2N2OColor and Shape:NeatMolecular weight:305.1610H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-4-oxido-1-piperazinyl)-
CAS:Formula:C17H20N4OSPurity:97%Color and Shape:SolidMolecular weight:328.4319Pentanenitrile (Valeronitrile)
CAS:Controlled ProductFormula:C5H9NColor and Shape:NeatMolecular weight:83.135,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity)
CAS:Formula:C12H10N2OSPurity:96%Color and Shape:SolidMolecular weight:230.2856Ref: IN-DA00C31Z
Discontinued productMethylphenobarbital-d3
CAS:Controlled ProductApplications Controlled substance (depressant). Anticonvulsant; sedative; hypnotic. References Price, W.C., et al.: J. Pharm. Pharmacol., 6, 522 (1954), Brochman-Hanssen, E., et al.: J. Pharm. Sci., 58, 370 (1969), Lackner, H., et al.: Arch. Toxikol., 26, 220 (1970),Formula:C13H11D3N2O3Color and Shape:NeatMolecular weight:249.28Flubromazepam (7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) 1.0 mg/ml in Methanol
CAS:Controlled ProductFormula:C15H10BrFN2O5-Methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS:Controlled ProductFormula:C11H10N2O3Color and Shape:NeatMolecular weight:218.21Nitrazepam (100μg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C15H11N3O3Color and Shape:ColourlessMolecular weight:281.27Zolpidem Phenyl-4-carboxylic Acid
CAS:Applications A major metabolite of Zolpidem. References Crestani, F., et al.: Br. J. Pharmacol., 131, 1251 (2000), Li, Q., et al.: Bioorg. Med. Chem. Lett., 12, 465 (2002), Goulle, J., et al.: Ther. Drug Monit., 26, 206 (2004), Ohkanda, J., et al.: J. Med. Chem., 47, 432 (2004), Blackaby, W., et al.: Bioorg. Med. Chem. Lett., 16, 1175 (2006),Formula:C19H19N3O3Color and Shape:Off-White To Light BeigeMolecular weight:337.37(2S)-2-(5-Fluoro-2,4-dinitroanilino)propanamide
CAS:Controlled ProductFormula:C9H9FN4O5Color and Shape:NeatMolecular weight:272.192-Hydroxypropyl 4-(2-Chlorophenyl)-6-nitro-quinazoline-2-carboxylate
Formula:C18H14ClN3O5Color and Shape:Neat5-Allyl-6-imino-5-(1-methyl-2-pentynyl)hydrouracil
CAS:Controlled ProductFormula:C13H17N3O2Color and Shape:NeatMolecular weight:460.6067-Fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:194.1649932861328N-Desmethyl Clotiazepam
CAS:Controlled ProductApplications Clotiazepam (C587410) metabolite, with central nervous depressant and anxiolytic activity. References Ito, K. et al.: Biopharm. Drug. Dispos., 18, 293 (1997); Nakanishi, M. et al.: J. Med. Chem., 16, 214 (1973)Formula:C15H13ClN2OSColor and Shape:NeatMolecular weight:304.79Clotiazepam
CAS:Controlled ProductApplications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance. References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);Formula:C16H15ClN2OSColor and Shape:Off-WhiteMolecular weight:318.82Methylphenobarbital
CAS:Controlled ProductApplications Controlled substance (depressant). Anticonvulsant; sedative; hypnotic. References Price, W.C., et al.: J. Pharm. Pharmacol., 6, 522 (1954), Brochman-Hanssen, E., et al.: J. Pharm. Sci., 58, 370 (1969), Lackner, H., et al.: Arch. Toxikol., 26, 220 (1970),Formula:C13H14N2O3Color and Shape:WhiteMolecular weight:246.264-(2-Methylpropyl)piperidine-2,6-dione (3-Isobutylglutarimide)
CAS:Controlled ProductFormula:C9H15NO2Color and Shape:NeatMolecular weight:169.224-Boc-7-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:266.3160095214844N-Methyl Zonisamide
CAS:Controlled ProductApplications A methylated analog of Zonisamide (Z700000) with anticonvulsant activity. References Uno, H., et al.: J. Med. Chem., 22, 180 (1979)Formula:C9H10N2O3SColor and Shape:NeatMolecular weight:226.25Tizanidine Hydrochloride
CAS:Controlled ProductApplications An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). References Turski, L., et al.: Brain Res., 379, 367 (1986), Ono, H., et al.: Gen. Pharmacol., 17, 137 (1986), Hoogstraten, M.C., et al.: Acta Neurol. Scand., 77, 224 (1988)Formula:C9H8ClN5S·ClHColor and Shape:Light YellowMolecular weight:290.177-Bromo-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Purity:95+%Molecular weight:269.0979919433594Butobarbital-d5
CAS:Controlled ProductApplications Labelled Butobarbital, a barbiturate derivative that is used as a hypnotic agent with sedative and anticonvulsant properties. Butobarbital is a Controlled Substance. References Sitsen, J.M.A. et al.: Pharmac. Week., 109, 1 (1974); Adams, R.G.: Psychopharmacologia, 40, 185 (1974);Formula:C10H11D5N2O3Color and Shape:NeatMolecular weight:217.28N-Demethyl Olanzapine
CAS:Controlled ProductApplications A metabolite of Olanzapine.Formula:C16H18N4SColor and Shape:BrownMolecular weight:298.416-(8-Chloro-4,5-dihydro-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ylidene)-2,4-cyclohexadien-1-one
CAS:Controlled ProductFormula:C18H14ClN3OColor and Shape:NeatMolecular weight:323.78Oxcarbazepine EP Impurity F
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.00Nitrazepam (1.0 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C15H11N3O3Color and Shape:ColourlessMolecular weight:281.274-Boc-8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:266.3160095214844EMEDASTINE FUMARATE
CAS:Formula:C25H34N4O9Purity:98%Color and Shape:SolidMolecular weight:534.55885999999993-AMINO-1-METHYL-5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:265.31600952148447-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS:Purity:95.0%Molecular weight:208.192001342773442-[[(2-Amino-5-nitrophenyl)(2-chlorophenyl)methylene]amino]acetic Acid
Formula:C15H12ClN3O4Color and Shape:Neat7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:255.07099914550786-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione
CAS:Controlled ProductApplications 6-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione is an impurity of Pentobarbital (P276000), an sedative and hypnotic.Formula:C11H19N3O2Color and Shape:WhiteMolecular weight:225.298-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Molecular weight:166.199005126953124-Boc-7,8-Dimethoxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Molecular weight:308.377990722656253-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one
CAS:Formula:C15H10ClN3O3Purity:98%Color and Shape:SolidMolecular weight:315.7112Mesocarb
CAS:Controlled ProductApplications Mesocarb is a CNS stimulant that acts as a dopamine reuptake inhibitor. Mesocarb is a psychotropic drug. Mesocarb is used to counteract the sedative effects of benzodiazepine drugs. References Gainetdinov, R.R. et al.: Eur. J. Pharmacol., 340, 53 (1997); Kholodov, L.E. et al.: Khim.-Farmat. Zhur., 7, 50 (1973); Valueva, L.N. et al.: Zhur. Nevropatol. Psikh. S. S. Korsak., 82, 1212 (1982);Formula:C18H18N4O2Color and Shape:NeatMolecular weight:322.36Bromazepam-d4
CAS:Controlled ProductApplications Controlled substance (depressant). Anxiolytic. Labelled Bromazepam. References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),Formula:C142H4H6BrN3OColor and Shape:NeatMolecular weight:320.18Olanzapine (1mg/ml in Acetonitrile)
CAS:Formula:C17H20N4SColor and Shape:Single SolutionMolecular weight:312.43Flumazenil Carboxylic Acid
CAS:Applications Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine. References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)Formula:C13H10FN3O3Color and Shape:White To Off-WhiteMolecular weight:275.24Clonazepam-d4 (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C152H4H6ClN3O3Color and Shape:Single SolutionMolecular weight:319.74Ketazolam
CAS:Controlled ProductStability Unstable in Solution Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Formula:C20H17ClN2O3Color and Shape:Off White CrystallineMolecular weight:368.81Ketazolam-13C,d3
CAS:Controlled ProductApplications A labelled psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Formula:C1913CH14D3ClN2O3Color and Shape:NeatMolecular weight:372.827-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
CAS:Applications An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay. References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),Formula:C17H13ClN4Color and Shape:White To Off-WhiteMolecular weight:308.76Tilivalline
CAS:Applications Tilivalline, is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis. References Mori, Sh., et al.: Tetrahedron, 47, No.27, 5051 (1991); Nagasaka, T., et al.: Tetrahedron Lett., 14, 1871 (1989);Formula:C20H19N3O2Color and Shape:Light BrownMolecular weight:333.38Pyrrolidin-2-one (2-Pyrrolidone)
CAS:Controlled ProductFormula:C4H7NOColor and Shape:NeatMolecular weight:85.102,3,4,5-Tetrahydro-1H-1,4-benzodiazepine, 95%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C9H12N2Purity:95%Color and Shape:Yellow with orange to pale brown, Crystals or powder or crystalline powder or lumpy solidMolecular weight:148.217-Amino Clonazepam
CAS:Controlled ProductApplications The major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Formula:C15H12ClN3OColor and Shape:YellowMolecular weight:285.73Cloxazolam
CAS:Controlled ProductApplications Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Substance. References Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009); Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977); Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981);Formula:C17H14Cl2N2O2Color and Shape:NeatMolecular weight:349.21Nimetazepam-d3
CAS:Controlled ProductApplications Labelled Nimetazepam (N477800). Sedative, hypnotic. Controlled substance. References Inaba, et al.: Chem. Pharm. Bull., 19, 722 (1971), Sakai, S., et al.: Arzneim.-Forsch., 22, 534 (1972),Formula:C16H10D3N3O3Color and Shape:NeatMolecular weight:298.318-Chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS:Controlled ProductFormula:C17H12ClFN4Color and Shape:NeatMolecular weight:326.765-(2-Bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Flubromazepam Isomer)
CAS:Formula:C15H10BrFN2OPirenzepine, Dihydrochloride
CAS:Controlled ProductApplications An antiulcerative. Tricyclic gastric-acid inhibitor. References Eberlein, W., et al.: Arzneimittel-Forsch., 27, 356 (1977), Hellerr, G., et al.: Verh. Deut. Ges. Inn. Med., 84, 991 (1978), Carmine, A.A., et al.: Drugs, 30,85 (1985), El-Obeid, H.A., et al.: Anal. Profiles Drug Subs., 16, 445 (1987), Homon, C.A., et al.: Ther. Drug Monit., 9, 236 (1987),Formula:C19H21N5O2·2ClHColor and Shape:NeatMolecular weight:424.324-Amino-2-methyl-10H-thieno[2,3-b][1,5]-benzodiazapine, Hydrochloride
CAS:Controlled ProductImpurity Olanzapine Impurity 6 HCl Applications Intermediate in the preparation of Olanzapine (O253750). Olanzapine Impurity 6 HCl. References Calligaro, D., et al.: Bioorg. Med. Chem. Lett., 7, 25 (1997),Formula:C12H11N3S·ClHColor and Shape:NeatMolecular weight:265.76Sultiame 100 µg/mL in Acetonitrile
CAS:Formula:C10H14N2O4S2Color and Shape:Single SolutionMolecular weight:290.362-Bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide
CAS:Controlled ProductFormula:C15H10BrClN2O4Color and Shape:NeatMolecular weight:397.61Levetiracetam EP Impurity C
CAS:Controlled ProductFormula:C5H5NOColor and Shape:NeatMolecular weight:95.10N-Descarboxymethyl-N-carboxyethyl Lacosamide (Impurity)
CAS:Controlled ProductApplications N-Descarboxymethyl-N-carboxyethyl Lacosamide is an impurity of Lacosamide (L098500), an anticonvulsant drug that enhances sodium channel slow inactivation, and is used to treat patients with epilepsy. References Doty, P., et al.: Neurotherapeutics, 4, 145 (2007); Perucca, E., et al.: Nat. Rev. Drug Discov., 7, 973 (2008); Sake, J., et al.: CNS Drugs, 24, 1055 (2010)Formula:C14H20N2O3Color and Shape:NeatMolecular weight:264.327-Amino Nimetazepam
CAS:Controlled ProductApplications A metabolite of Nimetazepam. Controlled substance. References Nishikawa, M., et al.: Forensic Sci. Int., 66, 149 (1994), Katagi, M., et al.: J. Anal. Toxicol., 24, 354 (2000),Formula:C16H15N3OColor and Shape:NeatMolecular weight:265.31Lixivaptan
CAS:Controlled ProductApplications Drug used in the treatment and prevention of cardiovascular diseases. References Lo, R., et al.: Curr. Clin. Pharmacol., 3, 156 (2008), Ghali, J., et al.: Cardiol., 111, 147 (2008),Formula:C27H21ClFN3O2Color and Shape:NeatMolecular weight:473.93Phenobarbital
CAS:Controlled ProductApplications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),Formula:C12H12N2O3Color and Shape:White To Off-WhiteMolecular weight:232.247-Amino Clonazepam-d4
CAS:Controlled ProductApplications A labelled major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Formula:C152H4H8ClN3OColor and Shape:Yellow To Light Orange ColourMolecular weight:289.754-Hydroxy Midazolam (100 μg/mL in methanol)
CAS:Controlled ProductFormula:C18H13ClFN3OColor and Shape:Single SolutionMolecular weight:341.77Phenazepam
CAS:Controlled ProductApplications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),Formula:C15H10BrClN2OColor and Shape:Light YellowMolecular weight:349.61
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